It indicates that cytogenetic and Y-chromosome microdeletion studies should be conducted in cases with primary male infertility prior to selecting assisted reproductive techniques.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:Objective: The aim of this study was to determine the frequencies of chromosomal abnormalities and Y-chromosome microdeletions in Turkish cases with primary male infertility in a single center.Material and methods: Chromosomal abnormalities and Y-chromosome microdeletions were investigated in 1696 cases with primary male infertility between 2012 and 2017.
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Temel Bulgular & Veri:Karyotype analyzes and Y-chromosome microdeletions analyzes [azoospermia factor (AZF) regions] were performed in all cases by using standard cytogenetic methods and the multiplex polymerase chain reaction method, respectively.Results: Chromosomal abnormalities were found in 142 cases (8.4%; 142/1696).
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Sonuç & Katkı:It indicates that cytogenetic and Y-chromosome microdeletion studies should be conducted in cases with primary male infertility prior to selecting assisted reproductive techniques.
🔬Tür:Araştırma Makalesi
📍Kapsam:2012 Verileri
⚙️Değişkenler:Alan Parametreleri
Özet
Objective: The aim of this study was to determine the frequencies of chromosomal abnormalities and Y-chromosome microdeletions in Turkish cases with primary male infertility in a single center.Material and methods: Chromosomal abnormalities and Y-chromosome microdeletions were investigated in 1696 cases with primary male infertility between 2012 and 2017. Karyotype analyzes and Y-chromosome microdeletions analyzes [azoospermia factor (AZF) regions] were performed in all cases by using standard cytogenetic methods and the multiplex polymerase chain reaction method, respectively.Results: Chromosomal abnormalities were found in 142 cases (8.4%; 142/1696). Y-chromosome microdele-tions were detected in 46 cases (2.7%; 46/1696). Y-chromosome microdeletions in the AZFc region were found in 20 of 46 cases (43%).Conclusion: This study is one of the few were a large number of cases was studied in Turkey. It indicates that cytogenetic and Y-chromosome microdeletion studies should be conducted in cases with primary male infertility prior to selecting assisted reproductive techniques.
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Bu Makaleye Atıf Yap
ÖZDEMİR, T. R., ÖZYILMAZ, B., KAYA, Ö. Ö., KIRBIYIK, Ö., KOÇ, A., KUTBAY, Y. B., ERDOĞAN, K. M., GÜVENÇ, M. S., ÇAKMAK, Ö., KESKİN, M. Z., KÖSE, C., ZEYREK, T. (2020). Evaluation of chromosomal abnormalities and Y-chromosome microdeletions in 1696 Turkish cases with primary male infertility: A single-center study. Turkish Journal of Urology, Cilt: 46 - Sayı: 2, 95–100. https://ajindex.com/articles/379801
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