KaydedilenlerDerginizi ekleyin

Dergiler / Zeynep Kamil medical journal (Online) / 2021 / Cilt: 52 - Sayı: 1

Prenatal diagnosis and management of hypoplastic left heart syndrome: Single center results

Gürcan TÜRKYILMAZ
Yunus Emre PURUT
Sayfa
16–20
Yayın Tarihi
2022-10-12
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Prenatal diagnosis allows the family for the fate of pregnancy and planned delivery in a tertiary center

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objective: Hypoplastic left heart syndrome (HLHS) is the most common reason for neonatal deaths among congenital heart defects.
📊
Temel Bulgular & Veri:Material and Methods: The records of patients diagnosed with HLHS evaluated between March 2017 and April 2020.
💡
Sonuç & Katkı:Prenatal diagnosis allows the family for the fate of pregnancy and planned delivery in a tertiary center
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:2017 Verileri
⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: Hypoplastic left heart syndrome (HLHS) is the most common reason for neonatal deaths among congenital heart defects. Numerous studies showed that prenatal diagnosis improves prognosis. We aimed to review the prenatal assessment of associated extracardiac anomalies, postnatal outcomes, and surgical management in cases of HLHS that were detected in our center. Material and Methods: The records of patients diagnosed with HLHS evaluated between March 2017 and April 2020. A detailed anatomy scan was performed, and karyotype analysis was recommended to all patients. Due to poor perinatal prognosis, termination of pregnancy (TOP) was offered an option to families. Serial ultrasonographic examinations every 2–4 weeks. Postnatal echocardiography was performed, and the prenatal diagnosis was confirmed in all offspring. Surgical outcomes were recorded. Results: Sixteen patients were recruited in our study. The mean gestational age at diagnosis was 20.2±5.1 weeks. About 68.7% of cases were defined as classical type HLHS, and the remaining 31.3% were determined as variant type HLHS. TOP was performed in 9 (56.7%) patients. The mean follow-up interval was 16.4±4.7 months. Urge septostomy was performed in 2 (28.5%) cases after birth due to foramen ovale restriction. Three (42.8%) cases died before the first operation. Norwood procedure was performed in 4 (57.1%) cases. Two cases died after this operation. Glenn shunt and Fontan procedure were performed in the remaining two offspring. The total survival rate was 28.5%. Conclusion: HLHS has high perinatal morbidity and mortality. Prenatal diagnosis allows the family for the fate of pregnancy and planned delivery in a tertiary center

🔖

Bu Makaleye Atıf Yap

TÜRKYILMAZ, G., PURUT, Y. E. (2022). Prenatal diagnosis and management of hypoplastic left heart syndrome: Single center results. Zeynep Kamil medical journal (Online), Cilt: 52 - Sayı: 1, 16–20. https://ajindex.com/articles/426172

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (12)

  1. Rychik J. Hypoplastic left heart syndrome: From in utero diagnosis to school age. Semin Fetal Neonatal Med 2005; 10(6): 553–66
  2. Gordon BM, Rodriguez S, Lee M, Chang RK. Decreasing number of deaths of infants with hypoplastic left heart syndrome. J Pediatr 2008; 153(3): 354–8
  3. Karamlou T, Diggs BS, Ungerleider RM, Welke KF. Evolution of treatment options and outcomes for hypoplastic left heart syndrome over an 18-year period. J Thorac Cardiovasc Surg 2010; 139(1): 119–26; discussion 126–7
  4. Fixler DE, Nembhard WN, Salemi JL, Ethen MK, Canfield MA. Mortality in first 5 years in infants with functional single ventricle born in Texas, 1996 to 2003. Circulation 2010; 121(5): 644–50
  5. Reller MD, Strickland MJ, Riehle-Colarusso T, Mahle WT, Correa A. Prevalence of congenital heart defects in metropolitan Atlanta, 1998- 2005. J Pediatr 2008; 153(6): 807–13
  6. Natowicz M, Chatten J, Clancy R, Conard K, Glauser T, Huff D, et al. Genetic disorders and major extracardiac anomalies associated with the hypoplastic left heart syndrome. Pediatrics 1988; 82(5): 698–706
  7. Morris SA, Ethen MK, Penny DJ, Canfield MA, Minard CG, Fixler DE, et al. Prenatal diagnosis, birth location, surgical center, and neonatal mortality in infants with hypoplastic left heart syndrome. Circulation 2014; 129(3): 285–92
  8. Morris SA, Ethen MK, Penny DJ, Canfield MA, Minard CG, Fixler DE, et al. Prenatal diagnosis, birth location, surgical center, and neonatal mortality in infants with hypoplastic left heart syndrome. Circulation 2014; 129(3): 285–92. 9. van Velzen CL, Clur SA, Rijlaarsdam ME, Bax CJ, Pajkrt E, Heymans MW, et al. Prenatal detection of congenital heart disease--results of a national screening programme. BJOG 2016; 123(3): 400–7
  9. Liu MY, Zielonka B, Snarr BS, Zhang X, Gaynor JW, Rychik J. Longitudinal assessment of outcome from prenatal diagnosis through Fontan operation for over 500 fetuses with single ventricle-type congenital heart disease: The Philadelphia fetus-to-Fontan cohort study. J Am Heart Assoc 2018; 7(19): e009145
  10. Beroukhim RS, Gauvreau K, Benavidez OJ, Baird CW, LaFranchi T, Tworetzky W. Perinatal outcome after prenatal diagnosis of single-ventricle cardiac defects. Ultrasound Obstet Gynecol 2015; 45(6): 657–63
  11. Thakur V, Munk N, Mertens L, Nield LE. Does prenatal diagnosis of hypoplastic left heart syndrome make a difference? A systematic review. Prenat Diagn 2016; 36(9): 854–63
  12. Benson DW, Martin LJ, Lo CW. Genetics of hypoplastic l