Dergiler / Turkish Journal of Gastroenterology / 2017 / Cilt: 28 - Sayı: 6

Vildagliptin-induced acute pancreatitis without enzyme elevation

Sayfa
514–517
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In conclusion, even when serum amylase and lipase levels are normal, AP should be kept in mind when making a differential diagnosis of patients with diabetes mellitus who present with abdominal pain and take dipeptidyl peptidase-4 (DPP-4) inhibitors

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:We describe 2 patients with diabetes mellitus, presenting with upper abdominal pain.
📊
Temel Bulgular & Veri:Although imaging findings were consistent with acute pancreatitis (AP), serum amylase and lipase levels were within normal limits.
💡
Sonuç & Katkı:In conclusion, even when serum amylase and lipase levels are normal, AP should be kept in mind when making a differential diagnosis of patients with diabetes mellitus who present with abdominal pain and take dipeptidyl peptidase-4 (DPP-4) inhibitors
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

We describe 2 patients with diabetes mellitus, presenting with upper abdominal pain. Although imaging findings were consistent with acute pancreatitis (AP), serum amylase and lipase levels were within normal limits. In both the cases, the only identifiable diagnostic culprit was vildagliptin. This is the first reported case of vildagliptin causing AP clinically and radiographically without elevated serum pancreatic enzymes. In conclusion, even when serum amylase and lipase levels are normal, AP should be kept in mind when making a differential diagnosis of patients with diabetes mellitus who present with abdominal pain and take dipeptidyl peptidase-4 (DPP-4) inhibitors

🔖

Bu Makaleye Atıf Yap

MUNGAN, Z., ATTİLA, T., KABAOĞLU, Z. Ü., VURAL, M. (2017). Vildagliptin-induced acute pancreatitis without enzyme elevation. Turkish Journal of Gastroenterology, Cilt: 28 - Sayı: 6, 514–517. https://ajindex.com/articles/410715

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (10)

  1. Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis-2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013; 62: 102- 11
  2. Cartier T, Sogni P, Perruche F, et al. Normal lipase serum level in acute pancreatitis: a case report. Emerg Med J 2006; 23:701-2
  3. Shah AM, Eddi R, Kothari ST, Maksoud C, DiGiacomo S, Baddoura W. Acute pancreatitis with normal serum lipase: A case series. JOP 2010; 11: 369-72
  4. Rao EMM, Ganga V, Moore M, Medarametla S. A case of acute pancreatitis without enzyme elevation-A rare presentation of a common condition. Clin Med Rev Case Rep 2015; 2: 66
  5. Mathur AK, Whitaker A, Kolli H, Nguyen T. Acute pancreatitis with normal serum lipase and amylase: A rare presentation. JOP 2016; 17: 98-101
  6. US Food and Drug Administration. MedWatch 2009 Safety Alerts for Human products: Sitagliptin (marketed as Januvia and Janumet) - acute pancreatitis. September 25, 2009. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsHuman medicalProducts/ucm183800.htm
  7. Bekiari E, Rizava C, Athanasiadou E, et al. Systematic review and meta-analysis of vildagliptin for treatment of type 2 diabetes. Endocrine 2016: 52; 458-80
  8. Girgis CM, Champion BL. Vildagliptin-induced pancreatitis. Endocr Pract 2011; 17: 48-50
  9. Kunjathaya P, Ramaswami PK, Krishnamurthy AN, Bhat N. Acute necrotizing pancreatitis associated with Vildagliptin. JOP 2013: 14; 81-4
  10. Yadav D, Agarwal N, Pitchumoni Cs. A critical evaluation of laboratory tests in acute pancreatitis. Am J Gastroenterol 2002; 97: 1309-18.