KaydedilenlerDerginizi ekleyin

Dergiler / Annals of Medical Research / 2018 / Cilt: 25 - Sayı: 4

The effect of oral puerarin administration on wound healing in diabetic rat model

Akif TURER
Mehmet Emin ONGER
Sayfa
536–539
Yayın Tarihi
2022-10-12
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Connective tissue and new vessel volumes difference were not statistically significant between group NDC and DP.Conclusion: Orally administered puerarin enhances new vessel formation and support wound healing in diabetic rats.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: The aim of this study is to examined the effect of the oral administration of puerarin on wound healing in diabetic rat.Material and methods: Twenty-four rats were divided into three groups: Group 1 (n:8) non diabetic control (NDC), group 2 (n:8) diabetic control (DC), group 3 (n:8) diabetic puerarine (DP).
📊
Temel Bulgular & Veri:Rats Group DC and DP were injected a single dose 200 mg/kg streptozin solution for diabet model.
💡
Sonuç & Katkı:Connective tissue and new vessel volumes difference were not statistically significant between group NDC and DP.Conclusion: Orally administered puerarin enhances new vessel formation and support wound healing in diabetic rats.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: The aim of this study is to examined the effect of the oral administration of puerarin on wound healing in diabetic rat.Material and methods: Twenty-four rats were divided into three groups: Group 1 (n:8) non diabetic control (NDC), group 2 (n:8) diabetic control (DC), group 3 (n:8) diabetic puerarine (DP). Rats Group DC and DP were injected a single dose 200 mg/kg streptozin solution for diabet model. A full thickness linear incision was made in the paravertebral region of the rats and the wound edges were covered with a sterile plaster. In Group NDC and DC, rats were given saline solution for 7 days. In Group DP, rats were given 200 mg/kg puerarin with oral gavage for 7 days. All animals were euthanized at 7 days postoperative. Connective tissue volumes and new vessel formation were measured with stereological analysisResults: Stereologic analysis showed that Group NDC and DP had significantly more connective tissue volume at 7 days compared with group DC. New vessel formation volumes were also significantly lesser in group DC. Connective tissue and new vessel volumes difference were not statistically significant between group NDC and DP.Conclusion: Orally administered puerarin enhances new vessel formation and support wound healing in diabetic rats.

🔖

Bu Makaleye Atıf Yap

TURER, A., ONGER, M. E. (2022). The effect of oral puerarin administration on wound healing in diabetic rat model. Annals of Medical Research, Cilt: 25 - Sayı: 4, 536–539. https://ajindex.com/articles/447300

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Bullard KM, Cowie CC, Lessem SE, et al. Prevalence of Diagnosed Diabetes in Adults by Diabetes Type -United States, 2016. MMWR Morb Mortal Wkly Rep. 2018;67:359-61.
  2. Strain WD, Paldánius PM. Diabetes, cardiovascular disease and the microcirculation. Cardiovasc Diabetol. 2018;17:57. Andersson L, Andreasen JO. Soft tissue injuries. In: Andreasen JO, Andreasen FM, Andersson L, eds. Textbook and color atlas of traumatic injuries to the teeth, 4th edition. Oxford; Blackwell Munksgaard; 2007. p. 577-97.
  3. Mostafavinia A, Masteri Farahani R, Abdollahifar MA, et al. Evaluation of the effects of photobiomodulation on partial osteotomy in streptozotocin-induced diabetes in rats. Photomed Laser Surg. 2018;31. Heshmati J, Namazi N. Effects of black seed (Nigella sativa) on metabolic parameters in diabetes mellitus: a systematic review. Complement Ther Med. 2015;23:275-82.
  4. Majid SA, Khorasgani MR, Emami SH, et al. Study of Diabetic cutaneous wound healing in rats treated with Lactobacillus Casei and its Exopolysaccharide. International Journal of Advanced Biotechnology and Research. 2016;7:2083-92.
  5. Zhou YX, Zhang H, Peng C. Puerarin: a review of pharmacological effects. Phytother Res. 2014;28:961-75
  6. Hu W, Yang X, Zhe C, et al. Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. Pharmacol Rep. 2011;63:781-9.
  7. Zhang W, Liu CQ, Wang PW, et al. Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet. Eur J Pharmacol. 2010;649:398-402.
  8. Gundersen HJ, Jensen EB, Kiêu K, et al. The efficiency of systematic sampling in stereology--reconsidered. J Microsc. 1999;193:199-211.
  9. Kochi G, Sato S, Fukuyama T, et al. Analysis on the guided bone augmentation in the rat calvarium using a microfocus computerized tomography analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:42-8.
  10. Ritarwan K, Lelo A, Pane YS, et al. Increasing Atherosclerosis in Streptozotocin-Induced Diabetes into Four Groups of Mice. Open Access Maced J Med Sci. 2018;6:287-92.
  11. Mayyas F, Jaradat R, Alzoubi KH. Cardiac effects of fish oil in a rat model of streptozotocin-induced diabetes. Nutr Metab Cardiovasc Dis. 2018;28:592-99.
  12. Deeds MC, Anderson JM, Armstrong AS, et al. Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models. Lab Anim. 2011;45:131-40.
  13. Hasegawa H, Ozawa S, Hashimoto K, et al. Type 2 diabetes impairs implant osseointegratio