Dergiler / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 10

High neutrophil to lymphocyte ratio and low mean platelet volume level in autism spectrum disorders

Sayfa
2382–2385
Yayın Tarihi
2022-10-12
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In the ASD group, the neutrophil/lymphocyte ratio (NLR) was significantly higher than in the control group (p

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: A growing number of studies have indicated that ASD is associated with neuro-inflammation.
📊
Temel Bulgular & Veri:In this study, we evaluated complete blood count (CBC) data in children withASD, aiming to explore associations between ASD and inflammationMaterial and Methods: Patients diagnosed with ASD between 01.01.2018 and 31.08.2019 were included in the study.
💡
Sonuç & Katkı:In the ASD group, the neutrophil/lymphocyte ratio (NLR) was significantly higher than in the control group (p
🔬Tür:Araştırma Makalesi
📍Kapsam:2018 Verileri
⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: A growing number of studies have indicated that ASD is associated with neuro-inflammation. Recent research has indicatedthat complete blood count (CBC) may be used for assessing inflammatory markers, offering a cheap, simple and reproduciblealternative that is also suitable for routine application. In this study, we evaluated complete blood count (CBC) data in children withASD, aiming to explore associations between ASD and inflammationMaterial and Methods: Patients diagnosed with ASD between 01.01.2018 and 31.08.2019 were included in the study. CBC resultsof patients from their initial visit to the clinic were analyzed. The control group consisted of children with matching age and gendervisiting the clinic for general examination. CBC parameters of both the study and control groups were evaluated statistically.Results: 67 children diagnosed with ASD and 67 healthy children were included in the study. In the ASD group, the neutrophil/lymphocyte ratio (NLR) was significantly higher than in the control group (p

🔖

Bu Makaleye Atıf Yap

KULAKSIZOĞLU, S., KOPARAN, C. (2022). High neutrophil to lymphocyte ratio and low mean platelet volume level in autism spectrum disorders. Annals of Medical Research, Cilt: 26 - Sayı: 10, 2382–2385. https://ajindex.com/articles/446797

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (15)

  1. Xu G, Strathearn L, Liu B, et al. Prevalence of autism spectrum disorder among US children and adolescents 2014-2016. Jama 2018;319:81-2
  2. Depino AM. Peripheral and central inflammation in autism spectrum disorders. Mol Cell Neurosci 2013;53: 69-76
  3. Ratajczak HV. Theoretical aspects of autism: Biomarkers A review. J Immunotoxicol 2011;8:80-94
  4. Bjorklund G, Saad K, Chirumbolo S, et al. Immune dysfunction and neuroinflammation in autism spectrum disorder. Acta Neurobiol Exp (Wars) 2016;76:257-68
  5. El-Ansary A, Al-Ayadhi L. Neuroinflammation in autism spectrum disorders. J Neuroinflammation 2012;9:265
  6. Zahorec R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratislavske lekarske listy 2001;102:5-14
  7. Ornoy A, Liza WF, Ergaz Z. Genetic syndromes, maternal diseases and antenatal factors associated with autism spectrum disorders (ASD). Front Neurosci 2016;6:316
  8. Onore C, Careaga M, Ashwood P. The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun 2012;26:383–92
  9. Loomes R, Hull L, Mandy WPL. What is the male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry 2017;56:466–74
  10. Madore C, Leyrolle Q, Lacabanne C, et al. Neuroinflammation in autism: Plausible role of maternal inflammation, dietary omega 3, and microbiota. Neural Plasticity 2016 11. Ashwood P, Krakowiak P, Hertz-Picciotto I, et al. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun 2011;25:40–5
  11. Tural Hesapcioglu S, Kasak M, Cıtak Kurt AN. High monocyte level and low lymphocyte to monocyte ratio in autism spectrum disorders. Int J Development Disabilities 2019;65:73-81
  12. Sweeten TL, Posey DJ, Mc Dougle CJ. High blood monocyte counts and neopterin levels in children with autistic disorder. Am J Psychiatr 2003;160:1691–3
  13. Kutlu A, Cevher Binici N. Does increased neutrophillymphocyte ratio predict autism spectrum disorder?. Anatolian J Psychiatr 2018;19:6
  14. Şahin N. Evaluation of neutrophil/lymphocyte ratio in children with autism and relationship between autism severities. Klinik Psikofarmakoloji Bulteni 2018;28:23-23
  15. Bjørklund G, Saad K, Chirumbolo S. et al. Geier MR. and Urbina MA. Immune dysfunction and neuroinflammation in autism spectrum disorder. Acta Neurobiol Exp (Wars