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Dergiler / International Journal of Medical Biochemistry / 2021 / Cilt: 4 - Sayı: 3

Examination of fasting and postprandial dynamic thiol disulfide homeostasis and oxidative stress

Ahmet Rıfat BALIK
Betül ÖZBEK İPTEÇ
Gülşen YILMAZ
Özcan EREL
Cemile BİÇER
Reyhan ERSOY
Sayfa
185–191
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Protein thiols involved in antioxidant defense were oxidized and transformed into disulfides.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objectives: Oxidative stress has a central role in metabolic disorders associated with high-carbohydrate, ani mal-based-protein diets, and excessive fat consumption.
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Temel Bulgular & Veri:Methods: A total of 86 participants (43 males and 43 females), were included in the study.
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Sonuç & Katkı:Protein thiols involved in antioxidant defense were oxidized and transformed into disulfides.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objectives: Oxidative stress has a central role in metabolic disorders associated with high-carbohydrate, ani mal-based-protein diets, and excessive fat consumption. However, the molecular mechanisms of nutrition-mediated oxidative stress are complex and not fully understood. Dynamic thiol-disulfide homeostasis (DTDH) is the regulation of a balance between thiols and their oxidized forms, and includes the reversal of thiol oxidation in proteins. This study was an evaluation of DTDH and postprandial oxidative stress. Methods: A total of 86 participants (43 males and 43 females), were included in the study. Fasting and non-fasting blood samples were collected and the native thiol, total thiol, and disulfide parameters were analyzed. Statistical anal yses were performed using IBM SPSS Statistics for Windows, Version 22.0 (IBM Corp., Armonk, NY, USA). Results: The findings indicated that while the native thiol values were significantly lower in the postprandial samples, the disulfide values were significantly higher. There was no significant difference in the total thiol values. Conclusion: Examination of the DTDH revealed that the oxidative stress level increased following food intake. Protein thiols involved in antioxidant defense were oxidized and transformed into disulfides.

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Bu Makaleye Atıf Yap

BALIK, A. R., İPTEÇ, B. Ö., YILMAZ, G., EREL, Ö., BİÇER, C., ERSOY, R. (2021). Examination of fasting and postprandial dynamic thiol disulfide homeostasis and oxidative stress. International Journal of Medical Biochemistry, Cilt: 4 - Sayı: 3, 185–191. https://ajindex.com/articles/406968

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Kaynakça (13)

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