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Dergiler / Annals of Medical Research / 2020 / Cilt: 27 - Sayı: 8

An investigation of the use of SCUBE1 protein as an early prognostic marker in predicting prognosis after cardiopulmonary resuscitation in cardiac arrest patients

Ahmet MENTEŞE
Ali AYGÜN
Gürkan ALTUNTAŞ
Faruk ÖZŞAHİN
Özgür TATLI
Süleyman TÜREDİ
Selim DEMİR
Ahmet Ali TOP
Şenol ARDIÇ
Betül ABANOZ
Sayfa
2118–2123
Yayın Tarihi
2022-10-12
DOI
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However, comparison of the patient groups with good andpoor neurological prognosis in terms of SCUBE1 levels at the start of CPR revealed that SCUBE1 levels were twice as high in the poorneurological prognosis group as in the good neurological prognosis group, although the difference was not statistically significant.Conclusion: SCUBE1 levels measured at the start of CPR are not sufficient for predicting post-CPR survival and good neurologicaloutcome.

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Amaç & Hipotez:Aim: To evaluate the usefulness of Signal Peptide-CUB-EGF Domain-Containing Protein-1 (SCUBE1) protein as an early prognosticmarker in predicting survival, resuscitation success, and good neurological outcome following cardiopulmonary resuscitation (CPR)in cardiac arrest patients.Material and Methods: Non-traumatic cardiac arrest patients presenting to the emergency department over a six-month period wereincluded in the study.
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Temel Bulgular & Veri:Blood specimens were collected for SCUBE1 measurement at the start of CPR.
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Sonuç & Katkı:However, comparison of the patient groups with good andpoor neurological prognosis in terms of SCUBE1 levels at the start of CPR revealed that SCUBE1 levels were twice as high in the poorneurological prognosis group as in the good neurological prognosis group, although the difference was not statistically significant.Conclusion: SCUBE1 levels measured at the start of CPR are not sufficient for predicting post-CPR survival and good neurologicaloutcome.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: To evaluate the usefulness of Signal Peptide-CUB-EGF Domain-Containing Protein-1 (SCUBE1) protein as an early prognosticmarker in predicting survival, resuscitation success, and good neurological outcome following cardiopulmonary resuscitation (CPR)in cardiac arrest patients.Material and Methods: Non-traumatic cardiac arrest patients presenting to the emergency department over a six-month period wereincluded in the study. Blood specimens were collected for SCUBE1 measurement at the start of CPR. SCUBE1 levels investigated atthe start of CPR were compared, and their usefulness in predicting patients with long-term survival and exhibiting good neurologicalprognosis was evaluated.Results: The study group consisted of 65 non-traumatic cardiac arrest patients. Sustained return of spontaneous circulation (ROSC)was achieved in 26 (40%) of these 65 patients, and five (7.7%) cases concluded with good neurological prognosis after three months.Comparison of the patient groups with and without sustained ROSC in terms of SCUBE1 levels investigated at the start of CPRrevealed no statistically significant difference between them (p=0.462). However, comparison of the patient groups with good andpoor neurological prognosis in terms of SCUBE1 levels at the start of CPR revealed that SCUBE1 levels were twice as high in the poorneurological prognosis group as in the good neurological prognosis group, although the difference was not statistically significant.Conclusion: SCUBE1 levels measured at the start of CPR are not sufficient for predicting post-CPR survival and good neurologicaloutcome.

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Bu Makaleye Atıf Yap

MENTEŞE, A., AYGÜN, A., ALTUNTAŞ, G., ÖZŞAHİN, F., TATLI, Ö., TÜREDİ, S., DEMİR, S., TOP, A. A., ARDIÇ, Ş., ABANOZ, B. (2022). An investigation of the use of SCUBE1 protein as an early prognostic marker in predicting prognosis after cardiopulmonary resuscitation in cardiac arrest patients. Annals of Medical Research, Cilt: 27 - Sayı: 8, 2118–2123. https://ajindex.com/articles/446436

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Kaynakça (12)

  1. AD Friendlander, JM Hirshon. Basic Cardiopulmonary Resuscitation. In: Tintinalli JE, ed. Tintinalli’s Emergency Medicine: A Comprehensive Study Guide. 8.edition. USA. McGraw-Hill Education 2016. p.151-6
  2. Anyfantakis ZA, Baron G, Aubry P, et al. Acute coronary angiographic findings in survivors of out-of-hospital cardiac arrest. Am Heart J 2009;157:312-8
  3. Neumar RW, Shuster M, Callaway CW, et al. Part 1: executive summary: 2015 american heart association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2015;132:315-67
  4. Turedi S, Gunduz A, Mentese A, et al. Investigation of the possibility of using ischemia-modified albumin as a novel and early prognostic marker in cardiac arrest patients after cardiopulmonary resuscitation. Resuscitation 2009;80:994-9
  5. Calderon LM, Guyette FX, Doshi AA, et al. Post Cardiac Arrest S. Combining NSE and S100B with clinical examination findings to predict survival after resuscitation from cardiac arrest. Resuscitation 2014;85:1025-9
  6. Einav S, Kaufman N, Algur N,et al. Modeling serum biomarkers S100 beta and neuron-specific enolase as predictors of outcome after out-of-hospital cardiac arrest: an aid to clinical decision making. J Am Coll Cardiol 2012;60:304-11
  7. Shinozaki K, Oda S, Sadahiro T, et al. S-100B and neuron-specific enolase as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation: a systematic review. Crit Care 2009;13:R121
  8. Gul SS, Huesgen KW, Wang KK, et al. Prognostic utility of neuroinjury biomarkers in post out-of-hospital cardiac arrest (OHCA) patient management. Med Hypotheses 2017;105:34-47
  9. Mongardon N, Arnaout M, Geri G, Chenevier-Gobeaux C, et al. Usefulness of early plasma S-100B protein and neuron-specific enolase measurements to identify cerebrovascular etiology of out-of-hospital cardiac arrest. Resuscitation 2018;130:61-6
  10. Callaway CW, Donnino MW, Fink EL, et al. Part 8: Postcardiac arrest care: 2015 American heart association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2015;132:465-82
  11. Turkmen S, Eryigit U, Karaca Y, et al. Diagnostic value of plasma signal peptide-Cub-Egf domain-containing protein-1 (SCUBE-1) in an experimental model of acute ischemic stroke. Am J Emerg Med 2015;33:262- 5
  12. Turedi S, Tatli O, Alver A, et al. The diagnostic value of plasma SCUBE1, a novel biomarker of platelet activation, in t