Dergiler / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 9

The importance of intraoperative evaluation for parathyroid cancer

Sayfa
2077–2081
Yayın Tarihi
2022-10-12
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In case of suspicious findings in frozen examination and intraoperativefindings, the surgical plan may be changed and the necessity of secondary surgery can be eliminated.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: There is no examination to determine the exact diagnosis of parathyroid cancer before surgery.
📊
Temel Bulgular & Veri:The aim of this study wasto discuss our surgical experience and the intraoperative findings suggestive of cancer, in parathyroid cancers operated with thediagnosis of primary hyperparathyroidism.Material and Methods: Six patients with parathyroid cancer who were operated on between May 2012 and January 2017, in theDepartment of General Surgery, Cukurova University were included in the study.
💡
Sonuç & Katkı:In case of suspicious findings in frozen examination and intraoperativefindings, the surgical plan may be changed and the necessity of secondary surgery can be eliminated.
🔬Tür:Araştırma Makalesi
📍Kapsam:2012 Verileri
⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: There is no examination to determine the exact diagnosis of parathyroid cancer before surgery. The aim of this study wasto discuss our surgical experience and the intraoperative findings suggestive of cancer, in parathyroid cancers operated with thediagnosis of primary hyperparathyroidism.Material and Methods: Six patients with parathyroid cancer who were operated on between May 2012 and January 2017, in theDepartment of General Surgery, Cukurova University were included in the study. Age, sex, complaints of the patients, calcium andparathormone values, imaging methods for localization, intraoperative findings from surgical notes were evaluated retrospectively.Results: Of the patients, 4 were females and 2 were males. The mean age was 61.6+7.28 (50-71). While the lesion was spottedincidentally in three patients, swelling in the neck, back and hip pain, pancreatitis were other reasons for admission. The mean calciumlevels were 13.05+1.86 (10.5-15.7) mg/dL, mean parathormone values were 937.4+756.9 (370-1814) pg/ml. Ultrasonography (USG)and parathyroid scintigraphy were performed to all patients. Thyroid scintigraphy was additionally performed on one patient forhyperthyroidism and then FNAB-FNAS was performed. This patient was operated on with suspected thyroid cancer. In intraoperativeevaluation, all of the lesions were firm, adherent to the thyroid capsule and surrounding tissues. One patient had inferior laryngealnerve invasion. In frozen examination, four patients with suspected parathyroid cancer was specified. Three patients had a lobectomyand 2 patients had en bloc lesion resection with total thyroidectomy. Lesion excision was performed in one patient. After finalpathology results, re-operation was suggested, however the patient did not accept.Conclusion: The definitive diagnosis in parathyroid cancer is made by postoperative pathological examination. In cases ofprimary hyperparathyroidism, in case of intravesical invasion of the thyroid capsule and surrounding tissues during intraoperativeexamination, parathyroid cancer should be suspected. In case of suspicious findings in frozen examination and intraoperativefindings, the surgical plan may be changed and the necessity of secondary surgery can be eliminated.

🔖

Bu Makaleye Atıf Yap

TOPAL, U., UGUZ, A. H., GUNAY, I. B., SAKMAN, G., RENCUZOGULLARİ, A., DALCİ, K. (2022). The importance of intraoperative evaluation for parathyroid cancer. Annals of Medical Research, Cilt: 26 - Sayı: 9, 2077–2081. https://ajindex.com/articles/447049

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (18)

  1. Givi B, Shah JP. Parathyroid carcinoma. Clin Oncol. 2010;22:498–507
  2. Wei CH, Harari A Parathyroid carcinoma: update and guidelines for management. Curr Treat Options Oncol 2012;13:11-23. 3.- Lee PK, Jarosek SL, Virnig BA, et al. Trends in the incidence and treatment of parathyroid cancer in the United States. Cancer 2007;109:1736–41
  3. De Quervain F: Parastruma maligna aberrata. Langenbecks Arch Surg 1909;100:334-53
  4. Pellitteri PK. Surgical management of parathyroid carcinoma. Operative Techniques Otolaryngol Head Neck Surg 2016;2:145-51
  5. Raghavan D, Ahluwalia MS, Blanke CD, Brown J, Kim ES, Reaman GH, Sekeres MA. Editors. Textbook of uncommon cancer. John Wiley & Sons. 2017
  6. Arrangoiz R, Cordera F, Caba D, et al. Current Understanding and Management of Parathyroid Carcinoma. J Cancer Treatment Res 2017;5:51
  7. Salcuni AS, Cetani F, Guarnieri V, et al Parathyroid carcinoma. Best Practice Res Clin Endocrinol& Metabolism 2018;32:877-89
  8. Khan MW, Worcester EM, Straus FH, et al. Parathyroid carcinoma in secondary and tertiary hyperparathyroidism. J Am Coll Surg 2004;199:312–9
  9. Villar-del-Moral J, Jiménez-García A, Salvador-Egea P, et al. Prognostic factors and staging systems in parathyroid cancer: a multicenter cohort study. Surgery 2014;156:1132– 44
  10. Bondeson L, Grimelius L, DeLellis RA, et al. Parathyroid carcinoma and Parathyroid adenoma. In: DeLellis RA, Lloyd RV, Heitz P, et al., editors. Pathology and genetics. tumors of endocrine organs. WHO Classification of Tumours. Lyon: IARC Press; 2004. p. 124–31
  11. De Lellis RA Parathyroid carcinoma. An overview. Adv Anat Pathol 2005;12:53–61
  12. Marcocci C, Cetani F, Rubin MR, et al. Parathyroid carcinoma. J Bone Mineral Res 2008;23:1869-80
  13. Dudney WC, Bodenner D, Stack BC. Parathyroid carcinoma. Otolaryngol Clin North Am. 2010;43:441-53
  14. Shane E. Clinical review 122: parathyroid carcinoma. J Clin Endocrinol Metab. 2001;86:485–93
  15. Obara T, Fujimoto Y. Diagnosis and treatment of patients with parathyroid carcinoma: An update and review. World J Surg 1991;15:738-44
  16. Adam MA, Untch BR, Olson JA. Parathyroid carcinoma: current understanding and new insights into gene expression and intraoperative parathyroid hormone kinetics. Oncologist 2010;15:61-72
  17. Wilkins BJ, Lewis JS. Non-functional parathyroid carcinoma: a review of the literature and report of a case requiring extensive surgery. Head Neck Pathol 2009;3;140-9
  18. Ardalan, M. Parathyroid carcinoma; an updated