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Dergiler / Turkish Journal of Cancer / 2001 / Cilt: 31 - Sayı: 3

Pharmacokinetics of amikacin in febrile neutropenic pediatric patients with acute lymphoblastic leukemia

Nadeem İrfan BUKHARI
Samia YOUSUF
Muhammad JAMSHAID
Mazhar MUSTAFA
Sayfa
114–120
DOI
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Pharmacokinetics of amikacin in febrile neutropenic pediatric patients with acute lymphoblastic leukemia

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Pharmacokinetics of amikacin in febrile neutropenic pediatric patients with acute lymphoblastic leukemia
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Temel Bulgular & Veri:Pharmacokinetics of amikacin in febrile neutropenic pediatric patients with acute lymphoblastic leukemia
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Sonuç & Katkı:Pharmacokinetics of amikacin in febrile neutropenic pediatric patients with acute lymphoblastic leukemia
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:İlaç tedavisi · Pediatri · Amikasin

Özet

Pharmacokinetics of amikacin in febrile neutropenic pediatric patients with acute lymphoblastic leukemia

Abstract

The pharmacokinetics of amikacin was investigated in six oncohematologic pediatric patients who experienced neutropenia (<1,000/mm3) and fever (>38°C) induced by cancer chemotherapy. The concentration of amikacin in serum was determined by fluorescence polarization immunoassay method using Abbott TDx system. Pharmacokinetic parameters were estimated with the help of computer software, PK II. Peak serum concentration of 36.30±4.03 ug/ml was observed. The values for AUCo, AUMCo, and MRT were concluded to be 76.20$\pm$6.30 ug.hr/ml, 190.26±31.61 $\mu$g.hr2/ml and 2.15$\pm$0.62 hrs, respectively. The t1/2$\alpha$, t1/2elim, Cl and Vd were 0.0410.02 hr, 1.76$\pm$0.55 hr, 18.85$\pm$5.11 ml/min and 0.191$\pm$0.11 l/kg, respectively. When the present values were compared with the literature-cited values in normal as well as in diseased populations, some similarities and differences were observed. Due to polemical values reported for normal population the modifications in amikacin pharmacokinetics in pediatric cancer patients has left inconclusive. Further appraisal is required to make a firm conclusion.

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Bu Makaleye Atıf Yap

BUKHARI, N. İ., YOUSUF, S., JAMSHAID, M., MUSTAFA, M. (2001). Pharmacokinetics of amikacin in febrile neutropenic pediatric patients with acute lymphoblastic leukemia. Turkish Journal of Cancer, Cilt: 31 - Sayı: 3, 114–120. https://ajindex.com/articles/368384

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Kaynakça (17)

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