Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightFor preventing rapid progression, determination of factors that have aneffect on prognosis, in particular, is extremely important.
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Özet
Objective: The aim of this study was to evaluate children with pulmonary arterial hypertension (PAH) regarding epidemiological characteristics,clinical status with respect to the WHO functional class (WHO-FC), prognostic factors, and efficacy of medical treatment.Methods: A retrospective evaluation of 41 patients with PAH was made in the Pediatric Cardiology Unit, Gazi University Medical Faculty, betweenFebruary 2006 and October 2015.Results: Of the 41 patients included in this study, 51.2% were female. The median age was 60 months at first evaluation. The median follow-upwas 60 months. At the start of the treatment, 43.9% patients were receiving combined drug therapy, and this rate increased to 60.9% by the lastevaluation. The median time of adding a new medication to the therapy was 20 months. The 1- and 5-year survival rates were 94% and 86%,respectively. At the time of diagnosis, only pro-brain natriuretic peptide (proBNP) levels were associated with mortality (p=0.004), but at thelast evaluation, 6-min walking test, proBNP and uric acid levels, and WHO-FC were also associated with survival (p=0.02, p=0.001, p=0.002, andp=0.05, respectively).Conclusion: With current treatment choices in experienced centers, positive results are obtained with respect to the functional status andsurvival rates of patients with PAH. At the time of diagnosis, only proBNP had a prognostic value, whereas at the last evaluation, WHO-FC, 6-minwalking test, proBNP, and uric acid were reported prognostic factors. For preventing rapid progression, determination of factors that have aneffect on prognosis, in particular, is extremely important.