Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightDifferences between thenumbers of other histological types of lung cancer and the numbers of driver mutations in the 2 groups of patients were not signifiant.CONCLUSION: The differences in the rate of lung cancer and prevalence of EGFR driver mutations between the patients with pureCOPD and those with ACO were not signifiant.
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Özet
OBJECTIVES: Chronic obstructive pulmonary disease (COPD) increases the risk of lung cancer. The relationships between COPD andAsthma COPD Overlap (ACO), and between the histopathological types of lung cancer and driver mutations remain unclear and needfurther study. The aim of this retrospective study was to examine the relationships between the histopathological type, frequency of epidermal growth factor receptor (EGFR) driver mutations, and anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangements in thelung cancers of patients with COPD and ACO.MATERIALS AND METHODS: Patients with pure COPD (n=198) or ACO (n=318) who were admitted to our hospital were reviewedretrospectively.RESULTS: Lung cancers were identifid in 43 (21.7%) patients with pure COPD and 54 (17.0%) patients with ACO. The following lungcancers types were observed: patients with pure COPD had 19 (44.2%) adenocarcinomas, 13 (30.2%) squamous cell lung carcinomas(SCC), 8 (18.6%) small cell lung carcinomas (SCLC); patients with ACO had 23 (42.6%) adenocarcinomas, 23 (42.6%) SCC, 2 (3.70%)SCLC. SCLC was signifiantly more prevalent in patients with pure COPD (p<0.05) than in those with ACO. Differences between thenumbers of other histological types of lung cancer and the numbers of driver mutations in the 2 groups of patients were not signifiant.CONCLUSION: The differences in the rate of lung cancer and prevalence of EGFR driver mutations between the patients with pureCOPD and those with ACO were not signifiant.