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Dergiler / Cumhuriyet Science Journal / 2015 / Cilt: 36 - Sayı: 2

Formaldehit Toksisitesine Karşı Yeşil Çay Özütünün Koruyucu Etkisi: Swiss Albino Farelerde Genotoksik Değerlendirme

The Protective Effect of Green Tea Extract on Formaldehyde Toxicity: Genotoxic Evaluation in Swiss Albino Mice.

Betül TAŞLI
Figen ÇİÇEK
Emine YALÇIN
Güray DEMİRTAŞ
Kültiğin ÇAVUŞOĞLU
Sayfa
63–73
Yayın Tarihi
2015-01-21
DOI
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Özet

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Abstract

In the present study, protective effect of green tea extract against genotoxic effects of formaldehyde on Swiss albino mice were investigated. For this aim, we used the frequency of micronucleus, chromosomal aberrations, abnormal metaphase number and mitotic index as indicators of toxicity. Animals were randomly divided into six groups of six animals each. Green tea extract was applied with two different doses (50 and 150 mg/kg) and formaldehyde was treated with the dosage of 200 mg/kg. All mice were sacrificed at the end of treatment period and the related tissues were isolated.Formaldehyde alone-treated mice presented higher frequencies micronucleus, chrosomal aberration and abnormal metaphases compared with the controls; moreover, the mitotic index was lower than in controls. Oral treatment with gren tea extract significantly ameliorated the indices of genotoxicity induced by formaldehyde. Both doses of Green Tea extract tested provided significant protection against formaldehyde-induced toxicity, and its strongest effect was observed at the dose level of 150 mg/kg of body weight. The results obtained from this study suggest that Green Tea is a effective protective agent against Formaldehyde induced toxicity.

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Bu Makaleye Atıf Yap

TAŞLI, B., ÇİÇEK, F., YALÇIN, E., DEMİRTAŞ, G., ÇAVUŞOĞLU, K. (2015). Formaldehit Toksisitesine Karşı Yeşil Çay Özütünün Koruyucu Etkisi: Swiss Albino Farelerde Genotoksik Değerlendirme. Cumhuriyet Science Journal, Cilt: 36 - Sayı: 2, 63–73. https://ajindex.com/articles/482950

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