Dergiler / Turkish Journal of Hematology / 2021 / Cilt: 38 - Sayı: 3

Association of Immune Thrombocytopenia and Celiac Disease in Children: A Retrospective Case Control Study

Çocuklarda İmmün Trombositopeni ve Çölyak Hastalık Birlikteliği: Retrospektif Olgu Kontrol Çalışması

Sayfa
175–180
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Furthermore, some patients may recover from ITP after starting a gluten-free diet.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: The association between celiac disease (CD) and immune thrombocytopenia (ITP) is still uncertain.
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Temel Bulgular & Veri:Materials and Methods: This is a retrospective multicenter study investigating the occurrence of CD in 28 children with ITP diagnosed from January 1, 2000, to December 31, 2019.Results: The first diagnosis was ITP in 57.1% and CD in 32.1% of patients.
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Sonuç & Katkı:Furthermore, some patients may recover from ITP after starting a gluten-free diet.
🔬Tür:Araştırma Makalesi
📍Kapsam:2000 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: The association between celiac disease (CD) and immune thrombocytopenia (ITP) is still uncertain. The aim of this study was to characterize the coexistence of these two diseases in Italian children. Materials and Methods: This is a retrospective multicenter study investigating the occurrence of CD in 28 children with ITP diagnosed from January 1, 2000, to December 31, 2019.Results: The first diagnosis was ITP in 57.1% and CD in 32.1% of patients. In 3 patients (10.7%), the two diagnoses were simultaneous. All the potential and silent cases of CD in our cohort were diagnosed in the groups of “ITP first” and “simultaneous diagnosis”. In all children ITP was mild, and in 2 out of 8 not recovered from ITP at the time of CD diagnosis a normalization of platelet counts (>100,000/μL) occurred 3 and 5 months after starting a gluten-free diet, respectively. Conclusion: We think that screening for CD should be considered in children with ITP regardless of the presence of gastrointestinal symptoms. Furthermore, some patients may recover from ITP after starting a gluten-free diet.

Abstract

Amaç: İmmün trombositopeni (İTP) ve çölyak hastalığı (ÇH) arasındaki ilişki hala belirsizliğini korumaktadır. Bu çalışmanın amacı İtalyan çocuklarında bu iki hastalık arasındaki ilişkiyi ortaya koymaktır. Gereç ve Yöntemler: Bu çalışma, 1 Ocak 2000’den 31 Aralık 2019’a kadar İTP tanısına ek olarak ÇH tanısı alan 28 çocuğun araştırıldığı geriye dönük çok merkezli bir çalışmadır.Bulgular: Hastaların %57,1’inde ilk tanı İTP ve %32,1’inde ÇH idi. Üç hastada (%10,7) iki tanı aynı anda konulmuştu. Kohortumuzdaki tüm potansiyel ve sessiz ÇH olguları “önce İTP” ve “eşzamanlı tanı” gruplarında teşhis edildi. Tüm çocuklarda İTP hafifti ve ÇH tanısı sırasında trombositopenisi devam eden 8 çocuktan 2’sinde, glutensiz diyete başladıktan sonra sırasıyla 3 ve 5 ayda trombosit sayılarında normalleşme (>100.000/μL) görüldü. Sonuç: Bu çalışma İTP’li çocuklarda gastrointestinal semptomların varlığına bakılmaksızın ÇH taramasının yapılması gerektiğini düşündürmektedir. Bazı hastalarda trombosit sayılarının glutensiz bir diyete başladıktan sonra düzelebileceği akılda bulundurulmalıdır

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Bu Makaleye Atıf Yap

GUARİNA, A., MARİNONİ, M., LASSANDRO, G., SARACCO, P., PERROTTA, S., FACCHİNİ, E., NOTARANGELO, L. D., RUSSO, G., GİORDANO, P., ROMANO, F., BERTONİ, E., GORİO, C., BOSCAROL, G., MOTTA, M., SPİNELLİ, M., BARONE, A., ZECCA, M., COMPAGNO, F., LA, S. (2021). Association of Immune Thrombocytopenia and Celiac Disease in Children: A Retrospective Case Control Study. Turkish Journal of Hematology, Cilt: 38 - Sayı: 3, 175–180. https://ajindex.com/articles/411551

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Kaynakça (13)

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