Dergiler / Şişli Etfal Hastanesi Tıp Bülteni / 2018 / Cilt: 52 - Sayı: 2

Neonatal Diabetes Mellitus

Sayfa
71–78
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Close glucose monitoring and education of caregivers about diabetes are vital.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Neonatal diabetes is a rare cause of hyperglycemia in the neonatal period.
📊
Temel Bulgular & Veri:It is caused by mutations in genes that encode proteins playing critical roles in normal functions of pancreatic beta cells.
💡
Sonuç & Katkı:Close glucose monitoring and education of caregivers about diabetes are vital.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Neonatal diabetes is a rare cause of hyperglycemia in the neonatal period. It is caused by mutations in genes that encode proteins playing critical roles in normal functions of pancreatic beta cells. Neonatal diabetes is divided into temporary and permanent subtypes. Treatment is based on the correction of fluid-electrolyte disturbances and hyperglycemia. Patients respond to insulin or sulfonylurea treatment according to the mutation type. Close glucose monitoring and education of caregivers about diabetes are vital.

🔖

Bu Makaleye Atıf Yap

ZÜBARİOĞLU, A. U., BÜLBÜL, A., USLU, H. S. (2018). Neonatal Diabetes Mellitus. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 52 - Sayı: 2, 71–78. https://ajindex.com/articles/363692

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (9)

  1. Babenko AP, Polak M, Cavé H, Busiah K, Czernichow P, Scharfmann R, et al. Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. N Engl J Med 2006;355:456–66.
  2. S Pearson ER, Flechtner I, Njølstad PR, Malecki MT, Flanagan SE, Larkin B, et al; Neonatal Diabetes International Collaborative Group. Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med 2006;355:467–77.
  3. Clark RH, McTaggart JS, Webster R, Mannikko R, Iberl M, Sim XL, et al. Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin. Science 2010;329:458–61. 27. Hattersley AT, Ashcroft FM. Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy. Diabetes 2005;54:2503–13. lingerland AS, Hattersley AT. Activating mutations in the gene encoding Kir6.2 alter fetal and postnatal growth and also cause neonatal diabetes. J Clin Endocrinol Metab 2006;91:2782–88.
  4. Vaxillaire M, Populaire C, Busiah K, Cavé H, Gloyn AL, Hattersley AT, et al. Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients. Diabetes 2004;53:2719–22.
  5. Gloyn AL, Cummings EA, Edghill EL, Harries LW, Scott R, Costa T, et al. Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 Gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel. J Clin Endocrinol Metab 2004;89:3932–5.
  6. Gloyn AL, Pearson ER, Antcliff JF, Proks P, Bruining GJ, Slingerland AS, et al. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med 2004;350:1838–49.
  7. Rubio-Cabezas O, Klupa T, Malecki MT; CEED3 Consortium. Permanent neonatal diabetes mellitus–the importance of diabetes differential diagnosis in neonates and infants. Eur J Clin Invest 2010;41:323–33.
  8. Shield JP, Temple IK, Sabin M, Mackay D, Robinson DO, Betts PR, et al. An assessment of pancreatic endocrine function and insulin sensitivity in patients with transient neonatal diabetes in remission. Arch Dis Child Fetal Neonatal Ed 2004;89:341–3. 18. Docherty LE, Kabwama S, Lehmann A, Hawke E, Harrison L, Flanagan SE, et al. Clinical presentation of 6q24 transient neonatal diabetes mellitus (6q24 TNDM) and genotype-phenotype correlation in an international cohort of patients. Diabetologia 2013;56:758–62.
  9. Temple IK, Gardner RJ, Mackay DJ, Barber