KaydedilenlerDerginizi ekleyin

Dergiler / Annals of Medical Research / 2022 / Cilt: 29 - Sayı: 5

Investigation of antioxidant effect of silibinin molecule on U-2 OS cells induced by hydrogen peroxide

Emre DİRİCAN
Emre DİRİCAN
‪Meral URHAN KÜÇÜK
Hasret ECEVİT
Kübra GÜNDÜZ
Sayfa
502–508
Yayın Tarihi
2022-10-12
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Results: CAT activity and MDA level were observed to be higher in both H2O2 exposure groups compared to control group (p

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: Silibinin is one of the active constituent of silymarin, an extract of the Silybum marianum L. seeds.
📊
Temel Bulgular & Veri:In our study, we aimed to evaluate the effect of silibinin on U-2 OS cell proliferation and oxidative stress parameters catalase enzyme activity and MDA level.
💡
Sonuç & Katkı:Results: CAT activity and MDA level were observed to be higher in both H2O2 exposure groups compared to control group (p
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: Silibinin is one of the active constituent of silymarin, an extract of the Silybum marianum L. seeds. There are previous studies that have reported the antioxidant, antiinflammatory, anti-apoptotic and anti-carcinogenic effects of silibinin. However, the antioxidant effect of silibinin on bone cancer have been not evaluated before. In our study, we aimed to evaluate the effect of silibinin on U-2 OS cell proliferation and oxidative stress parameters catalase enzyme activity and MDA level. Materials and Methods: U-2 OS cells were exposed to H2O2 (0-800 µM H2O2, for 24 and 48 hours) to form an oxidative damaged cell model. Moreover, the cells were exposed to silibinin (0-100 µM) for 24 hours. Malondialdehyde (MDA) level and antioxidant enzyme catalase (CAT) activity were determined by spectrophotometric analysis. Results: CAT activity and MDA level were observed to be higher in both H2O2 exposure groups compared to control group (p

🔖

Bu Makaleye Atıf Yap

DİRİCAN, E., DİRİCAN, E., KÜÇÜK, ‪. U., ECEVİT, H., GÜNDÜZ, K. (2022). Investigation of antioxidant effect of silibinin molecule on U-2 OS cells induced by hydrogen peroxide. Annals of Medical Research, Cilt: 29 - Sayı: 5, 502–508. https://ajindex.com/articles/446170

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (14)

  1. Durfee RA, Mohammed M, Luu HH. Review of Osteosarcoma and Current Management. Rheumatology and therapy 2016;3(2):221-43
  2. Broadhead ML, Clark JC, Myers DE, et al. The molecular pathogenesis of osteosarcoma: a review. Sarcoma 2011;2011:959248
  3. Gupta RK, Patel AK, Shah N, et al. Oxidative stress and antioxidants in disease and cancer: a review. Asian Pacific journal of cancer prevention: APJCP 2014;15(11):4405-9
  4. Srinivas US, Tan BWQ, Vellayappan BA, et al. ROS and the DNA damage response in cancer. Redox biology 2019;25:101084
  5. Khan MS, Dwivedi S, Priyadarshini M, et al. Ribosylation of bovine serum albumin induces ROS accumulation and cell death in cancer line (MCF-7). European biophysics journal: EBJ 2013;42(11-12):811-8
  6. Harris IS, DeNicola GM. The Complex Interplay between Antioxidants and ROS in Cancer. Trends in cell biology 2020;30(6):440-51
  7. Soleimani V, Delghandi PS, Moallem SA, et al. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Phytotherapy research: PTR 2019;33(6):1627- 38
  8. Nigmatullaev BA, Duschanova GM, Abdurahmonov BA, et al. Anatomical Structure of Vegetative and Generative Organs of Silybum marianum (L.) Gaertn. (Fam. Asteraceae). American Journal of Plant Sciences 2018;9: 38-43
  9. Valková V, Ďúranová H, Bilčíková J, et al. Milk Thistle (Silybum Marianum): A Valuable Medicinal Plant With Several Therapeutic Purposes. J Microbiol Biotech Food Sci 2020;9(4):836-43
  10. AbouZid SF, Chen SN, Pauli GF. Silymarin content in Silybum marianum populations growing in Egypt. Industrial crops and products 2016;83:729-37
  11. Jiang HH, Yan FS, Shen L, et al. Silymarin versus Silibinin: Differential Antioxidant and Neuroprotective Effects against H2O2- induced Oxidative Stress in PC12 Cells. Natural product communications 2016;11(5):633-6
  12. Tong WW, Zhang C, Hong T, et al. Silibinin alleviates inflammation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats. Scientific reports 2018;8(1):3241
  13. Murali Iyangar R, Devaraj E. Silibinin Triggers the Mitochondrial Pathway of Apoptosis in Human Oral Squamous Carcinoma Cells. Asian Pacific journal of cancer prevention: APJCP 2020;21(7):1877-82
  14. Deep G, Singh RP, Agarwal C, et al. Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibin