The epidermal growth factorreceptor mutation frequency was significantly higher in women (37.1%, n=96) than in men (9.1%, n=64) (p
📌 3 Maddede Bu Makale
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Amaç & Hipotez:Aims: Epidermal growth factor receptor mutationanalysis in non-small cell lung cancer is importantfor selecting patients who will receive treatment withtyrosine kinase inhibitors.
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Temel Bulgular & Veri:In this study, we aimed toinvestigate the prevalence of epidermal growth factorreceptor mutations and mutation patterns in the Turkishpopulation.Methods: We retrospectively reviewed molecularpathology reports of 959 cases with lung cancer analysedfor epidermal growth factor receptor mutations.
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Sonuç & Katkı:The epidermal growth factorreceptor mutation frequency was significantly higher in women (37.1%, n=96) than in men (9.1%, n=64) (p
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Abstract
Aims: Epidermal growth factor receptor mutationanalysis in non-small cell lung cancer is importantfor selecting patients who will receive treatment withtyrosine kinase inhibitors. In this study, we aimed toinvestigate the prevalence of epidermal growth factorreceptor mutations and mutation patterns in the Turkishpopulation.Methods: We retrospectively reviewed molecularpathology reports of 959 cases with lung cancer analysedfor epidermal growth factor receptor mutations. Weanalysed all four epidermal growth factor receptor exonmutations using a real-time polymerase chain reactionplatform.Results: In this study, the epidermal growth factorreceptor mutation rate in the Turkish population was16.7% (160 of 959). The epidermal growth factorreceptor mutation frequency was significantly higher in women (37.1%, n=96) than in men (9.1%, n=64) (p
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Bu Makaleye Atıf Yap
ÖNDER, S., ŞENER, E., TEZEL, G. G., AYDIN, Ç. (2022). Prevalence of Epidermal Growth Factor Receptor Mutations in Patients with Non-Small Cell Lung Cancer in Turkish Population. Balkan Medical Journal, Cilt: 34 - Sayı: 6, 567–571. https://ajindex.com/articles/461187
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011;61:69-90
Republic of Turkey, Ministry of Health. Turkey cancer statistics. http://kanser. gov.tr/Dosya/ca_istatistik/ANA_rapor_2012sooonn.pdf. Accessed 1.08.2016
Stella GM, Luisetti M, Inghilleri S, Cemmi F, Scabini R, Zorzetto M, et al. Targeting EGFR in non-small cell lung cancer: lessons, experiences, strategies. Respir Med 2012;106:173-83
Arteaga CL. Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia. Semin Oncol 2002;29:3-9
Jorissen RN, Walker F, Pouliot N, Garrett TP, Ward CW, Burgess AW. Epidermal growth factor receptor: mechanisms of activation and signalling. Exp Cell Res 2003;284:31-53
Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-500
Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004;101:13306-11
Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 2005;97:339-46
Lindeman NI, Cagle PT, Beasley MB, Chitale DA, Dacic S, Giaccone G, et al. Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. J Mol Diagn 2013;15:415-53
Marchetti A, Martella C, Felicioni L, Barassi F, Salvatore S, Chella A, et al. EGFR mutations in non-small cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment. J Clin Oncol 2005;23:857-65
Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T. Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res 2004;64:8919-23
Sambrook J, Russell DW. Purification of nucleic acids by extraction with phenol:chloroform. CSH Protoc 2006:2006