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Dergiler / Uluslararası tarım araştırmalarında yenilikçi yaklaşımlar dergisi (Online) / 2021 / Cilt: 5 - Sayı: 3

Docking Studies on the Effects of Some Bioactive Compounds from Pistacia atlantica Desf. against Main Protease SARS-CoV2

Taıb NADJAT
Sıtayeb TAYEB
Necmi BEŞER
Aıssaouı NADİA
Sayfa
269–278
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Nevertheless, further investigations are required to develop and optimize drug process to combat SARS-CoV2.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Novel coronavirus which was named later as SARS-CoV2 appeared in Wuhan, China, in the end of December 2019.
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Temel Bulgular & Veri:Actually, no precise drugs are existed and research concerning SARS-CoV2 treatment is deficient.
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Sonuç & Katkı:Nevertheless, further investigations are required to develop and optimize drug process to combat SARS-CoV2.
🔬Tür:Araştırma Makalesi
📍Kapsam:2019 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Novel coronavirus which was named later as SARS-CoV2 appeared in Wuhan, China, in the end of December 2019. Actually, no precise drugs are existed and research concerning SARS-CoV2 treatment is deficient. SARS-CoV2 main protease (Mpro) was crystallized by Liu et al. (2020) and represented a crucial drug target. The present work aimed to evaluate some bioactive compounds from Pistacia atlantica as possible SARS-CoV2 Mpro inhibitors, based on molecular docking approach. Molecular docking was carried out using AutoDock Vina software. The results indicated that Beta-Eudesmol, Elemol, Verbenol, Pinocarvone, Myrtenal, Myrtenol and Trans-Carveol have a potential inhibitor activity of SARS-CoV2 Mpro. Nevertheless, further investigations are required to develop and optimize drug process to combat SARS-CoV2.

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Bu Makaleye Atıf Yap

NADJAT, T., TAYEB, S., BEŞER, N., NADİA, A. (2021). Docking Studies on the Effects of Some Bioactive Compounds from Pistacia atlantica Desf. against Main Protease SARS-CoV2. Uluslararası tarım araştırmalarında yenilikçi yaklaşımlar dergisi (Online), Cilt: 5 - Sayı: 3, 269–278. https://ajindex.com/articles/399844

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Kaynakça (9)

  1. Aanouz, I., Belhassan, A., El-Khatabi, K., Lakhlifi, K., El-ldrissi, M., & Bouachrine, M. 2020. Moroccan Medicinal plants as inhibitors against SARS-CoV-2 main protease: Computational investigations, Journal of Biomolecular Structure and Dynamics. Abdelli, I., Hassani, F., Bekkel Brikci, S., & Ghalem, S. 2020. In silico study the inhibition of Angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from western Algeria. Journal of Biomolecular Structure and Dynamics, (just-accepted), 1-7.
  2. Ait Said, S., Fernandez, C., Greff, S., Derridj, A., Gauquelin, T., & Mevy, J., 2011.Interpopulation variability of leaf morpho-anatomical and terpenoid patterns of Pistacia atlantica Desf. Ssp atlantica growng along an aridity gradient in Algeria. Flora-Morphology, Distribution, Functional Ecology of plants, 206(4), 397-405.
  3. Anand, K., Ziebuhr, J., Wadhwani, P., Mesters, J. R., & Hilgenfeld, R. 2003. (3CL pro) Structure: Basis for design of Anti-SARS drugs. Science, 300(5626), 1763–1767.
  4. Astani, A., Reichling, J., & Schnitzler, P. 2011. Screening for antiviral activities of isolated compounds from essential oils. Evidence-based complementary and alternative medicine. Benhammou, A., Yaacoubi, A., Nibou, L., & Tanouti, B. 2007. Chromium (VI) adsorption from aqueous solution onto Moroccan Al-pillared and cationic surfactant stevensite. Journal of hazardous materials, 140(1-2), 104-109.
  5. Benhammou, N., Bekkara, F. A., & Panovska, T. K. 2008. Antioxidant and antimicrobial activities of the Pistacia lentiscus and Pistacia atlantica extracts. African Journal of Pharmacy and Pharmacology, 2(2), 022-028.
  6. Benhassaini, H., Benabderrahmane, M., & Chikhi, K. 2003. Contribution à l'évaluation de l'activité antiseptique de l'oléorésine et des huiles essentielles du pistachier de l'Atlas sur certaines sources microbiennes: candida albicans (ATC 20027), candida albicans (ATCC 20032) et saccharomyces cerevisiae. Ethnopharmacologia, 30, 38-46.
  7. Berman H, Westbrook J, Feng Z, Gilliland G, Bhat T, Weissig H, Shindyalov I, Bourne P. 2000.
  8. The protein data bank. Bobone, S.; Hilsch, M.; Storm, J.; Dunsing, V.; Herrmann, A.; Chiantia, S. 2017. Phosphatidylserine Lateral Organization Influences the Interaction of Influenza Virus Matrix Protein 1 with Lipid Membranes. Boopathi, S., Poma, A. B., & Kolandaivel, P. 2020. Novel 2019
  9. Coronavirus Structure, Mechanism of Action, Antiviral drug promises and rule out against its treatment. Journal of Biomolecular St