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Dergiler / Archives of Rheumatology / 2021 / Cilt: 36 - Sayı: 3

Identification of sequence polymorphisms in themitochondrial deoxyribonucleic acid displacement-loop region asrisk factors for systemic lupus erythematosus

Kuangyuan QIAO
Ruixue LAI
Xiaoyun ZHANG
Xueqing GAO
Shang LI
Ruixing ZHANG
Yixin QI
Chenxing PENG
Sayfa
375–380
Yayın Tarihi
2022-10-11
DOI
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Results: The SNP accumulation in SLE patients was significantly higher than that in the controls (p=0.027, 95% confidence interval [CI]: 0.075, 1.210).The frequencies of the major alleles of the nucleotides 73G/A (p

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Amaç & Hipotez:Objectives: This study aims to evaluate the relationship between sequence polymorphisms (SNPs) in the displacement-loop (D-loop) region ofmitochondrial deoxyribonucleic acid (mtDNA) and systemic lupus erythematosus (SLE) in Chinese female patients.
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Temel Bulgular & Veri:Patients and methods: This cross-sectional study was conducted between May 2017 and October 2017.
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Sonuç & Katkı:Results: The SNP accumulation in SLE patients was significantly higher than that in the controls (p=0.027, 95% confidence interval [CI]: 0.075, 1.210).The frequencies of the major alleles of the nucleotides 73G/A (p
🔬Tür:Araştırma Makalesi
📍Kapsam:2017 Verileri
⚙️Değişkenler:Alan Parametreleri

Abstract

Objectives: This study aims to evaluate the relationship between sequence polymorphisms (SNPs) in the displacement-loop (D-loop) region ofmitochondrial deoxyribonucleic acid (mtDNA) and systemic lupus erythematosus (SLE) in Chinese female patients. Patients and methods: This cross-sectional study was conducted between May 2017 and October 2017. The mtDNA was extracted from theperipheral blood of 97 female SLE patients (mean age 40.8 years; range, 20 to 79 years) and 108 age-matched healthy controls (mean age 48.7years; range, 22 to 78 years). The SNPs of mtDNA D-loop were verified by polymerase chain reaction amplification and sequence analysis. The allelefrequencies of D-loop region were compared by the Chi-square test between SLE and control groups. Results: The SNP accumulation in SLE patients was significantly higher than that in the controls (p=0.027, 95% confidence interval [CI]: 0.075, 1.210).The frequencies of the major alleles of the nucleotides 73G/A (p

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QIAO, K., LAI, R., ZHANG, X., GAO, X., LI, S., ZHANG, R., QI, Y., PENG, C. (2022). Identification of sequence polymorphisms in themitochondrial deoxyribonucleic acid displacement-loop region asrisk factors for systemic lupus erythematosus. Archives of Rheumatology, Cilt: 36 - Sayı: 3, 375–380. https://ajindex.com/articles/447992

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Kaynakça (14)

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