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Dergiler / Turkish Journal of Hematology / 2007 / Cilt: 24 - Sayı: 2

Acute immune thrombocytopenic purpura in children

Abdul REHMAN
Sayfa
41–51
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The best treatment seems to be observation except in severe cases.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Immune thrombocytopenic purpura (ITP) in children is usually a benign and self-limiting disorder.
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Temel Bulgular & Veri:It may follow a viral infection or immunization and is caused by an inappropriate response of the immune system.
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Sonuç & Katkı:The best treatment seems to be observation except in severe cases.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Rho(D) immun globulin · Kemik iliği · Steroidler

Özet

Immune thrombocytopenic purpura (ITP) in children is usually a benign and self-limiting disorder. It may follow a viral infection or immunization and is caused by an inappropriate response of the immune system. The diagnosis relies on the exclusion of other causes of thrombocytopenia. This paper discusses the differential diagnoses and investigations, especially the importance of bone marrow aspiration. The course of the disease and incidence of intracranial hemorrhage are also discussed. There is substantial discrepancy between published guidelines and between clinicians who like to over-treat. The treatment of the disease ranges from observation to drugs like intravenous immunoglobulin, steroids and anti-D to splenectomy. The different modes of treatment are evaluated. The best treatment seems to be observation except in severe cases.

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Bu Makaleye Atıf Yap

REHMAN, A. (2007). Acute immune thrombocytopenic purpura in children. Turkish Journal of Hematology, Cilt: 24 - Sayı: 2, 41–51. https://ajindex.com/articles/413021

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Kaynakça (14)

  1. George JN,Woolf SH,Raskob GE,Wasser JS,Aledort LM, Ballem PJ, Blanchette VS, Bussel JB, Cines DB, Kelton JG, Lichtin AE, McMillan R, Okerbloom JA, Regan DH, Warrier I. Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood 1996;88:3-40
  2. Kuhne T, Buchanan GR, Zimmerman S, Michaels LA, Kohan R, Berchtold W, Imbach P. A prospective comparative study of 2540 infants and children with newly diagnosed idiopathic thrombocytopenic purpura (ITP) from the intercontinental childhood ITP study group. J Pediatr 2003;143:605-8
  3. Souid A, Sadowitz PD. Acute childhood immune thrombocytopenic purpura Diagnosis and treatment. Clin Pediatr 1995;34:487-94
  4. Hoyle C, Darbyshire P, Eden OB. Idiopathic thrombocytopenia in childhood. Edinburgh experience 1962- 82. Scot Med J 1986;31:174-9
  5. Bolton-Maggs PHB. Idiopathic thrombocytopenic purpura. Arch Dis Child 2000;83:220-2
  6. De Mattia D, Del Principe D, Del Vecchio GC, Jankovic M, Arrighini A, Giordano P, Menichelli A, Mori P, Zecca M, Pession A. Acute childhood idiopathic thrombocytopenic purpura: AIEOP consensus guidelines for diagnosis and treatment. Haematologica 2000;85:420-4
  7. Walker JH, Walker W. Idiopathic thrombocytopenic purpura in childhood. Arch Dis Childhood.1961; 36:649-57
  8. Jaybose S, Tugal OL, Ozkaynak MF, Sandoval C. Recurrent immune thrombocytopenic purpura in children. Pediatr Hematol Oncol 2006;23:677-82 9. Lilleyman JS. Management of childhood idiopathic thrombocytopenic purpura. Br J Haematol 1999;105:871-5
  9. Segal JB, Powe NR. Prevalence of immune thrombocytopenia: analyses of administrative data. J Thromb Haemost 2006;4:2377-83
  10. Bussel JB. Novel approaches to refractory immune thrombocytopenic purpura. Blood Rev 2002;16:31-6
  11. Chan H, Moore JC, Finch CN, Warkentin TE, Kelton JG. The IgG subclasses of platelet-associated autoantibodies directed against platelet glycoproteins IIb/IIIa in patients with idiopathic thrombocytopenic purpura. Br J Haematol 2003;122:818-24
  12. McMillan R. Autoantibodies and autoantigens in chronic immune thrombocytopenic purpura. Semin Hematol 2000;37:239-48
  13. Coetzee L.M, Pieters H, van Wyk V, Cooper S, Roodt J, De Reys S, Badenhorst P. The effect of monoclonal anti-human-platelet antibodies on platelet kinetics in a baboon model: IgG subclass dependency. Thromb Haemost 2000;83:148-56
  14. Prodinger WN, Wurzner R, Erdei A, Dierich M.P. Complement. In: Paul WE, ed. Fundam