Dergiler / Turkish Journal of Pharmaceutical Sciences / 2019 / Cilt: 16 - Sayı: 3

Evaluation of the Antidiabetic Activity of Alchemilla persica Rothm. in Mice with Diabetes Induced by Alloxan

Alloksanla İndüklenen Farelerde Alchemilla persica Rothm.’nın Antidiyabetik Etkisinin Değerlendirilmesi

Sayfa
261–264
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

However, the aerial parts notably increased bloodglucose levels at doses of 100 mg/kg and 200 mg/kg.Conclusion: A. persica usage as an antidiabetic is not confirmed in the present study.

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Amaç & Hipotez:Objectives: Alchemilla species are used in Turkish folk medicine for the treatment of many diseases together with diabetes.
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Temel Bulgular & Veri:Alchemilla persica,belonging to this genus, is widely distributed in Eastern Anatolia as well as in Caucasia, northern and northeastern Iran, and northern Iraq.Materials and Methods: Methanolic-water extracts of the aerial parts and roots of A. persica were evaluated for their hypoglycemic activities in micewith alloxan-induced diabetes in order to verify its usage in folk medicine.Results: None of the tested extracts exhibited a significant lowering effect on blood glucose levels.
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Sonuç & Katkı:However, the aerial parts notably increased bloodglucose levels at doses of 100 mg/kg and 200 mg/kg.Conclusion: A. persica usage as an antidiabetic is not confirmed in the present study.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objectives: Alchemilla species are used in Turkish folk medicine for the treatment of many diseases together with diabetes. Alchemilla persica,belonging to this genus, is widely distributed in Eastern Anatolia as well as in Caucasia, northern and northeastern Iran, and northern Iraq.Materials and Methods: Methanolic-water extracts of the aerial parts and roots of A. persica were evaluated for their hypoglycemic activities in micewith alloxan-induced diabetes in order to verify its usage in folk medicine.Results: None of the tested extracts exhibited a significant lowering effect on blood glucose levels. However, the aerial parts notably increased bloodglucose levels at doses of 100 mg/kg and 200 mg/kg.Conclusion: A. persica usage as an antidiabetic is not confirmed in the present study.

Abstract

Amaç: Alchemilla türleri Türk halk tıbbında diyabetin yanında birçok hastalığın da tedavisinde kullanılmaktadır. Bu cinse ait olan Alchemilla persica; Doğu Anadolu, Kafkasya, Kuzey ve Kuzeydoğu İran ile Kuzey Irak’ta yetişmektedir. Gereç ve Yöntemler: Bu çalışmada Alchemilla persica’nın halk arasındaki kullanımını doğrulamak amacıyla; toprak üstü kısım ve köklerinin sulumetanollü ekstrelerinin alloksan indüklü diyabetik fareler üzerindeki hipoglisemik etkileri test edilmiştir. Bulgular: Test edilen ekstrelerden hiçbiri kan glukoz düzeyini kayda değer biçimde düşürmezken, A. persica toprak üstü kısımları kan glukoz düzeyini 100 mg/kg ve 200 mg/kg dozlarda önemli ölçüde artırmıştır. Sonuç: Bu çalışma A. persica’nın antidiyabetik olarak kullanımını doğrulamamıştır.

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Bu Makaleye Atıf Yap

ÖZBİLGİN, S., ÖZBEK, H., KIRMIZI, N. İ., ÖZ, B. E., KURTUL, E., ÖZRENK, B. C., İŞCAN, G. S., ACIKARA, Ö. B. (2019). Evaluation of the Antidiabetic Activity of Alchemilla persica Rothm. in Mice with Diabetes Induced by Alloxan. Turkish Journal of Pharmaceutical Sciences, Cilt: 16 - Sayı: 3, 261–264. https://ajindex.com/articles/404073

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