Dergiler / Turkish Journal of Hematology / 2019 / Cilt: 36 - Sayı: 3

Long-term Dental Anomalies after Pediatric Cancer Treatment in Children

Kanser Tedavisi Gören Çocuklarda Uzun Süre Sonra Görülen Diş Anomalileri

Sayfa
155–161
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The frequencies of microdontia andhypodontia were increased even more when the patient was treatedfor cancer before 5 years of age.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objective: The aim of this study is to determine the frequency ofdental anomalies (DAs) (microdontia, hypodontia, hyperdontia, enameldefect, root malformation) in pediatric cancer patients at the ages <5years and between 5 and 7 years, and understand their relationshipwith the received therapy.Materials and Methods: Pediatric patients who were diagnosed withcancer and treated before the age of 7 years were investigated in acase- control design.
📊
Temel Bulgular & Veri:The study included 93 pediatric patients whoseages at diagnosis were between 9 months and 7 years and whosetreatments were completed before 5-8 years.
💡
Sonuç & Katkı:The frequencies of microdontia andhypodontia were increased even more when the patient was treatedfor cancer before 5 years of age.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: The aim of this study is to determine the frequency ofdental anomalies (DAs) (microdontia, hypodontia, hyperdontia, enameldefect, root malformation) in pediatric cancer patients at the ages <5years and between 5 and 7 years, and understand their relationshipwith the received therapy.Materials and Methods: Pediatric patients who were diagnosed withcancer and treated before the age of 7 years were investigated in acase- control design. The study included 93 pediatric patients whoseages at diagnosis were between 9 months and 7 years and whosetreatments were completed before 5-8 years. Group A consisted ofpatients in the age range of 9 months to 4 years and Group B consistedof patients in the age range of 5-7 years. Seventy-two siblings withcompatible dental age ranges were included in the control group. Forboth groups, intraoral examinations were performed and panoramicradiographs were taken.Results: Among the 93 pediatric patients, the mean age was9.54±1.25 (range: 8-13 years) and 48 (51.6%) patients were male.The most common diagnosis was hematologic malignancy with a rateof 65.5%. At least one DA was detected in 7 (9.7%) individuals ofthe control group and in 78 (83.9%) of the patient group. While thepatients in the study group had all kinds of DAs, those in the controlgroup had only enamel defects. The rates of microdontia (p=0.077)and hypodontia (p=0.058) were detected to be significantly higherin Group A than in Group B. Root malformation was more commonin patients receiving chemotherapy and radiotherapy than in thosereceiving only chemotherapy (p=0.006).Conclusion: In this study it was found that the pediatric patientswho received cancer treatment before the age of 7 years constituteda high-risk group for DAs. The frequencies of microdontia andhypodontia were increased even more when the patient was treatedfor cancer before 5 years of age.

Abstract

Amaç: Çalışmanın amacı <5 ve 5-7 yaş arası kanser tanısı alıp tedavi görmüş hastalarda diş anomalileri (DA) (mikrodonti, hipodonti, hiperdonti, mine kusuru, kök şekil bozukluğu) sıklığını belirlemek ve alınan tedavi ile ilişkini saptamaktır. Gereç ve Yöntemler: Kanser tanısı alıp 7 yaş öncesi tedavi görmüş çocuk hastalar olgu kontrol yöntemiyle araştırıldı. Kanser tedavisinin üzerinden en az 5-8 yıl geçmiş, tanı yaşı 9 ay ile 7 yıl arasında değişen, 93 hasta çalışmaya dahil edildi. Grup A 9 ay-4 yaş arasındaki hastalardan, Grup B 5-7 yaş arasındaki hastalardan oluşuyordu. Kontrol grubu olarak hastaların yaş aralığı uygun 72 kardeşi alındı. Hasta ve kontrol grubunun ağız içi muayeneleri yapıldı ve panoramik radyografileri alındı. Bulgular: Doksan üç hastanın yaş ortalaması 9,54±1,25 (dağılım 8-13 yıl) ve 48’i (%51,6) erkekti. En sık rastlanan tanı, %65,5 oranında hematolojik malignitelerdir. En az bir tane DA, hasta grubunun 78’inde (%83,9) ve kontrol grubunun 7’sinde (%9,7) saptandı. Çalışma grubundaki hastalarda her çeşit DA görülürken, kontrol grubunda sadece mine kusuru vardı. Grup A’da mikrodonti (p=0,077), hipodonti (p=0,058) oranlarının, Grup B’ye göre daha yüksek olduğu saptandı. Kök şekil bozukluğu kemoterapi ve radyoterapi alan hastalarda sadece kemoterapi alanlara göre daha fazla görüldü (p=0,006). Sonuç: Bu çalışmada 7 yaşından önce kanser tedavisi gören hastaların DA’lar yönünden yüksek riskli grup oluşturduğu saptanmıştır. Hastalar 5 yaşından önce kanser tedavisi gördüğünde mikrodontia ve hipodontinin sıklığı daha da artmıştır.

🔖

Bu Makaleye Atıf Yap

KILINÇ, G., BULUT, G., ERTUĞRUL, F., ÖREN, H., DEMİRAĞ, B., DEMİRAL, A., AKSOYLAR, S., KAMER, E. S., ELLİDOKUZ, H., OLGUN, N. (2019). Long-term Dental Anomalies after Pediatric Cancer Treatment in Children. Turkish Journal of Hematology, Cilt: 36 - Sayı: 3, 155–161. https://ajindex.com/articles/412717

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (15)

  1. Pedersen LB, Clausen, N, Schrøder H, Schmidt M, Poulsen S. Microdontia and hypodontia of premolars and permanent molars in childhood cancer survivors after chemotherapy. Int J Paediatr Dent 2012;22:239-243
  2. Lopez BC, Esteve CG, Perez MGS. Dental treatment considerations in the chemotherapy patient. J Clin Exp Dent 2010;3:31-42
  3. Minicucci EM, Lopes LF, Crocci AJ. Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia. Leuk Res 2003;27:45-50
  4. Goho C. Chemoradiation therapy: effect on dental development. Pediatr Dent 1993;15:6-12
  5. Tanaka H, Kurita H, Aizawa H, Kamata T. Agenesis of a large number of permanent teeth after treatment of neonatal leukemia. J Oral Maxillofac Surg Med Pathol 2015;27:558-561
  6. Carrillo, CM, Corrêa FN, Lopes NN, Fava M, Odone Filho V. Dental anomalies in children submitted to antineoplastic therapy. Clinics (Sao Paulo) 2014;69:433-437
  7. Proc P, Szczepańska J, Skiba A, Zubowska M, Fendler W, Młynarski W. Dental anomalies as late adverse effect among young children treated for cancer. Cancer Res Treat 2016;48:658-667
  8. Oğuz A, Cetiner S, Karadeniz C, Alpaslan G, Alpaslan C, Pinarli G. Long-term effects of chemotherapy on orodental structures in children with nonHodgkin’s lymphoma. Eur J Oral Sci 2004;112:8-11
  9. Hölttä P, Hovi L, Saarinen-Pihkala UM, Peltola J, Alaluusua S. Disturbed root development of permanent teeth after pediatric stem cell transplantation. Dental root development after SCT. Cancer 2005;103:1484-1493
  10. Nasman M, Forsberg CM, Dahllöf G. Long-term dental development in children after treatment for malignant disease. Eur J Orthod 1997;19:151- 159
  11. Doğan C, Haytaç C, Antmen B, Şaşmaz İ, Tanyeli A. Oral health in children with acute lymphoblastic leukemia and lymphoma. Turk J Hematol 2001;18:179-183
  12. Nasman M, Hammarström L. Influence of the antineoplastic agent cyclophosphamide on dental development in rat molars. Acta Odontol Scand 1996;54:287-294
  13. Nasman M, Hultenby K, Forsberg CM. A scanning electron microscopy study of disturbances in the developing rat molar induced by cyclophosphamide. Acta Odontol Scand 1997;55:186-191
  14. Dury DC, Roberts MW, Miser JS, Folio J. Dental root agenesis secondary to irradiation therapy in a case of rhabdomyosarcoma of the middle ear. Oral Surg Oral Med Oral Pathol 1984;57:595-599
  15. Kaste SC, Goodman P, Leisenring W, Stovall M, Hayashi RJ, Yeazel M, Beiraghi S, Hudson MM, Sklar CA, Robison LL, Baker KS. Impac