İdiyopatik trombositopenik purpura (ITP) tedavisinde platelet sayısını arttırmak için steroidler, immunsupresif ajanlar ve splenektomi kullanılmaktadır. Reaktif trombositoz infeksiyon, travma, malignansi gibi çeşitli durumlarda platelet sayısının normalin üzerine çıkmasıdır. Literatürde ITP hastalarında reaktif trombositozun görülebildiğine dair az sayıda yayın bulunmaktadır.
Abstract
In treatment of idiopathic thrombocytopenic purpura (ITP) steroids, immunosuppresive agents and splenectomy is used to increase the platelet count. Reactive thrombocytosis is defined as an increase in platelet count above normal secondary to the presence of various conditions such as infection, trauma and malignancy. In the literature occurence reactive thrombocytosis in the setting of ITP has rarely been reported.
KÜÇÜKLER, F. K., ERSOY, Ç. Y., OKUTUR, S. K., BES, C., ŞİRİN, G., KERİMOĞLU, Ü., ÖZTÜRK, S., DALAR, L., BORLU, F. (2004). İdiyopatik trombositopenik purpura tanısı olan bir hastada infeksiyona sekonder gelişen reaktif trombositoz. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 38 - Sayı: 2, 48–52. https://ajindex.com/articles/363604
Kaynakça (2)
Geoege JN, Woolf Sil, Raskob GE, et al. Idiopatik thrombocytopenic purpura: A practice guideline developed by explicit methods for the American Society of Hematology. Blood, 88:3, 1996 2. Kuter D.I. Reactive thrombocytosis. Williams Hematology Textbook, 1348, 2001 3. Frederiksen H, Schmidt K. The incidence of ITP in adults increases with age. Blood, 94:909, I 999 4. Harrington WJ. Minnich V. Hollingsworth JW, Moore CV. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. j Lab Clin Med, 38:1, 1951 5. Altman LK. Black and blue at the flick of a feather, in Anonymous. Who Goes First?, p:273-282.
New York, Random House, 1987 6. He R, Reid DM, Jones CE, Shulman NR. Spectrum or Ig classes, specilitfcs and liters ol serum antiglycoprotcins in chronic idiopathic thrombocytopenie purpura. Blood, 83:1024, 1994 7. Berchtold P, Wengcr M. Autoantibodies against platelet glycoproteins in autoimmune thrombocylopcnic purpura:their clinical significance and response to treatment. Blood, 81:1246. 1993 8. Woerner SJ. Abildgaard CF. French BN. Intracranial hemorrhage in children with idiopathic thrombocytopenic purpura. Pedatrics. 67:453. 1981 9. Lee MS, Kim WC. Intracranial hemorrhage associated with idiopathic thrombocytopenie purpura: Report of seven patients and a meta-analysis. Neurology, 50:1160, 1998 10. Mayan H, Salomon O. Pauzner R. Farfel Z. EDTA-induced pseudotlmmibocytopenia. South Med J. 85:213, 1992 11. Najean Y, Lecompte T. Chronic pure thrombocytopenia in elderly patients: An aspect of the myelodisplastic syndrome. Cancer. 64:2506. 1989 12. Imbach P, d'Apuzzo V, Hirt A, et al. High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet, 1:1228, 1981 13. Kaltainis AC, Shankar S, Cohen AR. Neurologic complication of treatment of childhood acute immune thrombocylopcnic purpura with intravenously administered immunoglobulin. G. J Pediatr, 130:281, 1997 14. Buss DH, Cashell AW, O'Connor ML, Richards F. Occurence, etiology and clinical significance of extreme thrombocytosis:a study of 280 cases. Am J Med, 247:53, 1994 15. Blay J, Favrot M, Rossi j, Wijdenes J. Role of interleukin-6 in paraneoplaslic thrombocytosis. Blood, 1993: 82:2261-2262. 16. Weber J, Yang JC, Topalian SL, et al. Phase 1 trial of subcutaneous interleukin-6 in patients with advanced malignancies. J Clin Oncol, 1993; 11:499-506. 17. Costello C. Virus infection-associated improvement of platelet counts in chronic