Meme koruyucu cerrahi ve radyoterapi uygulanan hastalarda tedavi sonuçlarımız

Amaç & Hipotez:Bu çalışmada 1999-2002 yılları arasında meme koruyucu cerrahi ve radyoterapi uygulanan erken evre meme karsinomlu 85 hasta geriye dönük olarak incelenmiştir Hastaların 61'i premenapoze, 24'ü ise postmenapozedir.Cerrahi yöntem olarak 35 hastaya geniş lokal eksizyon, 34 hastaya kadranektomi ve 16 hastaya da tümerektomi uygulanmıştır.

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Temel Bulgular & Veri:Patolojik inceleme sonuçlarına göre 26 hasta evre I, 38 hasta evre IIA, 15 hasta evre IIB, 6 hasta ise evre IIIA'dır.Uygulanan cerrahi yöntemle 69 hastada negatif cerrahi sınır sağlanırken, 7 hastada cerrahi sınır yakın, 9 hastada ise pozitiftir.

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Sonuç & Katkı:Ortalama 24 ay olan takip süresince sadece 1 hastada lokal yineleme görülürken, 3 hasta da ise uzak metastaz saptanmıştır.

🔬Tür:Deneysel Tarla Denemesi

📍Kapsam:2002 · 85 hasta

⚙️Değişkenler:Radyoterapi · Meme neoplazmları · Geriyedönük çalışma

Özet

Bu çalışmada 1999-2002 yılları arasında meme koruyucu cerrahi ve radyoterapi uygulanan erken evre meme karsinomlu 85 hasta geriye dönük olarak incelenmiştir Hastaların 61'i premenapoze, 24'ü ise postmenapozedir.Cerrahi yöntem olarak 35 hastaya geniş lokal eksizyon, 34 hastaya kadranektomi ve 16 hastaya da tümerektomi uygulanmıştır. Patolojik inceleme sonuçlarına göre 26 hasta evre I, 38 hasta evre IIA, 15 hasta evre IIB, 6 hasta ise evre IIIA'dır.Uygulanan cerrahi yöntemle 69 hastada negatif cerrahi sınır sağlanırken, 7 hastada cerrahi sınır yakın, 9 hastada ise pozitiftir. Operasyon sonrası 34 hastaya 6 hafta içinde, 51 hastaya ise 6 hafta sonrasında radyoterapi uygulanmıştır. Kadranektomi uygulanan hastalarda tüm memeye postoperatif 50 Gy radyoterapi uygulanırken, geniş lokal eksizyon ve tümorektomi sonrası 10-16 Gy boost dozu eklenmiştir. Adjuvant kemoterapi 67 (%78.8) hastada, adjuvant hormonoterapi ise 51 (%60 ) hastada uygulanmıştır. Ortalama 24 ay olan takip süresince sadece 1 hastada lokal yineleme görülürken, 3 hasta da ise uzak metastaz saptanmıştır.

Abstract

Eighty-five patients with breast cancer who underwent conservative surgery and radiotherapy between 1999-2002 were invastigated retrospectively. Sixty-one patients were premenopausal, 24 patients were postmenopausal. Surgical method was wide local exicion in 35 patients, quadrantectomy in 34 patients and tumorectomy in 16 patients. In pathological staging 26 patients were stage I, 38 patients were stage IIA, 15 patients were stage IIB, 6 patients were stage IIIA. Surgical margin was negative in 69 patients, close in 7 patients and positive in 9 patients after surgical excision. Postperative radiotherapy was given in 6 weeks for 36 patients and given after 6 weeks for 51 patients. Radiotherapy dose was 50 Gy after quadrantectomy, 10-16 Gy boost dose was added after tumerectomy and wide local excision. Adjuvant chemotherapy was administered in 67 patients and adjuvant hormonotherapy was administered in 51 patients. Median follow-up time is 24 months. Local recurrence was seen in 1 patient and distant metastases were seen in 3 patients.

Anahtar kelimeler

Radyoterapi Meme neoplazmları Geriyedönük çalışma Mastektomi segmental Tedavi sonucu Radiotherapy Breast Neoplasms Retrospective Studies Mastectomy Segmental Treatment Outcome

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Bu Makaleye Atıf Yap

ERTAŞ, G., DURMUŞ, S., ALTUNDAĞ, M., ÜÇER, A. R., ABANUZ, H., ÇALIKOĞLU, T., ÖZBAĞI, K., DEMİRKASIMOĞLU, A., KAYA, B. (2004). Meme koruyucu cerrahi ve radyoterapi uygulanan hastalarda tedavi sonuçlarımız. Türk Hematoloji Onkoloji Dergisi, Cilt: 14 - Sayı: 3, 134–139. https://ajindex.com/articles/402091

Kaynakça (11)

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