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Dergiler / Türk Biyokimya Dergisi / 2021 / Cilt: 46 - Sayı: 5

Biological variation and reference change value data for serum copper, zinc and selenium in Turkish adult population

Ceylan BAL
Serpil ERDOĞAN
Gamze GÖK
Cemil NURAL
Betül ÖZBEK
Özcan EREL
Müjgan ERCAN
Muhittin A. SERDAR
Sayfa
587–592
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

We think that it would be more accurate to use RCV value for zinc and selenium in terms of following significant changes in recurrent results of a patient.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objectives: Calculation of biological variation (BV) com- ponents is very important in evaluating whether a test result is clinically significant.
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Temel Bulgular & Veri:Methods: A total of 10 serum samples were collected from each of the 15 healthy individuals (nine female, six male), once a week, during 10 weeks.
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Sonuç & Katkı:We think that it would be more accurate to use RCV value for zinc and selenium in terms of following significant changes in recurrent results of a patient.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objectives: Calculation of biological variation (BV) com- ponents is very important in evaluating whether a test result is clinically significant. The aim of this study is to analyze BV components for copper, zinc and selenium in a cohort of healthy Turkish participants. Methods: A total of 10 serum samples were collected from each of the 15 healthy individuals (nine female, six male), once a week, during 10 weeks. Copper, zinc and selenium levels were analyzed by atomic absorption spectrometer. BV parameters were calculated with the approach sug- gested by Fraser. Results: Analytical variation (CV A), within-subject BV (CV I ), between-subject BV (CV G) values were 8.4, 7.1 and 4.3 for copper; 4.2, 9.1 and 13.7 for zinc; 7.6, 2.5 and 6.9 for selenium, respectively. Reference change values (RCV) were 30.46, 27.56 and 22.16% for copper, zinc and sele- nium, respectively. The index of individuality (II) values were 1.65, 0.66 and 0.36 for copper, zinc and selenium, respectively. Conclusions: According to the results of this study, tradi- tional reference intervals can be used for copper but we do not recommend using it for zinc and selenium. We think that it would be more accurate to use RCV value for zinc and selenium in terms of following significant changes in recurrent results of a patient.

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Bu Makaleye Atıf Yap

BAL, C., ERDOĞAN, S., GÖK, G., NURAL, C., ÖZBEK, B., EREL, Ö., ERCAN, M., SERDAR, M. A. (2021). Biological variation and reference change value data for serum copper, zinc and selenium in Turkish adult population. Türk Biyokimya Dergisi, Cilt: 46 - Sayı: 5, 587–592. https://ajindex.com/articles/399038

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