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Dergiler / The Anatolian Journal of Cardiology / 2016 / Cilt: 16 - Sayı: 3

Association of rs17042171 with chromosome 4q25 with atrial fibrillation in Chinese Han populations

Liyan ZHAO
Xin Guang CHEN
Yaowu LIU
Zhen FANG
Fengxiang ZHANG
Sayfa
165–169
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In the stratification analysis based on age, gender, hypertension, diabetes and coronary artery disease, there was no significant difference of the associations for rs17042171 among the subgroups.Conclusion: Our results indicated that rs17042171 confers an increased risk of AF in Chinese Han Populations and expanded the association to non-European ancestry populations for the first time

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: A recent genome-wide association study (GWAS) identified a susceptibility single nucleotide polymorphism (SNP), rs17042171 on 4q25 for atrial fibrillation (AF).
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Temel Bulgular & Veri:The aim of the present study was to investigate whether this association between rs17042171 and AF also exists in Chinese Han populations.Methods: It was a case-control study.
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Sonuç & Katkı:In the stratification analysis based on age, gender, hypertension, diabetes and coronary artery disease, there was no significant difference of the associations for rs17042171 among the subgroups.Conclusion: Our results indicated that rs17042171 confers an increased risk of AF in Chinese Han Populations and expanded the association to non-European ancestry populations for the first time
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: A recent genome-wide association study (GWAS) identified a susceptibility single nucleotide polymorphism (SNP), rs17042171 on 4q25 for atrial fibrillation (AF). The aim of the present study was to investigate whether this association between rs17042171 and AF also exists in Chinese Han populations.Methods: It was a case-control study. We enrolled a total of 1,593 Chinese Han origin individuals in the study, including 597 AF patients and 996 AF-free controls. Genotyping was performed using the TaqMan allelic discrimination Assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models.Results: There was strongly significant difference between AF patients and control subjects regarding rs17042171 assumption of additive model , dominant model and a recessive . In the stratification analysis based on age, gender, hypertension, diabetes and coronary artery disease, there was no significant difference of the associations for rs17042171 among the subgroups.Conclusion: Our results indicated that rs17042171 confers an increased risk of AF in Chinese Han Populations and expanded the association to non-European ancestry populations for the first time

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Bu Makaleye Atıf Yap

ZHAO, L., CHEN, X. G., LIU, Y., FANG, Z., ZHANG, F. (2016). Association of rs17042171 with chromosome 4q25 with atrial fibrillation in Chinese Han populations. The Anatolian Journal of Cardiology, Cilt: 16 - Sayı: 3, 165–169. https://ajindex.com/articles/365444

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Kaynakça (13)

  1. Kannel WB, Abbott RD, Savage DD, McNamara PM. Epidemiologic features of chronic atrial fibrillation: The Framingham study. N Engl J Med 1982; 306: 1018-22
  2. Benjamin EJ, Wolf PA, D'Agostino RB, Silbershatz H, Kannel WB, Levy D. Impact of atrial fibrillation on the risk of death: The Framingham heart study. Circulation 1998; 98: 946-52
  3. Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, et al. Prevalence of diagnosed atrial fibrillation in adults: National impli-cations for rhythm management and stroke prevention: The antico-agulation and risk factors in atrial fibrillation (ATRIA) study. JAMA 2001; 285: 2370-5
  4. Stewart S, Hart CL, Hole DJ, McMurray JJ. A population-based study of the long-term risks associated with atrial fibrillation: 20-year follow-up of the Renfrew/Paisley study. Am J Med 2002; 113: 359-64
  5. Schotten U, Verheule S, Kirchhof P, Goette A. Pathophysiological mechanisms of atrial fibrillation: A translational appraisal. Physiol Rev 2011; 91: 265-325
  6. Tsai CT, Lai LP, Hwang JJ, Lin JL, Chiang FT. Molecular genetics of atrial fibrillation. J Am Coll Cardiol 2008; 52: 241-50
  7. Marcus GM, Smith LM, Vittinghoff E, Tseng ZH, Badhwar N, Lee BK, et al. A first-degree family history in lone atrial fibrillation patients. Heart Rhythm 2008; 5: 826-30
  8. Fox CS, Parise H, D'Agostino RB Sr, Lloyd-Jones DM, Vasan RS, Wang TJ, et al. Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. JAMA 2004; 291: 2851-5
  9. Arnar DO, Thorvaldsson S, Manolio TA, Thorgeirsson G, Kristjansson K, Hakonarson H, et al. Familial aggregation of atrial fibrillation in Iceland. Eur Heart J 2006; 27: 708-12
  10. Gudbjartsson DF, Arnar DO, Helgadottir A, Gretarsdottir S, Holm H, Sigurdsson A, et al. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature 2007; 448: 353-7
  11. Kaab S, Darbar D, van Noord C, Dupuis J, Pfeufer A, Newton-Cheh C, et al. Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation. Eur Heart J 2009; 30: 813-9
  12. Shi L, Li C, Wang C, Xia Y, Wu G, Wang F, et al. Assessment of asso-ciation of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese han population. Hum Genet 2009; 126: 843-9
  13. Lee KT, Yeh HY, Tung CP, Chu CS, Cheng KH, Tsai WC, et al. Association of rs2200733 but not rs10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese popula-tion. Cardiology 20