KaydedilenlerDerginizi ekleyin

Dergiler / Şişli Etfal Hastanesi Tıp Bülteni / 2018 / Cilt: 52 - Sayı: 3

Evaluation of Toll-Like Receptor Expression with Clinicopathologic Variables in Endometrium Cancer

Berat Berrin GENÇOĞLU BAKBAK
Tolgay Tuyan İLHAN
Aybike PEKİN
ÖZLEM SEÇİLMİŞ KERİMOĞLU
Setenay Arzu YILMAZ
Ayşegül KEBAPCILAR
NASUH UTKU DOĞAN
Pınar KARABAĞLI
Çetin ÇELİK
Sayfa
194–196
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Inaddition, the presence of TLR 6 may indicate the presence of late-stage endometrial cancer.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objectives: Clinical evidence supports the association of toll-like receptor (TLR) with abnormal cell proliferation and cancer.
📊
Temel Bulgular & Veri:In thisstudy, we investigated the expression of TLRs 2, 4, 5, and 6 in healthy endometrium and endometrium cancer to study the relationshipof these receptors’ expression with carcinogenesis.Methods: Patients who had undergone a hysterectomy owing to endometrium cancer (group 1, 66 patients), endometrial hyperplasia(group 2, 14 patients), and other reasons besides endometrium cancer (group 3, 20 patients as controls) were included.The cases in the first group were classified by histological type of the cancer, stage, grade, and size of the tumor.
💡
Sonuç & Katkı:Inaddition, the presence of TLR 6 may indicate the presence of late-stage endometrial cancer.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objectives: Clinical evidence supports the association of toll-like receptor (TLR) with abnormal cell proliferation and cancer. In thisstudy, we investigated the expression of TLRs 2, 4, 5, and 6 in healthy endometrium and endometrium cancer to study the relationshipof these receptors’ expression with carcinogenesis.Methods: Patients who had undergone a hysterectomy owing to endometrium cancer (group 1, 66 patients), endometrial hyperplasia(group 2, 14 patients), and other reasons besides endometrium cancer (group 3, 20 patients as controls) were included.The cases in the first group were classified by histological type of the cancer, stage, grade, and size of the tumor. In all the cases,expressions of TLRs 2, 4, 5, and 6 were assessed, and the relationship of these receptors with clinicopathologic signs was analyzed.For immunohistochemical staining, nuclear and cytoplasmic stainings were considered positive. A Chi-squared test was used toassess the correlation of the groups. A p<0.05 was considered significant.Results: The mean ages of patients in groups 1, 2, and 3 were 59.8 (range 33–83), 48.3 (range 40–59), and 53.4 (range 38–84) years,respectively. All types of TLRs were highly expressed in both types of endometrium cancer (groups 1 and 2). TLR expression wasobserved with a ratio of 87.9% in group 1, 100% in group 2, and 35% in group 3. There was a statistically significant association ofTLR 2 among the three groups (p=0.000). TLR 6 expression in both group 1 and group 2 was significantly higher than that in thecontrol group (p=0.000, p=0.000, respectively). In addition, TLR 6 was higher in cases with late-stage cancer (p=0.033). Regardingtumor grade and the size of the tumor, no association was found between TLR 2 and TLR 6.Conclusion: TLR 2 and TLR 6 were significantly more expressed in cases with endometrium cancer and endometrial hyperplasia. Inaddition, the presence of TLR 6 may indicate the presence of late-stage endometrial cancer.

🔖

Bu Makaleye Atıf Yap

BAKBAK, B. B. G., İLHAN, T. T., PEKİN, A., KERİMOĞLU, Ö. S., YILMAZ, S. A., KEBAPCILAR, A., DOĞAN, N. U., KARABAĞLI, P., ÇELİK, Ç. (2018). Evaluation of Toll-Like Receptor Expression with Clinicopathologic Variables in Endometrium Cancer. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 52 - Sayı: 3, 194–196. https://ajindex.com/articles/363709

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Fukata M, Chen A, Vamadevan AS, Cohen J, Breglio K, Krishnareddy S, et al. Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 2007;133:1869–81.
  2. King AE, Critchley HO, Kelly RW. Presence of secretory leukocyte protease inhibitor in human endometrium and first trimester decidua suggests an antibacterial protective role. Mol Hum Reprod 2000;6:191–6.
  3. Fleming DC, King AE, Williams AR, Critchley HO, Kelly RW. Hormonal contraception can suppress natural antimicrobial gene transcription in human endometrium. Fertil Steril 2003;79:856–63.
  4. Sun J, Wiklund F, Zheng SL, Chang B, Bälter K, Li L, et al. Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk. J Natl Cancer Inst 2005;97:525–32.
  5. Schmausser B, Andrulis M, Endrich S, Müller-Hermelink HK, Eck M. Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells:an implication for interaction with Helicobacter pylori. Int J Med Microbiol 2005;295:179–85.
  6. Droemann D, Albrecht D, Gerdes J, Ulmer AJ, Branscheid D, Vollmer E, et al. Human lung cancer cells express functionally active Toll-like receptor 9. Respir Res 2005;6:1. Xie W, Wang Y, Huang Y, Yang H, Wang J, Hu Z. Toll-like receptor mediates invasion via activating NF-kappaB in MDAMB- 231 breast cancer cells. Biochem Biophys Res Commun 2009;379:1027–32.
  7. Kim WY, Lee JW, Choi JJ, Choi CH, Kim TJ, Kim BG, et al. Increased expression of Toll-like receptor 5 during progression of cervical neoplasia. Int J Gynecol Cancer 2008;18:300–5.
  8. Chen K, Huang J, Gong W, Iribarren P, Dunlop NM, Wang JM. Toll-like receptors in inflammation, infection and cancer. Int Immunopharmacol 2007;7:1271–85.
  9. Modugno F, Ness RB, Chen C, Weiss NS. Inflammation and endometrial cancer: a hypothesis. Cancer Epidemiol Biomarkers Prev 2005;14:2840–7.
  10. Young SL, Lyddon TD, Jorgenson RL, Misfeldt ML. Expression of Toll-like receptors in human endometrial epithelial cells and cell lines. Am J Reprod Immunol 2004;52:67–73.
  11. Schaefer TM, Desouza K, Fahey JV, Beagley KW, Wira CR. Toll- like receptor (TLR) expression and TLR-mediated cytokine/ chemokine production by human uterine epithelial cells. Immunology 2004;112:428–36.
  12. Zhou M, McFarland-Mancini MM, Funk HM, Husseinzadeh N, Mounajjed T, Drew AF. Toll-like receptor expression in normal ovary and ovarian tumors. Cancer Immunol Immunother 2009;58:1375–85.
  13. Ashton KA, Proietto A, Otton G, Symonds I, McEvoy M, Attia J, et al. Toll-like receptor (TLR) and nucle