KaydedilenlerDerginizi ekleyin

Dergiler / Cumhuriyet Science Journal / 2022 / Cilt: 43 - Sayı: 2

Crif1 is Required for Proper Mesenchymal to Epithelial Transition

Hani ALOTAIBI
Sayfa
165–170
Yayın Tarihi
2022-10-12
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In conclusion, Crif1 was essential for the mesenchymal to epithelial transition, and it may exert its function in cooperation with Elf3.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:The epithelial to mesenchymal and the mesenchymal to epithelial transitions (EMT and MET) are fundamental developmental processes required for shaping the embryo but are also hijacked by cancer cells during metastasis.
📊
Temel Bulgular & Veri:Recently we and others have described essential factors for the initiation and progression of MET; among them is the ETS transcription factor Elf3.
💡
Sonuç & Katkı:In conclusion, Crif1 was essential for the mesenchymal to epithelial transition, and it may exert its function in cooperation with Elf3.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

The epithelial to mesenchymal and the mesenchymal to epithelial transitions (EMT and MET) are fundamental developmental processes required for shaping the embryo but are also hijacked by cancer cells during metastasis. The regulation of EMT is very well studied, and major regulators have been identified. A similar understanding of the regulation of MET is needed. Recently we and others have described essential factors for the initiation and progression of MET; among them is the ETS transcription factor Elf3. Recent reports showed that Crif1 is critical for the function of Elf3, yet the influence on MET has not been reported. Here, we studied the involvement of Crif1 in MET using a loss of function approach in NMuMG cells. We found that the depletion of Crif1 resulted in an impaired MET. We have also noticed that Cdh1 mRNA and protein expression was not affected; instead, E-cadherin, the protein product of Cdh1, was localized to the cytoplasm. These results are in agreement with our previous findings following the depletion of Elf3. In conclusion, Crif1 was essential for the mesenchymal to epithelial transition, and it may exert its function in cooperation with Elf3.

🔖

Bu Makaleye Atıf Yap

ALOTAIBI, H. (2022). Crif1 is Required for Proper Mesenchymal to Epithelial Transition. Cumhuriyet Science Journal, Cilt: 43 - Sayı: 2, 165–170. https://ajindex.com/articles/477482

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Chen T., You Y., Jiang H., Wang Z.Z., Epithelialmesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis, J. Cell Physiol, 232(12) (2017) 3261-3272
  2. Chen J., Han Q., Pei D., EMT and MET as paradigms for cell fate switching, J. Mol. Cell Biol., 4(2) (2012) 66-69
  3. Kim D.H., Xing T., Yang Z., Dudek R., Lu Q., Chen Y.H., Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview, J. Clin. Med., 7(1) (2017)
  4. Banyard J., Bielenberg D.R., The role of EMT and MET in cancer dissemination, Connect Tissue Res., 56(5) (2015) 403-413
  5. Brabletz T., Kalluri R., Nieto M.A., Weinberg R.A., EMT in cancer, Nat Rev Cancer, 18(2) (2018) 128-134
  6. Chaffer C.L., San Juan B.P., Lim E., Weinberg R.A., EMT, cell plasticity and metastasis, Cancer Metastasis Rev., 35(4) (2016) 645-654
  7. Kalluri R., EMT: when epithelial cells decide to become mesenchymal-like cells, J. Clin. Invest, 119(6) (2009) 1417- 1419
  8. Sayan A.E., Tumour-promoting role of EMT-inducing transcription factor ZEB1 in mantle cell lymphoma, Cell Death Differ, 21(2) (2014) 194-195
  9. Wheelock M.J., Shintani Y., Maeda M., Fukumoto Y., Johnson K.R., Cadherin switching, J. Cell. Sci., 121 (Pt 6) (2008) 727-735
  10. Alotaibi H., Basilicata M.F., Shehwana H., Kosowan T., Schreck I., Braeutigam C., Konu O., Brabletz T., Stemmler M.P., Enhancer cooperativity as a novel mechanism underlying the transcriptional regulation of E-cadherin during mesenchymal to epithelial transition, Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1849(6) (2015) 731-742
  11. Li Q., Hutchins A.P., Chen Y., Li S., Shan Y., Liao B., Zheng D., Shi X., Li Y., Chan W.Y., Pan G., Wei S., Shu X., Pei D., A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes, Nat. Commun., 8 (2017) 15166
  12. Li R., Liang J., Ni S., Zhou T., Qing X., Li H., He W., Chen J., Li F., Zhuang Q., Qin B., Xu J., Li W., Yang J., Gan Y., Qin D., Feng S., Song H., Yang D., Zhang B., Zeng L., Lai L., Esteban M.A., Pei D., A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts, Cell Stem Cell, 7(1) (2010) 51-63
  13. Werth M., Walentin K., Aue A., Schonheit J., Wuebken A., Pode-Shakked N., Vilianovitch L., Erdmann B., Dekel B., Bader M., Barasch J., Rosenbauer F., Luft F.C., Schmidt-Ott K.M., The transcription factor gr