Apelin has inhibitory effect of endothelium-independent relaxation in the human internal mammary artery

These results suggest that apelin may be a physiological agent against the deterioration of vascular elasticity caused byendothelial damage especially in atherosclerotic cardiac patients and hypertensive patients.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aim: Apelin has important effects on the circulatory system and heart.

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Temel Bulgular & Veri:The main aim of this study was to investigate the effectsof apelin-13 on the contraction induced by norepinephrine (NE), and the endothelium-independent relaxation induced by sodiumnitroprusside (SNP) in human internal mammary artery (IMA) obtained from patients undergoing coronary artery bypass grafting(CABG) surgery.Material and Methods: IMA rings, obtained from patients undergoing CABG surgery, were suspended in isolated tissue bathscontaining Krebs-Henseleit solution, which were continuously gassed with 95% O2 and 5% CO2 at 37°C.Results: The IMA rings were pre-contracted with increasing concentrations of norepinephrine (NE 10-9–10-4 mol/l) and theendothelium-independent relaxation responses to sodium nitroprusside (SNP) were studied.

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Sonuç & Katkı:These results suggest that apelin may be a physiological agent against the deterioration of vascular elasticity caused byendothelial damage especially in atherosclerotic cardiac patients and hypertensive patients.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: Apelin has important effects on the circulatory system and heart. The main aim of this study was to investigate the effectsof apelin-13 on the contraction induced by norepinephrine (NE), and the endothelium-independent relaxation induced by sodiumnitroprusside (SNP) in human internal mammary artery (IMA) obtained from patients undergoing coronary artery bypass grafting(CABG) surgery.Material and Methods: IMA rings, obtained from patients undergoing CABG surgery, were suspended in isolated tissue bathscontaining Krebs-Henseleit solution, which were continuously gassed with 95% O2 and 5% CO2 at 37°C.Results: The IMA rings were pre-contracted with increasing concentrations of norepinephrine (NE 10-9–10-4 mol/l) and theendothelium-independent relaxation responses to sodium nitroprusside (SNP) were studied. Apelin-13 (10 μM) caused a dosedependentrelaxation in NE pre-contracted IMA rings. Apelin also facilitated the endothelium-independent relaxation induced bySNP.Conclusion: According to the results, apelin facilitated the endothelium-independent relaxation and inhibited the contractile activityof IMA. These results suggest that apelin may be a physiological agent against the deterioration of vascular elasticity caused byendothelial damage especially in atherosclerotic cardiac patients and hypertensive patients.

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Bu Makaleye Atıf Yap

SERHATLIOĞLU, İ., KAÇAR, E., UYSAL, A., BURMA, O., KELEŞTİMUR, H., YARDIM, A., ULKER, N. (2022). Apelin has inhibitory effect of endothelium-independent relaxation in the human internal mammary artery. Annals of Medical Research, Cilt: 26 - Sayı: 3, 443–446. https://ajindex.com/articles/447246

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Kaynakça (17)

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