Dergiler / Turkish Journal of Obstetrics and Gynecology / 2018 / Cilt: 15 - Sayı: 1

The impact of different 75 g oral glucose tolerance test target ranges within normal limits on neonatal outcomes: A validation study

Normal sınırlardaki farklı 75 gr oral glukoz tolerans test hedef aralıklarının neonatal sonuçlar üzerine etkisi: Bir geçerlilik çalışması

Sayfa
8–11
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

However, because there are still adverse neonatal outcomes in womenwith OGTT results below the current thresholds and the number of SGA fetuses is higher in the glucose range 120-140 mg/dL of the first hour, the validityof the 75 g OGTT thresholds still needs further investigation

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objective: To investigate the impact of different 75 g glucose tolerance test (OGTT) target ranges within normal limits on neonatal outcomes, thus toinvestigate the validity of 75 g OGTT thresholds.Materials and Methods: The normal 1-hour and 2-hour ranges of 75 g OGTT levels of 110 pregnant women with no gestational diabetes mellitus (GDM)were further divided into three different sub-groups; for the 1 hour as group 1 ( 140 mg/dL) and forthe 2 hour as group 1 ( 135 mg/dL).
📊
Temel Bulgular & Veri:Results: For the 1-hour results, there was no statistically significant difference between groups in terms of age, body mass index, multiparity, neonatal hypoglycemia,hyperbilirubinemia, neonatal intensive care unit admission, birth weight, and LGT rates; however, the rate of small-for-gestational-age (SGA) infantswas significantly higher in group 2 compared with those in group 3.
💡
Sonuç & Katkı:However, because there are still adverse neonatal outcomes in womenwith OGTT results below the current thresholds and the number of SGA fetuses is higher in the glucose range 120-140 mg/dL of the first hour, the validityof the 75 g OGTT thresholds still needs further investigation
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: To investigate the impact of different 75 g glucose tolerance test (OGTT) target ranges within normal limits on neonatal outcomes, thus toinvestigate the validity of 75 g OGTT thresholds.Materials and Methods: The normal 1-hour and 2-hour ranges of 75 g OGTT levels of 110 pregnant women with no gestational diabetes mellitus (GDM)were further divided into three different sub-groups; for the 1 hour as group 1 ( 140 mg/dL) and forthe 2 hour as group 1 ( 135 mg/dL). Results: For the 1-hour results, there was no statistically significant difference between groups in terms of age, body mass index, multiparity, neonatal hypoglycemia,hyperbilirubinemia, neonatal intensive care unit admission, birth weight, and LGT rates; however, the rate of small-for-gestational-age (SGA) infantswas significantly higher in group 2 compared with those in group 3. For the 2-hour results, statistically similar results were found between the groups.Conclusion: A 2-hour 75 g OGTT has reliable threshold values for GDM screening. However, because there are still adverse neonatal outcomes in womenwith OGTT results below the current thresholds and the number of SGA fetuses is higher in the glucose range 120-140 mg/dL of the first hour, the validityof the 75 g OGTT thresholds still needs further investigation

Abstract

Amaç: Bu çalışma normal sınırlardaki farklı 75 gr oral glukoz tolerans test (OGTT) hedef aralıklarının yenidoğan sonuçlarına etkisini araştırarak 75 gr OGTT eşik değerlerinin geçerliliğini araştırmak için yapıldı. Gereç ve Yöntemler: Gestasyonel diabetes mellitus (GDM) saptanmayan 110 gebe kadınının normal sınırlardaki 1. saat ve 2. saat 75 gr OGTT değerleri 1. saat için grup 1 ( 140 mg/dL) olarak ve 2. saat için grup 1 ( 135 mg/dL) olarak üç alt gruba ayrıldı. Bulgular: Birinci saat sonuçlarda yaş, vücut kitle indeksi, multiparite, yenidoğan hipoglisemi, hiperbilirubinemi, yenidoğan yoğun bakım ünitesi ihtiyacı, doğum ağırlığı ve LGT oranları açısından gruplar arasında istatistiksel olarak anlamlı bir fark yoktu; bununla birlikte, grup 2’deki gebelik yaşı için küçük (SGA) bebeklerin oranı grup 3’e göre istatistiksel olarak anlamlı derecede yüksekti. İkinci saat sonuçlar gruplar arasında istatistiksel olarak benzer bulundu. Sonuç: İki saatlik 75 gr OGTT, GDM taraması için güvenilir eşik değerlerine sahiptir. Bununla birlikte, mevcut eşik OGTT değerleri altında olan kadınlarda olumsuz yenidoğan sonuçlar olması ve birinci saat 120-140 mg/dL glukoz aralığında SGA fetüs sayısının yüksek olması nedeniyle 75 gr OGTT eşik değerlerinin geçerliliği hala araştırmayı gerektirmektedir

🔖

Bu Makaleye Atıf Yap

SUBAŞI, S., İLHAN, G. A., PİRİMOĞLU, Z. M. (2018). The impact of different 75 g oral glucose tolerance test target ranges within normal limits on neonatal outcomes: A validation study. Turkish Journal of Obstetrics and Gynecology, Cilt: 15 - Sayı: 1, 8–11. https://ajindex.com/articles/376280

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (4)

  1. Alwan N, Tuffnell DJ, West J. Treatments for gestational diabetes. The Cochrane Database of Systematic Reviews 2009;(3):CD003395. Black MH, Sacks DA, Xiang AH, Lawrence JM. Clinical outcomes of pregnancies complicated by mild gestational diabetes mellitus differ by combinations of abnormal oral glucose tolerance test values. Diabetes Care 2010;33:2524-30. HAPO Study Cooperative Research Group, Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, Coustan DR, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008;358:1991-2002. American Diabetes Association (ADA). Diagnosis and classification of diabetes mellitus. Diabetes Care 2011;34 Suppl 1:S62-9. Metzger BE, Gabbe SG, Persson B, Buchanan TA, Catalano PA, Damm P, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy.International Association of Diabetes and Pregnancy Study Groups Consensus Panel. Diabetes Care 2010;33:676-82. Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy: a World Health Organization Guideline. World Health Organization (WHO). Diabetes Res Clin Pract 2014;103:341-63. American Diabetes Association (ADA). Classification and Diagnosis of Diabetes. Diabetes Care 2016;39 Suppl 1:S13-22. National Institute for Health and Care Excellence (NICE). Diabetes in pregnancy: management of diabetes and its complications from preconception to the postnatal period. Clinical guideline NG3.2015. Available from www.nice.org.uk/ guidance/ ng3/ resources/ diabetesin-pregnancy-management-of-diabetes-and-its-complications-frompreconception-to-the-postnatal-period-51038446021. Ovesen PG, Jensen DM, Damm P, Rasmussen S, Kesmodel US. Maternal and neonatal outcomes in pregnancies complicated by gestational diabetes. a nation-wide study. J Matern Fetal Neonatal Med 2015;28:1720-4.
  2. Laafira A, White SW, Griffin CJ, Graham D. Impact of the new IADPSG gestational diabetes diagnostic criteria on pregnancy outcomes in Western Australia. Aust N Z J Obstet Gynaecol 2016;56:36-41.
  3. Martino J, Sebert S, Segura MT, García-Valdés L, Florido J, Padilla MC, et al. Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes. J Clin Endocrinol Metab 2016;101:59-68.
  4. Peixoto AB, Caldas TM, Santos RO, Lopes KS, Martins WP, Araujo Júnior E. The impact of gestational diabetes and hypothyroidism on the third-trimester ultrasound parameters a