KaydedilenlerDerginizi ekleyin

Dergiler / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 9

Decreased levels of plasma preptin in female patients with knee osteoarthritis

Murat ÇAKIR
Murat KORKMAZ
Seda Sabah OZCAN
Serhat DURUSOY
Sayfa
1805–1808
Yayın Tarihi
2022-10-12
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Blood glucose, triglyceride, High-Density Lipoprotein Cholesterol (HDL-c), Low-Density Lipoprotein Cholesterol (LDL-c), total cholesterol levels and Body Mass Indices (BMI) leukocyte, lymphocyte, neutrophil, Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP) of all participants were measured.Results: The preptin levels of the knee OA patients in plasma were significantly lower (206 ± 103 ng/L) compared to the healthy control Group (501 ± 525 ng/L) (p

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: Osteoarthritis (OA) is a common joint disease which is caused by the effects of mechanical, genetic and biochemical factors.
📊
Temel Bulgular & Veri:In this study, we investigated the relation between the level of preptin, which is known to have an effect on osteoblast proliferation and differentiation, bone metabolism, and the OA disease.Materials and Methods: A total of 40 healthy control patients and 40 women who were diagnosed with knee OA were included in the present study.
💡
Sonuç & Katkı:Blood glucose, triglyceride, High-Density Lipoprotein Cholesterol (HDL-c), Low-Density Lipoprotein Cholesterol (LDL-c), total cholesterol levels and Body Mass Indices (BMI) leukocyte, lymphocyte, neutrophil, Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP) of all participants were measured.Results: The preptin levels of the knee OA patients in plasma were significantly lower (206 ± 103 ng/L) compared to the healthy control Group (501 ± 525 ng/L) (p
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: Osteoarthritis (OA) is a common joint disease which is caused by the effects of mechanical, genetic and biochemical factors. In studies conducted in recent years, it has been shown that osteoblasts play roles in OA pathogenesis. In this study, we investigated the relation between the level of preptin, which is known to have an effect on osteoblast proliferation and differentiation, bone metabolism, and the OA disease.Materials and Methods: A total of 40 healthy control patients and 40 women who were diagnosed with knee OA were included in the present study. The plasma preptin levels of the individuals who were included in the study were measured with Enzyme-linked Immuno-Sorbent Assay (ELISA) Method. Blood glucose, triglyceride, High-Density Lipoprotein Cholesterol (HDL-c), Low-Density Lipoprotein Cholesterol (LDL-c), total cholesterol levels and Body Mass Indices (BMI) leukocyte, lymphocyte, neutrophil, Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP) of all participants were measured.Results: The preptin levels of the knee OA patients in plasma were significantly lower (206 ± 103 ng/L) compared to the healthy control Group (501 ± 525 ng/L) (p

🔖

Bu Makaleye Atıf Yap

ÇAKIR, M., KORKMAZ, M., OZCAN, S. S., DURUSOY, S. (2022). Decreased levels of plasma preptin in female patients with knee osteoarthritis. Annals of Medical Research, Cilt: 26 - Sayı: 9, 1805–1808. https://ajindex.com/articles/447385

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (14)

  1. Hedbom E, Hauselmann HJ. Molecular aspects of pathogenesis in osteoarthritis: the role of inflammation. Cell Mol Life Sci 2002;59:45-53
  2. Goldring MB. The role of the chondrocyte in osteoarthritis. Arthritis Rheum 2000;43:1916-26
  3. Min BH, Kim HJ, Lim H, et al. Effects of ageing and arthritic disease on nitric oxide production by human articular chondrocytes. Exp Mol Med 2001;33:299-302
  4. Hunter DJ. Osteoarthritis. Best Pract Res Clin Rheumatol 2011;25:801-14
  5. Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarthritis Cartilage 2007;15:981-1000
  6. Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 2008;16:137-62
  7. Hunter DJ, Lo GH. The management of osteoarthritis: an overview and call to appropriate conservative treatment. Rheum Dis Clin North Am 2008;34:689-712
  8. Kacar C, Gilgil E, Urhan S, et al. The prevalence of symptomatic knee and distal interphalangeal joint osteoarthritis in the urban population of Antalya, Turkey. Rheumatol Int 2005;25:201-4
  9. Buchanan CM, Phillips AR, Cooper GJ. Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion. Biochem J 2001;360:431-9
  10. Xiao C, Li W, Lu T, et al. Preptin Promotes Proliferation and Osteogenesis of MC3T3-E1 Cells by Upregulating beta-Catenin Expression. IUBMB Life 2019
  11. Cornish J, Callon KE, Bava U, et al. Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo. Am J Physiol Endocrinol Metab 2007;292:E117-22
  12. Li N, Zheng YB, Han J, et al. Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation. BMC Musculoskelet Disord 2013;14:49
  13. Nazari Soltan Aahmad S, Nourollahi S, Kazerouni F, et al. Investigation of the relation between bone mass density and serum preptin levels in pre- and postmenopausal women. J Bone Miner Metab 2018;36:710-5
  14. Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheu