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Dergiler / Turkish Journal of Pediatrics / 2021 / Cilt: 63 - Sayı: 1

Fecal elastase levels in children diagnosed with functional abdominal pain-not otherwise specified

Burcu GÜVEN
Nuriye Burçin TURAN
Ahmet Fayik ÖNER
Kamuran KARAMAN
Mecnun ÇETİN
Sayfa
102–108
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

FE-1 levels were significantly lower in children diagnosed with FAP-NOS and we consider that this difference could be attributed to malabsorption secondary to dysbiosis as there is not enough data.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Although the exact pathophysiology of functional gastrointestinal diseases remains unclear, numerous etiologies have been blamed, including visceral hypersensitivity, gastrointestinal motility disorders, psychological factors, intestinal mucosal inflammation, intestinal microbiota, and post-infectious syndromes.
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Temel Bulgular & Veri:The study included a total of 110 patients aged 4-17 years who were diagnosed with FAP-NOS according to Rome IV criteria.
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Sonuç & Katkı:FE-1 levels were significantly lower in children diagnosed with FAP-NOS and we consider that this difference could be attributed to malabsorption secondary to dysbiosis as there is not enough data.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Background. Although the exact pathophysiology of functional gastrointestinal diseases remains unclear, numerous etiologies have been blamed, including visceral hypersensitivity, gastrointestinal motility disorders, psychological factors, intestinal mucosal inflammation, intestinal microbiota, and post-infectious syndromes. In the present study, we aimed to evaluate pancreatic insufficient patients diagnosed with functional abdominal pain-not otherwise specified (FAP-NOS) according to Rome IV criteria. Methods. The study included a total of 110 patients aged 4-17 years who were diagnosed with FAP-NOS according to Rome IV criteria. The control group consisted of 80 patients with no gastrointestinal disorders and chronic diseases. Glucose, amylase, lipase, pancreatic amylase, immunoreactive trypsinogen (IRT) and fecal elastase (FE-1) levels were examined for each patient. Results. No significant difference was found between the two groups with regard to lipase, pancreatic amylase, IRT, and serum glucose levels. However, the amylase levels were significantly higher and the FE-1 levels were significantly lower in the study group compared to the control group (p=0.007 and p<0.001). The cut-off value detected in in ROC analysis for the diagnostic value of FE-1 in predicting FAP-NOS was found to be 140.107 μg/g. Based on this value, the sensitivity, specificity, PPV, and NPV of FE-1 were 82.1%, 66.2%, 77%, 73%, respectively. Accordingly, the likelihood of FE-1 in providing a positive value in patients with FAP-NOS was almost 9 times higher than in individuals without FAP-NOS. Conclusions. FE-1 levels were significantly lower in children diagnosed with FAP-NOS and we consider that this difference could be attributed to malabsorption secondary to dysbiosis as there is not enough data.

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Bu Makaleye Atıf Yap

GÜVEN, B., TURAN, N. B., ÖNER, A. F., KARAMAN, K., ÇETİN, M. (2021). Fecal elastase levels in children diagnosed with functional abdominal pain-not otherwise specified. Turkish Journal of Pediatrics, Cilt: 63 - Sayı: 1, 102–108. https://ajindex.com/articles/411959

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Kaynakça (14)

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