Dergiler / Türk Biyokimya Dergisi / 2021 / Cilt: 46 - Sayı: 4

Effects of eccentric exercise-induced delayed onset muscle soreness on endoplasmic reticulum stress-related markers

[Eksantrik egzersize bağlı gecikmiş kas ağrısının endoplazmik retikulum stresle ilişkili belirteçler üzerindeki etkileri]

Sayfa
407–414
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: ER is activated and ER stress occurred, due to increases in IL6, PTX3 and apelin levels after the test protocol concluded that a single vigorous eccentric exercise should be avoided in harmful effect on health as parallel with Physical Activity Guidelines.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Short Communications: Apelin, pentraxin3 (PTX3), and interleukin6 (IL6) parameters are known as inflammation markers and found to be related to endoplasmic reticulum (ER) stress.
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Temel Bulgular & Veri:Objectives and Methods: ER stress and DOMS-related blood markers, maximal strength level, and rate of perceived exertion using the visual analog scale (VAS) were assessed before, immediately after, 24, 48, and 72 h after the muscle damage protocol.
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Sonuç & Katkı:Conclusion: ER is activated and ER stress occurred, due to increases in IL6, PTX3 and apelin levels after the test protocol concluded that a single vigorous eccentric exercise should be avoided in harmful effect on health as parallel with Physical Activity Guidelines.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Short Communications: Apelin, pentraxin3 (PTX3), and interleukin6 (IL6) parameters are known as inflammation markers and found to be related to endoplasmic reticulum (ER) stress. The aimof the studywas to investigate the effect of eccentric exercise-induced delayed onset muscle soreness (DOMS) on ER stress-related markers in young athletes. Objectives and Methods: ER stress and DOMS-related blood markers, maximal strength level, and rate of perceived exertion using the visual analog scale (VAS) were assessed before, immediately after, 24, 48, and 72 h after the muscle damage protocol. Results: IL6 peaked 24 h after while creatine kinase and lactate dehydrogenase enzyme levels reached their peaks at 72 h after the protocol. The level of apelin continued to increase throughout the four measurements, and PTX3 peaked at 24 h, and then declined to the levels before the protocol but the differences were not significant. The significant decrease in the strength and the significant increase in VAS continued 48 h after the protocol. Conclusion: ER is activated and ER stress occurred, due to increases in IL6, PTX3 and apelin levels after the test protocol concluded that a single vigorous eccentric exercise should be avoided in harmful effect on health as parallel with Physical Activity Guidelines.

Abstract

Giriş: Apelin, pentraxin 3 (PTX3) ve interlökin 6 (IL6) parametreleri inflamasyon belirteçleri olarak bilinir ve endoplazmik retikulum (ER) stresi ile ilişkili olduğu bulunmuştur. Bu çalışmanın amacı, eksentrik egzersize bağlı gecikmiş kas ağrısının (DOMS) genç sporcularda ER stres ile ilişkili belirteçler üzerindeki etkisini araştırmaktı. Materyal ve yöntem: ER stresi ve DOMS ile ilgili kan belirteçleri, maksimum kuvvet düzeyi ve görsel analog ölçeği (VAS) kullanılarak algılanan efor oranı, izokinetik dinamometrede eksantrik kasılmalar ile oluşturulan kas hasarı protokolünden önce, hemen sonra, 24, 48 ve 72 saat sonra değerlendirildi. Bulgular: IL6 DOMS protokolünden 24 saat sonra, kreatin kinaz (CK) ve laktat dehidrojenaz (LDH) enzim seviyeleri 72 saat sonra zirve yaptı. Apelin seviyesi dört ölçüm boyunca artmaya devam etti ve PTX3 24 saatte zirve yaptı, ardından protokolden önceki seviyelere düştü ancak farklar anlamlı değildi. Maksimal kuvvetteki önemli düşüş ve VAS’daki önemli artış protokolden 48 saat sonra devam etti. Sonuç: Kas hasar testi protokolünden sonraki mevcut gözlemler IL6, PTX3 ve apelin düzeylerindeki artışlara bağlı olarak ER’nin aktive olduğunu ve ER stresinin oluştuğunu göstermektedir. Fiziksel Aktivite Rehberine paralel olarak, tek bir şiddetli eksentrik egzersizden sağlık üzerinde zararlı etkisi nedeniyle kaçınılması gerektiği sonucuna varılmıştır.

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Bu Makaleye Atıf Yap

VAROL, S. R., NALÇAKAN, G. R., DOĞRU, Y., AKYÜZ, M., TAŞ, M., ULMAN, C. (2021). Effects of eccentric exercise-induced delayed onset muscle soreness on endoplasmic reticulum stress-related markers. Türk Biyokimya Dergisi, Cilt: 46 - Sayı: 4, 407–414. https://ajindex.com/articles/414092

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Kaynakça (15)

  1. Rutkowski DT, Kaufman RJ. A trip to the ER: coping with stress. Trends Cell Biol 2004;14:20–8
  2. Kaufman RJ. Orchestrating the unfolded protein response in health and disease. J Clin Invest 2002;110:1389–98
  3. Chen H, Zheng C, Zhang X, Li J, Li J, Zheng L, et al. Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice. Peptides 2011;32:1634–39
  4. Jensen MP, McFarland CA. Increasing the reliability and validity of pain intensity measurement in chronic pain patients. Pain 1993;55: 195–203
  5. Castell JV, Gómez‐lechón MJ, David M, Fabra R, Trullenque R, Heinrich PC. Acute‐phase response of human hepatocytes: regulation of acute‐phase protein synthesis by interleukin‐6. Hepatology 1990;12:1179–86
  6. Mantovani A, Garlanda C, Doni A, Bottazzi B. Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3. J Clin Immunol 2008;28:1–13
  7. Li YX, Ren YL, Fu HJ, Zou L, Yang Y, Chen Z. Hepatitis B virus middle protein enhances IL-6 production via p38 MAPK/NF-κB pathways in an ER stress-dependent manner. PloS One 2016;11: e0159089
  8. Liong S, Lappas M. Endoplasmic reticulum stress regulates inflammation and insulin resistance in skeletal muscle from pregnant women. Mol Cell Endocrinol 2016;425:11–25
  9. Hwang N, Kwon MY, Cha JB, Chung SW, Woo JM. Tunicamycininduced endoplasmic reticulum stress upregulates the expression of pentraxin 3 in human retinal pigment epithelial cells. Kor J Ophthalmol 2016;30:468–78
  10. Besse-Patin A, Montastier E, Vinel C, Castan-Laurell I, Louche K, Dray C, et al. Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine. Int J Obes 2014;38:707
  11. Shaibani S, Shemshaki A, Hanachi P. The effect of rast exercise on plasma levels of apelin and blood pressure in elite women runner. Qom Univ Med Sci J 2011;6:27–31
  12. Northoff H, Berg A. Immunologic mediators as parameters of the reaction to strenuous exercise. Int J Sports Med 1991;12:9–15
  13. Papanicolaou D, Petrides J, Tsigos C, Bina S, Kalogeras K, Wilder R, et al. Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. Am J Physiol Endocrinol Metab 1996;271:601–05
  14. Deldicque L, Hespel P, Francaux M. Endoplasmic reticulum stress in skeletal muscle: origin and metabolic consequences. Exerc Sport Sci Rev 2012;40:43–9
  15. Clarkson PM, Nosaka K, Braun B. Muscle function after exerciseinduced mus