Genin oral kanser için bir tedavisi var mı? Genetik diş hekimliği

Dünyada en yaygın görülen kanser türleri arasında olan oral karsinom, global olarak en sık görülen altıncı kanserdir. Oral kanser, tütün ve alkol kullanımına bağlı olarak ortaya çıkan genetik mutasyonlarla ilişkilidir. Son yıllarda oral kanser hastalarının cerrahi, radyoterapik ve kemoterapik tedavilerindeki gelişmeler hasta sağkalımında anlamlı gelişmeler yaratmamıştır. İmmunoterapi, gen terapisi ve hedeflenmiş terapideki son gelişmeler oral kanser tedavisinde umut verici sonuçlar ortaya koymaktadır. Gen terapisi çevre dokuda toksik etkiler oluşturmadan hedef hücrelere spesifik genetik materyalin sunulmasını içerir. Günümüzde gen terapisi çalışmalarının çoğu kanser ve genetik bozukluklarla ilişkili kalıtsal hastalıkları hedeflemiştir. Bu derleme oral kanser türlerinde gen terapisi ile yapılmış çalışmaların temel kavram ve çeşitlerine açıklık getirmektedir. Gen terapisi oral kanser tedavisinde öne çıkan yeni çalışma alanlarından biridir.

Abstract

Worldwide, oral carcinoma is one of the most prevalent cancers and it is the sixth most common cancer globally. Oral cancer is associated with genetic mutations which occur due to the exposure to tobacco, alcohol, betel quid. Advances over recent decades in the surgical, radiotherapeutic and chemotherapeutic treatment of oral cancer patients did not produced a significant improvement in patient survival. Recent advances like immunotherapy, gene therapy, and targeted therapy are showing promising results in the management of oral cancer. Gene therapy essentially consists of introducing specific genetic material into target cells without producing toxic effects on surrounding tissue. Today, most of the gene therapy studies are aimed at cancer and hereditary diseases which are linked to genetic defects. This article highlights the basic concept, types and various studies done on oral cancer using gene therapy. Gene therapy has becoming one of the emerging fields in the management of oral cancer.

Anahtar kelimeler

Gen terapisi oral kanser Gene therapy oral cancer

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Bu Makaleye Atıf Yap

LAKSHMAN, A. R., SURESH, D. R., SURESH, K. R., LAKSHMAN, S. R., LAKSHMAN, A. R., RAO, A. G. S., RAO, A. M., HANCHATE, L. (2014). Genin oral kanser için bir tedavisi var mı? Genetik diş hekimliği. Clinical and Experimental Health Sciences, Cilt: 3 - Sayı: 4, 215–219. https://ajindex.com/articles/481840

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M. Sathish Kumar, K.M.K. Masthan, N. Aravindha Babu, Kailash Chandra Dash. Gene therapy in oral cancer: a review. JCDR 2013; 7(6): 1261-1263.
Sudbİ J, Reith A. The evolution of predictive oncology and molecularbased therapy for oral cancer prevention. Int J Cancer 2005; 115(3): 339-3 Landis SH,Murray MT, Bolden S,Wingo PA.Cancer statistics. CA Cancer J Clin 1999; 49: 8-31. Tatum EL. Molecular biology, nucleic acids and the future of medicine. Perspect Biol Med 1966; 10: 19-32.
Wigler M, Silverstein S, Lee LS, Pellicer A, Cheng Y, Axel R. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell 1977; 11: 223-232.
Anderson WF, Killos L, Sanders-Haigh L, Kretschmer PJ, Diacumakos EG. Replication and expression of thymidine kinase and human globin genes microinjected into mouse fibroblasts. Proc Nat Acad Sci USA 1980; 77: 5399-5403.
Blaese RM, Culver KW, Miller AD, Carter CS, Fleisher T, Clerici M, et al. T lymphocyte-directed gene therapy for ADA- SCID: Initial trial results after 4 years. Science 1995; 270: 475-480.
Singh A, Badni M, Singh A, Samadi FM, Kabiraj A. Gene therapy for oral cancer – journey to a new horizon. JOMFB 2012; 3(1): 203-210. Kevin J Scanlon. Cancer Gene Therapy: Challenges and Opportunities. Anticancer Research. 2004; 24: 3-7. Available from: http://www.asgt.org/history.shtml.
Lynch MA, Brightman VJ, and Greenberg MS. Burket’s oral medicine: Diagnosis and treatment. Philadelphia: Lippincott.1994 pp: 196-197. Schantz SP. Basic science advances in head and neck oncology: The past decade. Semin Surg Oncol 1995; 11: 272-279.
Heera R, Beena VT, Rency Simon, Kanaram Choudhary. Gene therapy in oral cancer: an overview. JOMFB 2010; 1(2). Patil PM, et al. Review Article on Gene Therapy. IJG 2012; 4: (1): 74-79.
Saraswathi TR, Kavitha B, Priyadarshini JV. Gene therapy for oral squamous cell carcinoma: An overview. IJDR 2007; 18(3): 120-123.
Urnov FD, Rebar EJ, Holmes MC, Zhang HS, Gregory PD. Genome editing with engineered zinc finger nucleases. Nat Rev Genet 2010; 11(9): 636-646.
Young M, Overlid N, Konopka K, Düzgünes N. Gene Therapy for Oral Cancer: Efficient Delivery of a ‘Suicide Gene’ to Murine Oral Cancer Cells in Physiological Milieu. CDA Journal 2005; 33(12): 967-971. Shillitoe EJ. Gene therapy: the end of the rainbow? Head&Neck Oncology 2009; 1(7): 1-5.
Alvarez-Erviti L, Seow Y, Yin HF et al. Delivery of siR-NA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 2011; 29(4): 341-345