Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightTA can play a useful part in the prognosis and treatment of CRC patients, but further studies are required to confirm this
📌 3 Maddede Bu Makale
Abstract
Background:Recently, accumulated research has found that the expression of telomerase activity (TA) was associated with colorectal cancer (CRC) advance-ment, whereas the TA prognostic effect in CRC patients is still controversial. Aims: To investigate relationships between TA and CRC clinicopathological parameters.Study Design: Meta-analysis study.Methods: We searched published studies in databases, such as EMBASE, the Cochrane Library, PubMed, and Ovid databases (last search updated to October 2014) by meeting specified search criteria. The quality of the included studies was usually evaluated and a meta-analysis was implemented by Stata 12.0 software. We used an odds ratio (OR) with a 95% confidence interval (CI) to evaluate relationship strengths between TA and CRC clinicopathological parameters.Results: In total, 11 studies (715 patients) were in-cluded to assess the relation between TA and metas-tasis-related parameters in CRC patients. The results indicate that a senior TA expression was connected with the existence of lymph node metastasis (180 pa-tients; OR=2.85, 95% CI=1.40-5.81, p=0.004), and tu-mor site (522 patients; OR=2.93, 95% CI=1.29-6.67, p=0.010). However, a senior TA expression was not connected with tumor size (137 patients; OR=1.57, 95% CI=0.71-3.47, p=0.267), histological differen-tiation (570 patients; OR=1.28, 95% CI=0.78-2.09, p=0.332), depth of invasion (57 patients; OR=3.76, 95% CI=0.61-23.04, p=0.152), distant metastasis (123 patients; OR=1.76, 95% CI=0.54-5.74, p=0.346), and clinical stage of the cancer (543 patients; OR=1.59, 95% CI=0.74-3.38, p=0.232).Conclusion: This meta-analysis suggests that a positive TA was correlated with lymph node metastasis progres-sion and tumor site of the CRC but did not correlate with other important clinicopathological parameters. TA can play a useful part in the prognosis and treatment of CRC patients, but further studies are required to confirm this