Beneficial effect of synbiotics on experimental colon cancer in rats

The results of this experimentalstudy suggest that treatment with a synbiotic preparation exerts significant antimutagenic properties against the development ofpreneoplastic lesions in rats.

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Amaç & Hipotez:Background/Aims: The aim of this study was to investigate the influence of a synbiotic preparation (a mixture of six probiotics and aprebiotic) on aberrant crypt foci (ACF) formation, dysplasia, inflammation, and colitis-like lesions in experimental colon cancer in rats.Materials and Methods: Sixty male rats were categorized into three groups of 20 animals each.

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Temel Bulgular & Veri:Group A was administered1,2-dimethylydrazine, 15 mg/kg body weight (BW), once a week for 2 weeks.

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Sonuç & Katkı:The results of this experimentalstudy suggest that treatment with a synbiotic preparation exerts significant antimutagenic properties against the development ofpreneoplastic lesions in rats.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Özet

Background/Aims: The aim of this study was to investigate the influence of a synbiotic preparation (a mixture of six probiotics and aprebiotic) on aberrant crypt foci (ACF) formation, dysplasia, inflammation, and colitis-like lesions in experimental colon cancer in rats.Materials and Methods: Sixty male rats were categorized into three groups of 20 animals each. Group A was administered1,2-dimethylydrazine, 15 mg/kg body weight (BW), once a week for 2 weeks. Group B was administered 1,2-dimethylydrazine at thesame dose plus synbiotic, started after the second dose of carcinogen and lasted for 5 weeks. Group C was administered synbiotic pluscarcinogen from the beginning of the experiment and lasted for 7 weeks. Animals were killed at the end of week 7.Results: At the end of the experiment, the animals that received carcinogen plus the synbiotic had 100%, whereas the animals thatreceived only carcinogen has 70% survival. Animals of groups B and C had significantly lower percentage of inflammation, colitis-likelesions, and ACF dysplasia than animals of group A, whereas those of group C had the least pathological lesions.Conclusion: Synbiotics seem to protect against the appearance of preneoplastic colon lesions in rats. The results of this experimentalstudy suggest that treatment with a synbiotic preparation exerts significant antimutagenic properties against the development ofpreneoplastic lesions in rats.

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Bu Makaleye Atıf Yap

GAVRESEA, F., VAGIANOS, C., KORONTZI, M., SOTIROPOULOU, G., DADIOTI, P., TRIANTAFILLIDIS, J. K., PAPALOIS, A. E. (2018). Beneficial effect of synbiotics on experimental colon cancer in rats. Turkish Journal of Gastroenterology, Cilt: 29 - Sayı: 4, 494–501. https://ajindex.com/articles/410123

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