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Dergiler / International Journal of Medical Biochemistry / 2021 / Cilt: 4 - Sayı: 2

Apolipoprotein E and adiponectin levels in coronary artery disease patients with low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol discordance

Özge KURUMUŞ
Aycan FAHRİ ERKAN
Neslihan ÇOBAN
Ayşem KAYA
Evin ADEMOĞLU
Sayfa
85–90
DOI
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Conclusion: While discordance between the LDL-C and the non-HDL-C in CAD patients (14%) was observed, the plas ma ApoE and adiponectin levels were not significantly different between the discordant and concordant groups.

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Amaç & Hipotez:Objectives: The aim of this study was to investigate whether serum apolipoprotein E (ApoE) and adiponectin were as sociated with discordance of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) levels in coronary artery disease (CAD) patients.
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Temel Bulgular & Veri:Methods: A total of 243 patients with significant CAD were studied.
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Sonuç & Katkı:Conclusion: While discordance between the LDL-C and the non-HDL-C in CAD patients (14%) was observed, the plas ma ApoE and adiponectin levels were not significantly different between the discordant and concordant groups.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objectives: The aim of this study was to investigate whether serum apolipoprotein E (ApoE) and adiponectin were as sociated with discordance of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) levels in coronary artery disease (CAD) patients. Methods: A total of 243 patients with significant CAD were studied. The fasting levels of serum lipids, plasma ApoE, and adiponectin were measured. The median LDL-C and non-HDL-C values were determined to assess and analyze discordance. Discordance was defined as an LDL-C≥ the median and non-HDL-C< the median, or an LDL-C< the median and a non-HDL-C≥ the median. ApoE and adiponectin were compared between discordant and concordant groups. Results: Discordance between the LDL-C and the non-HDL-C was observed in 14% of the patients. Although the me dian adiponectin was lowest in the group with an LDL-C< median and a non-HDL-C≥ the median, and the median ApoE was lowest in the group with an LDL-C≥ median and a non-HDL-C< the median, no statistically significant differences in the ApoE and adiponectin were recorded between the groups (p=0.186 and p=0.161, respectively). Adiponectin was negatively correlated with triglyceride and remnant cholesterol (p<0.001 and p<0.001, respectively). Conclusion: While discordance between the LDL-C and the non-HDL-C in CAD patients (14%) was observed, the plas ma ApoE and adiponectin levels were not significantly different between the discordant and concordant groups.

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Bu Makaleye Atıf Yap

KURUMUŞ, Ö., ERKAN, A. F., ÇOBAN, N., KAYA, A., ADEMOĞLU, E. (2021). Apolipoprotein E and adiponectin levels in coronary artery disease patients with low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol discordance. International Journal of Medical Biochemistry, Cilt: 4 - Sayı: 2, 85–90. https://ajindex.com/articles/406973

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Kaynakça (12)

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