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Dergiler / Turkish Journal of Gastroenterology / 2016 / Cilt: 27 - Sayı: 1

Ovaries are more vulnerable than hepatocytes for insulin resistance and hyperinsulinemia

İLHAMİ GÜLTEPE
Metin BAŞARANOĞLU
Yaser SÜLEYMANOĞLU
Gökçen BAŞARANOĞLU
Fatma BEYAZIT
Sayfa
62–67
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: This study showed that rather than pancreatic beta-cell hyperfunction, insulin resistance plays a central role in the development of ovarian abnormalities

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background/Aims: Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are common metabolic disorders.
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Temel Bulgular & Veri:Materials and Methods: Thirty female patients with NAFLD and without PCOS; 12 female patients with PCOS; and a control group with 17 healthy females were included.
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Sonuç & Katkı:Conclusion: This study showed that rather than pancreatic beta-cell hyperfunction, insulin resistance plays a central role in the development of ovarian abnormalities
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Background/Aims: Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are common metabolic disorders. We aimed to evaluate the underlying mechanisms in the development of NAFLD and PCOS. Materials and Methods: Thirty female patients with NAFLD and without PCOS; 12 female patients with PCOS; and a control group with 17 healthy females were included. Pancreatic homeostatic model assessment-Beta cell function was measured by the homeostasis model assessment (HOMA)-B test.Results: The body mass index (BMI) of the NAFLD patients was higher than that of the PCOS patients (29.4±3.8 kg/m² vs 25.6±5.2 kg/m², p<0.05). There was no significant difference between the PCOS patients and controls with respect to BMI. The fasting insulin levels of the NAFLD patients were higher than those of the PCOS patients (5.06 unit more than PCOS, p<0.05) and 12.8 unit more than controls (p<0.001). The HOMA scores of the NAFLD patients were more than those of the PCOS patients (1.41 unit more than PCOS, p<0.05) and 2.95 unit more than controls (p<0.001). The HOMA-B score was higher in the NAFLD patients than in the PCOS patients. There was no statistical difference among the groups for serum triglyceride (p>.05) and cholesterol (p>.05). Conclusion: This study showed that rather than pancreatic beta-cell hyperfunction, insulin resistance plays a central role in the development of ovarian abnormalities

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Bu Makaleye Atıf Yap

GÜLTEPE, İ., BAŞARANOĞLU, M., SÜLEYMANOĞLU, Y., BAŞARANOĞLU, G., BEYAZIT, F. (2016). Ovaries are more vulnerable than hepatocytes for insulin resistance and hyperinsulinemia. Turkish Journal of Gastroenterology, Cilt: 27 - Sayı: 1, 62–67. https://ajindex.com/articles/410743

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Kaynakça (12)

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