KaydedilenlerDerginizi ekleyin

Dergiler / Erciyes Medical Journal / 2022 / Cilt: 44 - Sayı: 1

The Role of Matrix Metalloproteinase-1 (-1607 1G/2G) Gene Variation in Ischemic Stroke Development

Nevra ALKANLI
Arzu AY
Sezgin KEHAYA
Sayfa
20–25
Yayın Tarihi
2022-10-11
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

However, the MMP-1 (-1607 1G/2G) gene variation was not determined to be a genetic risk factor for the development of ischemic stroke in the population of Thrace region of Turkey.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objective: The matrix metalloproteinase (MMP) family is a potential genetic risk factor for the development of cerebrovascular disease, including ischemic stroke.
📊
Temel Bulgular & Veri:MMP-1 (-1607 1G/2G) gene variation can lead to excessive MMP-1 protein production and MMP-1 enzyme activity.
💡
Sonuç & Katkı:However, the MMP-1 (-1607 1G/2G) gene variation was not determined to be a genetic risk factor for the development of ischemic stroke in the population of Thrace region of Turkey.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: The matrix metalloproteinase (MMP) family is a potential genetic risk factor for the development of cerebrovascular disease, including ischemic stroke. MMP-1 (-1607 1G/2G) gene variation can lead to excessive MMP-1 protein production and MMP-1 enzyme activity. MMPs have an important role in the pathophysiology ischemic stroke pathophysiology and clinical outcome. Thus, the sensitivity to ischemic stroke may vary according to genetic characteristics. The objective of this study was to investigate the effect of MMP-1 (-1607 1G/2G) gene variation in the development of ischemic stroke disease in the population of Thrace, Turkey. Materials and Methods: In all, 87 ischemic stroke patients and 80 healthy controls were enrolled in the study. Polymerase chain reaction and restriction fragment length polymorphism methods were used to determine the genotype distribution of MMP-1 (-1607 1G/2G) gene variations. Results: There were more 1G/1G genotype (56.9%) and 1G/2G genotypes (55.1%) of MMP-1 (-1607 1G/2G) gene variations in the patient group than in the control group. However, no significant difference was determined between the groups in the distribution of MMP-1 (-1607 1G/2G) gene variation genotypes (p=0.127). The allele frequency of MMP-1 (-1607 1G/2G) gene variation in the ischemic stroke patient and healthy control groups was not significantly different from the Hardy-Weinberg distribution (p=0.6556 and p=0.0501, respectively). Conclusion: The 1G/1G and 1G/2G genotypes of MMP-1 (-1607 1G/2G) gene variation were observed more frequently in the ischemic stroke group compared with the healthy control group. However, the MMP-1 (-1607 1G/2G) gene variation was not determined to be a genetic risk factor for the development of ischemic stroke in the population of Thrace region of Turkey.

🔖

Bu Makaleye Atıf Yap

ALKANLI, N., AY, A., KEHAYA, S. (2022). The Role of Matrix Metalloproteinase-1 (-1607 1G/2G) Gene Variation in Ischemic Stroke Development. Erciyes Medical Journal, Cilt: 44 - Sayı: 1, 20–25. https://ajindex.com/articles/502176

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Alkanli N, Ay A, Kehaya S, Sut N. Investigation of the relationship between IL-18 (-607 C/A), IL-18 (-137 G/C) gene variations and ıschemic stroke disease development in thrace region of Turkey. Immunol Invest 2021; 50(6): 634–45
  2. Chang JJ, Stanfill A, Pourmotabbed T. The role of matrix metalloproteinase polymorphisms in ıschemic stroke. Int J Mol Sci 2016; 17(8): 1323
  3. Xie Q, Zhang X, Peng S, Sun J, Chen X, Deng Y, et al. Identification of novel biomarkers in ischemic stroke: a genome-wide integrated analysis. BMC Med Genet 2020; 21(1): 66
  4. Wang L, Deng L, Yuan R, Liu J, Li Y, Liu M. Association of matrix metalloproteinase 9 and cellular fibronectin and outcome in acute ischemic stroke: A systematic review and meta-analysis. Front Neurol 2020; 11: 523506
  5. Gao N, Guo T, Luo H, Tu G, Niu F, Yan M, et al. Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population. BMC Neurol 2019; 19(1): 67
  6. Jiang Y, Liu H, Wang Y, Shi X, Shao Y, Xu Z. Meta-analysis of matrix metalloproteinase (MMP)-9 C1562T polymorphism and susceptibility to ischemic stroke in the Chinese population. J Int Med Res 2020; 48(6): 300060520926427
  7. Niu F, Wei B, Yan M, Li J, Ouyang Y, Jin T. Matrix metalloproteinase-2 gene polymorphisms are associated with ischemic stroke in a Hainan population. Medicine (Baltimore) 2018; 97(39): e12302
  8. Tabatabaee FAG, Vasudevan R, Heidari F, Khazaei S, Etemad A, et al. Association of MMP-1, 9, 12 and TIMP-1 gene polymorphisms in Malaysian male hypertensive subjects. Biomedical Research 2018; 29(9): 1734–42
  9. Khasanova LT, Stakhovskaya LV, Koltsova EA, Shamalov NA. Genetic features of cerebral stroke. [Article in Russian]. Neurosci Behav Physi 2020; 50: 992–9
  10. Misr Misra S, Talwar P, Kumar A, Kumar P, Sagar R, Vibha D, et al. Association between matrix metalloproteinase family gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis of 29 studies. Gene 2018; 672: 180–94
  11. Gallego-Fabrega C, Cullell N, Soriano-Tárraga C, Carrera C, Torres-Aguila NP, Muiño E, et al. DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues. Oncotarget. 2020; 11(10): 905–12
  12. Lakhan SE, Kirchgessner A, Tepper D, Leonard A. Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke Front Neurol 2013; 4: 32
  13. Zhang G, Li W, Guo Y, Li D, Liu Y, Xu S. MMP gene polymorphisms, MMP-1 -1607 1G/2G, -519 A/G, and MMP-1