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Dergiler / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 7

Is there a relationship between serum kisspeptin levels and endometrial polyps in women with premenopausal status

Mehmet Kürşat DERİCİ
Engin YILDIRIM
Emre DEMİR
Omer Yavuz SİMSEK
Sayfa
1253–1257
Yayın Tarihi
2022-10-12
DOI
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The sensitivity value was 0.684 (0.512-0.819), the specificity was 0.620 (0.471-0.750).Conclusion: The serum Kisspeptin-54 and estradiol levels were found higher in patients with endometrial polyps.

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Amaç & Hipotez:Aim: Endometrial polyps are frequently associated with abnormal uterine bleeding.
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Temel Bulgular & Veri:According to the pathology results, patients were identified as polyp group (n=38) (endometrial polyps) and controlgroup (n=50) (normal endometrial findings).
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Sonuç & Katkı:The sensitivity value was 0.684 (0.512-0.819), the specificity was 0.620 (0.471-0.750).Conclusion: The serum Kisspeptin-54 and estradiol levels were found higher in patients with endometrial polyps.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: Endometrial polyps are frequently associated with abnormal uterine bleeding. The kispeptin family is one of the peptidesthat play a role in reproductive functions and whose expression varies in various uterine pathologies. The aim of the study was todetermine the relationship between serum Kisspeptin levels and endometrial polyps in women with premenopausal status.Material and Methods: The blood was collected prior to endometrial sampling from women admitted to the hospital due to abnormaluterine bleeding. According to the pathology results, patients were identified as polyp group (n=38) (endometrial polyps) and controlgroup (n=50) (normal endometrial findings). Kisspeptin-54 levels were determined by ELISA method from serum obtained fromvenous blood.Results: There were no difference was found between the patients’ age, body mass index, gravida, para, abortus and the numberof living children were compared (p>0.05). There was no statistically significant difference between the groups in terms of folliclestimulating hormone, luteinizing hormone and thyroid stimulating hormone values (p>0.05). Plasma kisspeptin (1.84±0.93 ng/dLand 1.32±0.47 ng/dL, p= 0.008) and estradiol (90.34±13.02 pg/mL and 81.75±12.36 pg/mL, p=0.002) levels were significantly higherin the polyp group than in the control group. After the Receiver Operating Characteristic (ROC) analysis the area under the curve(AUC) was 1.26 (p= 0.08), (95% CI, 0.550-0.782). The sensitivity value was 0.684 (0.512-0.819), the specificity was 0.620 (0.471-0.750).Conclusion: The serum Kisspeptin-54 and estradiol levels were found higher in patients with endometrial polyps.

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Bu Makaleye Atıf Yap

DERİCİ, M. K., YILDIRIM, E., DEMİR, E., SİMSEK, O. Y. (2022). Is there a relationship between serum kisspeptin levels and endometrial polyps in women with premenopausal status. Annals of Medical Research, Cilt: 26 - Sayı: 7, 1253–1257. https://ajindex.com/articles/447090

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