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Dergiler / Anatomy / 2019 / Cilt: 13 - Sayı: 2

Hibiscus ameliorates salt-induced carotid intima-media thickness in albino rats

Fidel O. GWALA
William O. SIBUOR
Beda O. OLABU
Anne N. PULEI
Julius A. OGENGO
Dergi
Anatomy
Sayfa
92–97
Yayın Tarihi
2022-10-11
DOI
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In Hibiscus sabdariffa extract fed rats, theCIMT decreased to 542.85 μm (p

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Amaç & Hipotez:The carotid intima-media thickness (CIMT) is a known biomarker of clinical and subclinical cardiovascular eventsand evaluation of therapeutic action.
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Temel Bulgular & Veri:This studytherefore, investigated the effects of hibiscus extract on CIMT in rats fed with a high-salt diet.Methods: Young albino rats (Rattus norvegicus) were divided into three groups: (A) high-salt diet alone, (B) high-salt diet andHibiscus sabdariffa extract and (C) control group fed a normal diet for 8 weeks.
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Sonuç & Katkı:In Hibiscus sabdariffa extract fed rats, theCIMT decreased to 542.85 μm (p
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

The carotid intima-media thickness (CIMT) is a known biomarker of clinical and subclinical cardiovascular eventsand evaluation of therapeutic action. Excessive salt directly causes changes in the common carotid intima and media layersand has been linked to hypertensive disease resulting to changes on vascular structure. Hibiscus sabdariffa is a traditionalherbal drink with antihypertensive effects. The anatomical aspects of its effects however, are largely unknown. This studytherefore, investigated the effects of hibiscus extract on CIMT in rats fed with a high-salt diet.Methods: Young albino rats (Rattus norvegicus) were divided into three groups: (A) high-salt diet alone, (B) high-salt diet andHibiscus sabdariffa extract and (C) control group fed a normal diet for 8 weeks. Specimens from carotid arteries of rats were fixated and processed for paraffin embedding. Seven-micrometer thick sections were stained with Hematoxylin and Eosin stain andexamined under light microscopy. Morphometric measurements were taken to determine the CIMT.Results: High-salt diet increased CIMT from 497.86 μm to 697.85 μm in 8 weeks. In Hibiscus sabdariffa extract fed rats, theCIMT decreased to 542.85 μm (p

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Bu Makaleye Atıf Yap

GWALA, F. O., SIBUOR, W. O., OLABU, B. O., PULEI, A. N., OGENGO, J. A. (2022). Hibiscus ameliorates salt-induced carotid intima-media thickness in albino rats. Anatomy, Cilt: 13 - Sayı: 2, 92–97. https://ajindex.com/articles/439461

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Kaynakça (13)

  1. Aaron KJ, Sanders PW. Role of dietary salt and potassium intake in cardiovascular health and disease: a review of the evidence. Mayo Clinic Proc 2013;88:987–95
  2. He FJ, Li J, MacGregor GA. Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta – analysis of randomissed trials. BMJ 2013;346:f1325
  3. Zhao X, Yang X, Zhang X, Li Y, Zhao X, Ren L, Wang L, Gu C, Zhu Z, Han Y. Dietary salt intake and coronary atherosclerosis in patients with prehypertension. J Clin Hypertens 2014;16:575–80
  4. Xin Z, Xia Xu Y, Cheng Hui Y, Xiao Lin Z, Ya Ling H. Dietary salt intake and coronary atherosclerosis in patients with prehypertension. Heart 2015; ASSA 14–11–03
  5. Baldo MP, Rodrigues SL, Mill JG. High salt intake is a multifaceted cardiovascular disease: new support from cellular and molecular evidence. Heart Fail Rev 2015;20:461–74
  6. Chrysant SG. Effects of high salt intake on blood pressure and cardiovascular disease: the role of Cox inhibitors. Clin Cardiol 2016;39: 240–2
  7. Njoroge JN, Khoudary SRE, Fried LF, Barinas-Mitchell E, SuttonTyrrell K. High urinary sodium is associated with increased carotid intima-media thickness in normotensive overweight and obese adults. Am J Hypertens 2011;24:70–6
  8. Lorenz MW, Karbstein P, Markus HS, Sitzer M. High-sensitivity C-reactive protein is not associated with carotid intima-media progression: the carotid atherosclerosis progression study. Stroke 2007; 38:1774–9
  9. World Health Organization. Reducing salt intake in populations: report of a WHO forum and technical meeting, 5–7 October 2006, Paris, France
  10. Serban C, Sahebkar A, Ursoniu S, Andrica F, Banach M. Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials. J Hypertens 2015;33:1119–27
  11. Hopkins AL, Lamm MG, Funk JL, Ritenbough C. Hibiscus sabdariffa L in the treatment of hypertension and hyperlipidemia: a comprehensive review of human and animal studies. Fitoterapia 2013;85:84–94
  12. Seujange Y, Leelahavanichkul A, Yisarakun W, Khawsuk W, Meepool A, Phamonleatmongkol P, Saechau W, Onlamul W, Tantiwarattanatikul P, Oonsook W, Eiam-Ong S, Eiam-Ong S. Hibiscus sabdariffa Linnaeus aqueous extracts attenuate the progression of renal injury in 5/6 nephrectomy rats. Ren Fail 2013;35:118– 25
  13. Guardiola S, Mach N. Therapeutic potential of Hibiscus sabdariffa: a review of the scientific evidence. [Article in Spanish] Endocrinol Nut