The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study

Amaç & Hipotez:Objective: To compare intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) serum levels between patients with stable (SAP) and unstable angina pectoris (USAP) undergoing coronary angiography (CAG), investigate effects of CAG on ICAM-1, VCAM-1 levels in SAP USAP patients; probable different effects of non-ionic radiocontrast media (RCM), iso-osmotic iodixanol and low osmolar iopamidol, on , these adhesion molecules (AM).

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Temel Bulgular & Veri:Methods: In this randomized, prospective study, 2 groups consisting of patients with SAP (n=22) and USAP (n=22) undergoing CAG were included.

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Sonuç & Katkı:In USAP-iodixanol subgroup; only VCAM-1 (p

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: To compare intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) serum levels between patients with stable (SAP) and unstable angina pectoris (USAP) undergoing coronary angiography (CAG), investigate effects of CAG on ICAM-1, VCAM-1 levels in SAP USAP patients; probable different effects of non-ionic radiocontrast media (RCM), iso-osmotic iodixanol and low osmolar iopamidol, on , these adhesion molecules (AM). Methods: In this randomized, prospective study, 2 groups consisting of patients with SAP (n=22) and USAP (n=22) undergoing CAG were included. For halves of each group iopamidol, for the other halves iodixanol were used as RCM, in turn for randomization. The patients were divided into 4 subgroups according to clinical presentations and used RCM(SAP-iodixanol, SAP-iopamidol USAP-iodixanol, USAP-iopamidol). ICAM-1, VCAM-1 levels were measured just before and 12 hours after CAG. Repeated measurements were compared with two-way ANOVA test. Results: Baseline VCAM-1 concentration was higher in USAP group than SAP group (p=0.001). ICAM-1, VCAM-1 concentrations increased signifi- cantly following CAG in SAP USAP groups. ICAM-1, VCAM-1 concentration increments; didn’t reach statistical significance in SAP-iodixanol sub- , group, reached a borderline significance in SAP-iopamidol subgroup (p=0.06, p=0.06). In USAP-iodixanol subgroup; only VCAM-1 (p

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Bu Makaleye Atıf Yap

AYYILDIZ, F. A., BAYATA, S., SEMERCİ, T., YEŞİL, M., TOKLU, O., ARIKAN, E., YAKAR, S. T., KÖSEOĞLU, M., KOCAĞRA, İ. Y. (2022). The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study. Anadolu Kardiyoloji Dergisi, Cilt: 14 - Sayı: 2, 156–161. https://ajindex.com/articles/436001

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