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Dergiler / Clinical and Experimental Health Sciences / 2019 / Cilt: 9 - Sayı: 1

The Comparison of Effects of Applications of Compound 48/80 and Mast Cell Mediator Suspension on Inflammation in Rats: A Methodological Study for Acute Inflammatory Pain

Erkan Kılınç
Ayhan Çetinkaya
Yaşar Dağıstan
Fatma Töre
Sayfa
34–41
Yayın Tarihi
2022-10-11
DOI
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Data were analyzed using one-way ANOVA followed by Dunnett’s post hoc test.Results: Compound-48/80 increased plasma substance-P levels (p

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Amaç & Hipotez:Objective: Inflammation underlies the pathological basis of most diseases.
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Temel Bulgular & Veri:We aimed to compare effects of administrations of the compound-48/80and mast cell mediator suspension (MCMS) obtained from peritoneal MCs on the inflammation in rats.Methods: Rats were divided into five groups (n=6): Intraperitoneally, Control group received 0.2 ml saline; C-48/80 group received 2 mg/kgcompound-48/80; MCMS group received 0.2 ml MCMS; Cr+C-48/80 group received 10 mg/kg cromolyn plus compound-48/80; Cr+MCMS groupreceived cromolyn plus MCMS.
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Sonuç & Katkı:Data were analyzed using one-way ANOVA followed by Dunnett’s post hoc test.Results: Compound-48/80 increased plasma substance-P levels (p
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: Inflammation underlies the pathological basis of most diseases. Substance-P is a key mediator that participates in various inflammatoryprocesses and painful conditions. Mast cells (MCs) have a key role in inflammatory processes via mediators released from their granules. Theexperimental models for the investigation of pathogenesis and treatment of inflammatory diseases represent merely certain characteristics ofinflammatory cases, therefore, more comprehensive models are required. We aimed to compare effects of administrations of the compound-48/80and mast cell mediator suspension (MCMS) obtained from peritoneal MCs on the inflammation in rats.Methods: Rats were divided into five groups (n=6): Intraperitoneally, Control group received 0.2 ml saline; C-48/80 group received 2 mg/kgcompound-48/80; MCMS group received 0.2 ml MCMS; Cr+C-48/80 group received 10 mg/kg cromolyn plus compound-48/80; Cr+MCMS groupreceived cromolyn plus MCMS. Potent inflammatory markers, plasma substance-P levels, and number and degranulation of dural MCs weremeasured. Data were analyzed using one-way ANOVA followed by Dunnett’s post hoc test.Results: Compound-48/80 increased plasma substance-P levels (p

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Bu Makaleye Atıf Yap

Kılınç, E., Çetinkaya, A., Dağıstan, Y., Töre, F. (2022). The Comparison of Effects of Applications of Compound 48/80 and Mast Cell Mediator Suspension on Inflammation in Rats: A Methodological Study for Acute Inflammatory Pain. Clinical and Experimental Health Sciences, Cilt: 9 - Sayı: 1, 34–41. https://ajindex.com/articles/474330

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Kaynakça (14)

  1. Schlereth T, Birklein F. Mast cells: source of inflammation in complex regional pain syndrome? Anesthesiol. 2012; 116:756-7
  2. Theoharides TC, Alysandratos KD, Angelidou A, Delivanis DA, Sismanopoulos N, Zhang B, Asadi S, Vasiadi M, Weng Z, Miniati A, Kalogeromitros D. Mast cells and inflammation. Biochim. Biophys. Acta 2012; 1822:21-33
  3. Sismanopoulos N, Delivanis DA, Alysandratos KD, Angelidou A, Therianou A, Kalogeromitros D, Theoharides TC. Mast cells in allergic and inflammatory diseases. Curr. Pharm. Des. 2012;18:2261-2277
  4. Kilinc E, Dagistan Y, Kukner A, Yilmaz B, Agus S, Soyler G, Tore F. Salmon calcitonin ameliorates migraine pain through modulation of CGRP release and dural mast cell degranulation in rats. Clin. Exp. Pharmacol. Physiol. 2018; 45(6):536-546
  5. Kilinc E, Dagistan Y, Tore F. Mast cell degranulation mediates compound 48/80-induced meningeal vasodilatation underlying migraine pain. Clin. Exp. Health Sci. 2017; 196-201
  6. Aich A, Afrin LB, Gupta K. Mast cell-mediated mechanisms of nociception. Int. J. Mol. Sci. 2015;16:29069-29092
  7. Héron A, Dubayle D. A focus on mast cells and pain. J. Neuroimmunol. 2013;264:1-7
  8. Manchanda RK, Jaggi AS, Singh N. Ameliorative potential of sodium cromoglycate and diethyldithiocarbamic acid in restraint stress-induced behavioral alterations in rats. Pharmacol. Rep. 2011;63:54-63
  9. Finn DF, Walsh JJ. Twenty-first century mast cell stabilizers. Br. J. Pharmacol.2013;170:23-37. [10] da Silva EZ, Jamur MC, Oliver C. Mast cell function: a new vision of an old cell. J. Histochem. Cytochem. 2014;62:698-738
  10. Bozic CR, Lu B, Höpken UE, Gerard C, Gerard NP. Neurogenic amplification of immune complex inflammation. Science 1996;273:1722-5
  11. Lisowska B, Lisowski A, Siewruk K. Substance P and chronic pain in patients with chronic inflammation of connective tissue. PLoS One 2015;10:e0139206
  12. Straub RH, Cutolo M. Involvement of the hypothalamicpituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role. Arthritis Rheum. 2001;44:493-507
  13. Clay F, Morris C. British inflammation research association meeting: is there any point in developing an anti-RA drug? National Heart and Lung Institute, London, UK, 21-22 November 1996. Inflamm. Res. 1997;46:243-245
  14. Gabrielian L, Helps SC, Thornton E, Turner RJ, Leonard AV, Vink R. Substance P antagonists as a novel intervention for brain edema and raised int