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Dergiler / Turkish Journal of Obstetrics and Gynecology / 2022 / Cilt: 19 - Sayı: 1

Brucellosis in pregnancy and its response to the changing immunoglobulin A: A prospective controlled study

Gebelikte bruselloz ve değişen immünoglobülin A yanıtı: Prospektif kontrollü çalışma

Demet AYDOĞAN KIRMIZI
Emre BAŞER
Emine ŞÖLEN
Mustafa KARA
Melike DEMİR ÇALTEKİN
Neziha YILMAZ
Taylan ONAT
Ethem Serdar YALVAÇ
Sayfa
1–6
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The role of the altered IgA response in pathologies that are associated with Brucella infection stands out as a new target for disease pathophysiology

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: This study aimed to define the rare Brucella infection in pregnancy and its effects on immunoglobulins (Ig).
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Temel Bulgular & Veri:The study group consisted of pregnant women who were at 20 weeks or below gestation and applied to our hospital outpatient clinic for routine check-ups.
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Sonuç & Katkı:The role of the altered IgA response in pathologies that are associated with Brucella infection stands out as a new target for disease pathophysiology
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: This study aimed to define the rare Brucella infection in pregnancy and its effects on immunoglobulins (Ig). Materials and Methods: This prospective study has conducted Brucella screening using the Rose Bengal test on pregnant and non-pregnant outpatients who did not show any specific Brucella symptoms. The immunoglobulin levels were measured using the enzyme-linked immunosorbent assay. The study group consisted of pregnant women who were at 20 weeks or below gestation and applied to our hospital outpatient clinic for routine check-ups. The control group consisted of healthy patients who applied for routine controls. Results: This study included a total of 584 participants, 293 of whom were controls and 291 were the study (pregnant) participants. The study revealed a 1.5% incidence of Brucella during pregnancy. In acute and chronic Brucella infection, lower levels of IgA response were observed in pregnant cases compared to the control group. Conclusion: Brucella infection is a disease that can cause fetal problems, especially in endemic areas. The role of the altered IgA response in pathologies that are associated with Brucella infection stands out as a new target for disease pathophysiology

Abstract

Amaç: Bu çalışma, gebelikte nadir görülen Brusella enfeksiyonunu ve immünoglobulinler (Ig) üzerine etkilerini belirlemek amacıyla planlandı. Gereç ve Yöntemler: Bu çalışma prospektif olarak planlandı. Bu amaçla, hastanemiz polikliniğine başvuran 20. gebelik haftası ve altı gebeler spesifik Brusella semptomlarına bakılmaksızın Rose Bengal testi ile tarandı. İmmünoglobulin seviyeleri enzim bağlı immünosorbent deneyi ile ölçüldü. Kontrol grubu rutin kontroller için başvuran sağlıklı hastalardan oluşturuldu. Bulgular: Bu çalışmaya 293’ü kontrol ve 291’i çalışma (gebe) olmak üzere toplam 584 katılımcı dahil edilmiştir. Çalışmada gebelikte Brusella görülme sıklığı %1,5 olarak bulunmuştur. Akut ve kronik Brusella enfeksiyonunda gebe olgularda kontrol grubuna göre daha düşük seviyelerde IgA yanıtı gözlendi. Sonuç: Brusella enfeksiyonu özellikle endemik bölgelerde fetal problemlere neden olabilen bir hastalıktır. Brusella enfeksiyonu ile ilişkili patolojilerde değişen IgA yanıtının rolü, hastalığın patofizyolojisi için yeni bir hedef olarak öne çıkmaktadır

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Bu Makaleye Atıf Yap

KIRMIZI, D. A., BAŞER, E., ŞÖLEN, E., KARA, M., ÇALTEKİN, M. D., YILMAZ, N., ONAT, T., YALVAÇ, E. S. (2022). Brucellosis in pregnancy and its response to the changing immunoglobulin A: A prospective controlled study. Turkish Journal of Obstetrics and Gynecology, Cilt: 19 - Sayı: 1, 1–6. https://ajindex.com/articles/411642

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