KaydedilenlerDerginizi ekleyin

Dergiler / Sigma Mühendislik ve Fen Bilimleri Dergisi / 2017 / Cilt: 35 - Sayı: 2

HYDROXYL-FUNCTIONALIZED HYPERBRANCHED ALIPHATIC POLYESTERS BASED ON 1,1,1-TRIS(HYDROXYMETHYL)PROPANE (TMP) AS A CORE MOLECULE: SYNTHESIS AND CHARACTERIZATION

Ayça BAL
Erdal CEVHER
Saadet Kevser PABUCCUOĞLU
Sayfa
239–251
Yayın Tarihi
2017-06-01
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It was concluded that new HBPs which were synthesized in this study have reasonable characteristics for hyperbranched polymers applications.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:The aim of this study is to synthesize and characterize the new hydroxyl-functionalized hyperbranched aliphatic polyesters with various generations for potential use in cancer therapy as targeted drug delivery system.
📊
Temel Bulgular & Veri:For this purpose, a series of novel hydroxyl-functionalized hyperbranched aliphatic polyesters (HBPs) based on 2,2-bis(hydroxymethyl)butyric acid (Bis-HBA) as AB2-type monomer and 1,1,1-tris(hydroxymethyl)propane (TMP) as B3 core molecule were synthesized via acid catalyzed polyesterification reaction in three different generations and named as HBP-2G, HBP-4G and HBP-5G.
💡
Sonuç & Katkı:It was concluded that new HBPs which were synthesized in this study have reasonable characteristics for hyperbranched polymers applications.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Hyperbranched aliphatic polyesters · dentritic polymer · hydroxyl-functionalized hyperbranched polyesters.

Abstract

The aim of this study is to synthesize and characterize the new hydroxyl-functionalized hyperbranched aliphatic polyesters with various generations for potential use in cancer therapy as targeted drug delivery system. For this purpose, a series of novel hydroxyl-functionalized hyperbranched aliphatic polyesters (HBPs) based on 2,2-bis(hydroxymethyl)butyric acid (Bis-HBA) as AB2-type monomer and 1,1,1-tris(hydroxymethyl)propane (TMP) as B3 core molecule were synthesized via acid catalyzed polyesterification reaction in three different generations and named as HBP-2G, HBP-4G and HBP-5G. The synthesis route was a simple pseudo-one-step reaction where AB2-type monomer and B3 core molecule are polycondensed in the presence of an acid catalyst. The chemical structures of the synthesized HBPs were confirmed by FTIR, 13C NMR and 1H NMR analysis. The degree of branching (DB) of the HBPs as calculated from 1H NMR results were between 0.87 and 0.92. These results showed that all synthesized HBPs had a high degree of branching. TGA measurements exhibited that all of HBPs had similar and good thermal stability. Glass transition temperatures (Tg) of samples were identified using DSC analysis and were found to be between 66.2 °C and 69.1 °C. Low generation HBPs have considerably higher solubility in organic solvents than high generation HBPs. All synthesized HBPs displayed extremely low water solubility but extremely high solubility in dimethyl sulfoxide. It was concluded that new HBPs which were synthesized in this study have reasonable characteristics for hyperbranched polymers applications.

🔖

Bu Makaleye Atıf Yap

BAL, A., CEVHER, E., PABUCCUOĞLU, S. K. (2017). HYDROXYL-FUNCTIONALIZED HYPERBRANCHED ALIPHATIC POLYESTERS BASED ON 1,1,1-TRIS(HYDROXYMETHYL)PROPANE (TMP) AS A CORE MOLECULE: SYNTHESIS AND CHARACTERIZATION. Sigma Mühendislik ve Fen Bilimleri Dergisi, Cilt: 35 - Sayı: 2, 239–251. https://ajindex.com/articles/418977

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (15)

  1. Yan D., Gao C., Frey H., (2011) Hyperbranched polymers: synthesis, properties, and applications. John Wiley & Sons: Hoboken, New Jersey
  2. Johansson M., Glauser T., Jansson A., Hult A., Malmström E., Claesson H., (2003) Design of coating resins by changing the macromolecular architecture: solid and liquid coating systems, Prog. Org. Coat. 48(2), 194-200
  3. Johansson M., Glauser T., Rospo G., Hult A. J., (2000) Radiation curing of hyperbranched polyester resins, Appl. Polym. Sci. 75(5), 612-618
  4. Johansson K., Bergman T., Johansson M., (2008) Hyperbranched aliphatic polyesters and reactive diluents in thermally cured coil coatings, ACS Appl. Mater. Inter. 1(1), 211-217
  5. Haxton K. J., Burt H. M., (2008) Hyperbranched polymers for controlled release of cisplatin, Dalton Trans. 43, 5872-5875
  6. Kolhe P., Misra E., Kannan R. M., Kannan S., Lieh-Lai M., (2003) Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers, Int. J. Pharm. 259(1), 143-160
  7. Gao C., Yan D., (2004) Hyperbranched polymers: from synthesis to applications, Prog. Polym. Sci. 29(3), 183–275
  8. Seiler M., (2006) Hyperbranched polymers: Phase behavior and new applications in the field of chemical engineering, Fluid Phase Equilibr. 241(1), 155-174
  9. Tomalia D. A., Fréchet J. M., (2002) Discovery of dendrimers and dendritic polymers: a brief historical perspective, J. Polym. Sci. A2. 40(16), 2719-2728
  10. Bosman A. W., Janssen H. M., Meijer E. W., (1999) About dendrimers: structure, physical properties, and applications, Chem. Rev. 99(7), 1665-1688
  11. Ihre H., Hult A., Söderlind E. J., (1996) Synthesis, characterization, and 1H NMR self-diffusion studies of dendritic aliphatic polyesters based on 2, 2-bis (hydroxymethyl) propionic acid and 1, 1, 1-tris (hydroxyphenyl) ethane, Am. Chem. Soc. 118(27), 6388-6395
  12. Freemantle M., (1999) Blossoming of dendrimers, Chem. Eng. News. 77(44), 27-35
  13. Zagar E., Zigon M., (2011) Aliphatic hyperbranched polyesters based on 2, 2-bis (methylol) propionic acid—Determination of structure, solution and bulk properties, Prog. Polym. Sci. 36(1), 53–88
  14. Schmaljohann D., Komber H., Voit B. I., (1999) Conversion dependence of the structural units and the degree of branching of a hyperbranched polyester based on 4, 4-bis-(4′-hydroxyphenyl) pentanoic acid determined by NMR spectroscopy, Acta Polym. 50(5-6), 196–204
  15. Scholl M., Nguyen T. Q., Bruchmann B., Klok H. A., (2007) Controlling p