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Dergiler / Turkish journal of vascular surgery / 2019 / Cilt: 28 - Sayı: 3

Effects of mesenchymal stem cells to prevent adhesions for vascular reoperations: An experimental study

MEHMET KABALCI
Mehmet ZENGİN
Nuray BAYAR MULUK
ÜÇLER KISA
Sayfa
180–185
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Macroscopic scoring of adhesion andhistopathological scoring of tissue repair response were evaluated.Results: Macroscopic view of the adhesion values (Padjusted <0.0175), histopathological evaluation values (histiocytic response,vascularization, and granulocytic response and total response) (Padjusted <0.0175), and collagen deposit values (Padjusted <0.0175) of Group3 were significantly lower than Group 2.Conclusion: Our study results suggest that the use of MSCs seems to be useful to prevent adhesion formation in cutaneous injuries andthat MSCs promote wound healing without adhesions in the experimental setting.

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Amaç & Hipotez:Objectives: In the present study, we aimed to investigate whether mesenchymal stem cells (MSCs) were useful to reduce cutaneousadhesions, particularly for vascular reoperations.Materials and methods: In this experimental study, 12 adult male Wistar Albino rats were used.
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Temel Bulgular & Veri:In Group 1 (n=2, negative controlgroup), no incision was performed.
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Sonuç & Katkı:Macroscopic scoring of adhesion andhistopathological scoring of tissue repair response were evaluated.Results: Macroscopic view of the adhesion values (Padjusted <0.0175), histopathological evaluation values (histiocytic response,vascularization, and granulocytic response and total response) (Padjusted <0.0175), and collagen deposit values (Padjusted <0.0175) of Group3 were significantly lower than Group 2.Conclusion: Our study results suggest that the use of MSCs seems to be useful to prevent adhesion formation in cutaneous injuries andthat MSCs promote wound healing without adhesions in the experimental setting.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objectives: In the present study, we aimed to investigate whether mesenchymal stem cells (MSCs) were useful to reduce cutaneousadhesions, particularly for vascular reoperations.Materials and methods: In this experimental study, 12 adult male Wistar Albino rats were used. In Group 1 (n=2, negative controlgroup), no incision was performed. In Group 2 (n=5, positive control group), skin and subcutaneous tissues were incised. In Group 3(n=5, MSC group), skin and subcutaneous tissues were incised and 3×106 MSCs were applied. Macroscopic scoring of adhesion andhistopathological scoring of tissue repair response were evaluated.Results: Macroscopic view of the adhesion values (Padjusted <0.0175), histopathological evaluation values (histiocytic response,vascularization, and granulocytic response and total response) (Padjusted <0.0175), and collagen deposit values (Padjusted <0.0175) of Group3 were significantly lower than Group 2.Conclusion: Our study results suggest that the use of MSCs seems to be useful to prevent adhesion formation in cutaneous injuries andthat MSCs promote wound healing without adhesions in the experimental setting.

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Bu Makaleye Atıf Yap

KABALCI, M., ZENGİN, M., MULUK, N. B., KISA, Ü. (2019). Effects of mesenchymal stem cells to prevent adhesions for vascular reoperations: An experimental study. Turkish journal of vascular surgery, Cilt: 28 - Sayı: 3, 180–185. https://ajindex.com/articles/375776

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Kaynakça (11)

  1. Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL. Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg 2001;18:260-73.
  2. Roselli EE, Pettersson GB, Blackstone EH, Brizzio ME, Houghtaling PL, Hauck R, et al. Adverse events during reoperative cardiac surgery: frequency, characterization, and rescue. J Thorac Cardiovasc Surg 2008;135:316-23.
  3. Park CB, Suri RM, Burkhart HM, Greason KL, Dearani JA, Schaff HV, et al. Identifying patients at particular risk of injury during repeat sternotomy: analysis of 2555 cardiac reoperations. J Thorac Cardiovasc Surg 2010;140:1028-35.
  4. Shahian DM, O’Brien SM, Filardo G, Ferraris VA, Haan CK, Rich JB, et al. The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 1--coronary artery bypass grafting surgery. Ann Thorac Surg 2009;88:2-22. Sabik JF 3rd, Blackstone EH, Gillinov AM, Banbury MK, Smedira NG, Lytle BW. Influence of patient characteristics and arterial grafts on freedom from coronary reoperation. J Thorac Cardiovasc Surg 2006;131:90-8.
  5. Zapolanski A, Fishman NH, Bronstein MN, Ellertson DG, O’Connell TJ, Siegel S. Modified pericardial closure to protect cardiovascular structures during sternal reentry. Ann Thorac Surg 1990;50:665-6.
  6. Sayek İ, Ozmen MM. Temel Cerrahi El Kitabı. Ankara: Güneş Tıp Kitabevleri: 2009. Brunicardi CF. Schwartz’s Principles of Surgery. New York: Mc Graw-Hill; 2005. Ergin DN. Farklı Dikiş Materyallerinin Gingivada Oluşturduğu Doku Reaksiyonunun Değerlendirilmesi (Doktora Tezi). Ankara: Başkent Univeritesi; 2009).
  7. Jeffcoate WJ, Price P, Harding KG; International Working Group on Wound Healing and Treatments for People with Diabetic Foot Ulcers. Wound healing and treatments for people with diabetic foot ulcers. Diabetes Metab Res Rev 2004;20:78-89.
  8. Li J, Ezzelarab MB, Cooper DK. Do mesenchymal stem cells function across species barriers? Relevance for xenotransplantation. Xenotransplantation 2012;19:273-85.
  9. Karaca G, Pehlivanli F, Aydin O, Altunkaya C, Uzun H, Niyaz M, et al. The effect of mesenchymal stem cell use on intra-abdominal adhesions in a rat model. Ann Surg Treat Res 2018;94:57-62.
  10. Niyaz M, Gurpınar OA, Gunaydın S, Fu SC, Lee YW, Chan KM. Isolation, culturing and characterization of rat adipose tissuederived mesenchymal stem cells: a simple technique. Turk J Biol 2012;36:658-64
  11. Amini-Nik S, Cambridge E, Yu W, Guo A, Whetstone H, Nadesan P, et al. Beta-Catenin-regulated myeloid cell adhesion and