KaydedilenlerDerginizi ekleyin

Dergiler / Annals of Medical Research / 2018 / Cilt: 25 - Sayı: 4

Effects of thyroid hormone supplementation on oxidative stress after sleeve gastrectomy in rats

Ferruh Kemal İSMAN
Banu İŞBİLEN BAŞOK
Ucler KİSA
Nevin Genc KAHRAMAN
Suleyman Orman
Sayfa
743–746
Yayın Tarihi
2022-10-12
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Malondialdehyde levels increased in triiodothyronine given rats compared with the control group (p

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: Sleeve gastrectomy has been used for the surgical treatment of morbid obesity.
📊
Temel Bulgular & Veri:The aim of the present study was to determine the effects of triiodothyronine supplementation on oxidative stress parameters in anastomotic tissue level.Material and Methods: Twenty-four male Wistar albino rats were divided into control (n:12), and experimental (n:12) groups and underwent sleeve gastrectomy.
💡
Sonuç & Katkı:Malondialdehyde levels increased in triiodothyronine given rats compared with the control group (p
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: Sleeve gastrectomy has been used for the surgical treatment of morbid obesity. The aim of the present study was to determine the effects of triiodothyronine supplementation on oxidative stress parameters in anastomotic tissue level.Material and Methods: Twenty-four male Wistar albino rats were divided into control (n:12), and experimental (n:12) groups and underwent sleeve gastrectomy. Experimental group rats received a single dose of triiodothyronine (400 mg/100 g) in the operation day. Rats were sacrificed on postoperative day 7. Serum thyroid hormones were analysed. The supernatants were used to measure total oxidant status, total antioxidant status, nitric oxide and malondialdehyde levels. All tissue parameters were analysed by spectrophotometric methods. Oxidative stress index values were calculated.Results: Thyroid stimulating hormone levels in both the control and triiodothyronine group did not significantly change on the 7th postoperative day (p=0.663). Free triiodothyronine levels were significantly higher in triiodothyronine group rats than in control group rats (triiodothyronine vs control: p=0.004). Although total oxidant status levels did not altered by thyroid hormone treatment (p>0.05), total antioxidant status levels significantly decreased (p0.05). Tissue nitric oxide levels were also similar in both groups (p>0.05). Malondialdehyde levels increased in triiodothyronine given rats compared with the control group (p

🔖

Bu Makaleye Atıf Yap

İSMAN, F. K., BAŞOK, B. İ., KİSA, U., KAHRAMAN, N. G., Orman, S. (2022). Effects of thyroid hormone supplementation on oxidative stress after sleeve gastrectomy in rats. Annals of Medical Research, Cilt: 25 - Sayı: 4, 743–746. https://ajindex.com/articles/447387

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Maury E, Brichard SM. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol 2010;314:1-16. Fernández-Sánchez A, Madrigal-Santillán E, Bautista M, et al. Inflammation, oxidative stress, and obesity. Int J Mol Sci 2011;12:3117-32.
  2. Eisenberg D, Bellatorre A, Bellatorre N. Sleeve gastrectomy as a stand-alone bariatric operation for severe, morbid, and super obesity. JSLS 2013;17:63-7.
  3. Mallipedhi A, Prior SL, Barry JD, et al. Changes in inflammatory markers after sleeve gastrectomy in patients with impaired glucose homeostasis and type 2 diabetes. Surg Obes Relat Dis 2014;10:1123-8.
  4. Sies H, Cadenas E. Oxidative stress: damage to intact cells and organs. Philos Trans R Soc Lond B Biol Sci 1985;311:617-31.
  5. Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007;87:245-313.
  6. Picklo M, Claycombe KJ, Meydani M. Adipose dysfunction, interaction of reactive oxygen species, and inflammation. Adv Nutr 2012;1:734-5.
  7. Schwartz HL, Oppenheimer JH. Ontogenesis of 3,5,3’-triiodothyronine receptors in neonatal rat brain: dissociation between receptor concentration and stimulation of oxygen consumption by 3,5,3’-triiodothyronine. Endocrinology 1978;103:943-8.
  8. Horrum MA, Tobin RB, Ecklund RE. Thyroxine-induced changes in rat liver mitochondrial ubiquinone. Biochem Biophys Res Commun 1986;138:381-6.
  9. Venditti P, Puca A, Di Meo S. Effects of thyroid state on H2O2 production by rat heart mitochondria: sites of production with complex I- and complex II-linked substrates. Horm Metab Res 2003;35:55-61. Fernández V, Barrientos X, Kipreos K, Valenzuela A, et al. Superoxide radical generation, NADPH oxidase activity, and cytochrome P-450 content of rat liver microsomal fractions in an experimental hyperthyroid state: relation to lipid peroxidation. Endocrinology 1985;117:496-501.
  10. Ueta Y, Levy A, Chowdrey HS, et al. Hypothalamic nitric oxide synthase gene expression is regulated by thyroid hormones. Endocrinology 1995;136:4182-7.
  11. Bangur CS, Howland JL, Katyare SS. Thyroid hormone treatment alters phospholipid composition and membrane fluidity of rat brain mitochondria. Biochem J 1995;305:29-32.
  12. Gredilla R, López Torres M, Portero-Otín M, et al. Influence of hyper- and hypothyroidism on lipid peroxidation, unsaturation of phospholipids,glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle. Mol Cell Biochem 2001;221:41-8.
  13. Kanner J, German JB, Kin