KaydedilenlerDerginizi ekleyin

Dergiler / Balkan Medical Journal / 2020 / Cilt: 37 - Sayı: 4

Metformin Attenuates Ischemia-reperfusion Injury of Fatty Liver in Rats Through Inhibition of the TLR4/NF-κB Axis

Xiaohua Lİ
Liangliang WANG
Xiaoguang YANG
Chunyan HUANG
Sayfa
196–202
Yayın Tarihi
2022-10-11
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bloodand liver samples were used to analyze the related proteins andcomponents involved in the inflammatory signaling pathway.Results: We found that metformin significantly ameliorated theischemia/reperfusion injury of the fatty liver through a reduction inalanine aminotransferase/aspartate aminotransferase concentrationsin the serum and a decrease in dead cells, as shown by the terminaldeoxynucleotidyl transferase-mediated dUTP nick-end labeling assay(p

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Background: Donor organs for liver transplantation may often havefatty liver disease, which confers a higher sensitivity to ischemia/reperfusion injury.
📊
Temel Bulgular & Veri:Evidence has suggested that metformin, the first-linemedication for diabetes, has protective effects against many disorders.However, the potential role of metformin in ischemia/reperfusioninjury in fatty liver disease remains unclear.Aims: To examine the effect of metformin treatment duringischemia/reperfusion injury in fatty liver and determine the possiblemechanisms.Study Design: Animal experimentation.Methods: Sprague-Dawley male rats were fed a high-fat diet (520kcal/100 g) for 14 weeks and then were subjected to the orthotopicautologous liver transplantation model.
💡
Sonuç & Katkı:Bloodand liver samples were used to analyze the related proteins andcomponents involved in the inflammatory signaling pathway.Results: We found that metformin significantly ameliorated theischemia/reperfusion injury of the fatty liver through a reduction inalanine aminotransferase/aspartate aminotransferase concentrationsin the serum and a decrease in dead cells, as shown by the terminaldeoxynucleotidyl transferase-mediated dUTP nick-end labeling assay(p
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Background: Donor organs for liver transplantation may often havefatty liver disease, which confers a higher sensitivity to ischemia/reperfusion injury. At present, there is no effective treatment forthe condition. Evidence has suggested that metformin, the first-linemedication for diabetes, has protective effects against many disorders.However, the potential role of metformin in ischemia/reperfusioninjury in fatty liver disease remains unclear.Aims: To examine the effect of metformin treatment duringischemia/reperfusion injury in fatty liver and determine the possiblemechanisms.Study Design: Animal experimentation.Methods: Sprague-Dawley male rats were fed a high-fat diet (520kcal/100 g) for 14 weeks and then were subjected to the orthotopicautologous liver transplantation model. Sections of liver tissue werestained with hematoxylin and eosin to visualize the damage. Bloodand liver samples were used to analyze the related proteins andcomponents involved in the inflammatory signaling pathway.Results: We found that metformin significantly ameliorated theischemia/reperfusion injury of the fatty liver through a reduction inalanine aminotransferase/aspartate aminotransferase concentrationsin the serum and a decrease in dead cells, as shown by the terminaldeoxynucleotidyl transferase-mediated dUTP nick-end labeling assay(p

🔖

Bu Makaleye Atıf Yap

Lİ, X., WANG, L., YANG, X., HUANG, C. (2022). Metformin Attenuates Ischemia-reperfusion Injury of Fatty Liver in Rats Through Inhibition of the TLR4/NF-κB Axis. Balkan Medical Journal, Cilt: 37 - Sayı: 4, 196–202. https://ajindex.com/articles/460919

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Moreau R, Jalan R, Gines P, Pavesi M, Angeli P, Cordoba J, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology 2013;144:1426-37
  2. Fitzpatrick E. Understanding susceptibility and targeting treatment in non-alcoholic fatty liver disease in children; moving the fulcrum. Proc Nutr Soc 2019;78:362-71
  3. Yang HJ, Tang LM, Zhou XJ, Qian J, Zhu J, Lu L, et al. Ankaflavin ameliorates steatotic liver ischemia-reperfusion injury in mice. Hepatobiliary Pancreat Dis Int 2015;14:619-25
  4. Ramsey HE, Da Silva CG, Longo CR, Csizmadia E, Studer P, Patel VI, et al. A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression. Liver Transpl 2009;15:1613-21
  5. Li S, Fujino M, Takahara T, Li XK. Protective role of heme oxygenase-1 in fatty liver ischemia-reperfusion injury. Med Mol Morphol 2018;52:61-72
  6. Vilatoba M, Eckstein C, Bilbao G, Smyth CA, Jenkins S, Thompson JA, et al. Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis. Surgery 2005;138:342-51
  7. Shao Z, Jiao B, Liu T, Cheng Y, Liu H, Liu Y. TAK-242 treatment ameliorates liver ischemia/reperfusion injury by inhibiting TLR4 signaling pathway in a swine model of Maastricht-category-III cardiac death. Biomed Pharmacother 2016;84:495-501
  8. Pan H, Gu L, Liu B, Li Y, Wang Y, Bai X, et al. Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma. PLoS One 2017;12:e0168900
  9. Xu P, Zhang J, Wang H, Wang G, Wang CY, Zhang J. CCR2 dependent neutrophil activation and mobilization rely on TLR4-p38 axis during liver ischemia-reperfusion injury. Am J Transl Res 2017;9:2878-90
  10. Hui W, Jinxiang Z, Heshui W, Zhuoya L, Qichang Z. Bone marrow and non-bone marrow TLR4 regulates hepatic ischemia/reperfusion injury. Biochem Biophys Res Commun 2009;389:328-32
  11. Sherif IO, Al-Shaalan NH. Vildagliptin Attenuates Hepatic Ischemia/Reperfusion Injury via the TLR4/NF-kB Signaling Pathway. Oxid Med Cell Longev 2018;2018:3509091
  12. Xie T, Li K, Gong X, Jiang R, Huang W, Chen X, et al. Paeoniflorin protects against liver ischemia/reperfusion injury in mice via inhibiting HMGB1-TLR4 signaling pathway. Phytother Res 2018;32:2247-55
  13. Shen XD, Ke B, Zhai Y, Gao F, Tsuchihashi S, Lassman CR, et al. Absence of tolllike receptor 4 (TLR4) signal