Dergiler / Şişli Etfal Hastanesi Tıp Bülteni / 2020 / Cilt: 54 - Sayı: 3

Evaluation of Magnetic Resonance (MR) Findings in Patients with Refractory Epilepsy

Sayfa
371–374
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

We think that clinicians can guide the planningof treatment of the MR findings.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objectives: Epilepsy is characterized as a tendency towards recurrent seizures and it is a significant health problem in the worldand one of the most common severe neurologic disorders among children.
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Temel Bulgular & Veri:This study aims to evaluate the outcome of magneticresonance imaging in determining the etiology in patients with refractory epilepsy and to reveal pathologies that may have thepotential to be treated with methods, such as epileptic surgery.Methods: Data were obtained from the patient files of the patients diagnosed with epilepsy and monitored for at least two yearsbetween 01.01.2009-12.31.2012 in the Uludag Faculty of Medicine, the Division of the Pediatric Neurology.
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Sonuç & Katkı:We think that clinicians can guide the planningof treatment of the MR findings.
🔬Tür:Araştırma Makalesi
📍Kapsam:2009 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Objectives: Epilepsy is characterized as a tendency towards recurrent seizures and it is a significant health problem in the worldand one of the most common severe neurologic disorders among children. This study aims to evaluate the outcome of magneticresonance imaging in determining the etiology in patients with refractory epilepsy and to reveal pathologies that may have thepotential to be treated with methods, such as epileptic surgery.Methods: Data were obtained from the patient files of the patients diagnosed with epilepsy and monitored for at least two yearsbetween 01.01.2009-12.31.2012 in the Uludag Faculty of Medicine, the Division of the Pediatric Neurology. File records of the patients,age, sex and MRI findings of the patients were recorded.Results: One hundred twenty were girls (49%) and 125 were male (51%) of the cases. The age range ranged from 1 to 18 years andthe median value was 8.3 (1-18) years. One hundred twenty of the 245 patients who met the diagnostic criteria for resistant epilepsywas found as well controlled. In patients with resistant epilepsy, the findings of these two groups of patients were comparedconcerning MR findings. Among all patients, 154 (62.8%) patients were found to have MR pathology. Of these patients, 83 (53.9%)were in the resistant group and 71 (46.1%) were in the well-controlled group. There was no significant difference in the presence ofMR findings between the two groups (p=0.354). The highest incidence (24.8%) of the encephalomalacia in patients in the resistantgroup may explain the association of perinatal hypoxia with resistance development.Conclusion: If patients with epilepsy can be predicted early in the disease, which group of the patients will not respond wellto medical treatment; unlike other patients, different treatment modalities, such as antiepileptic use, vagal nerve stimulation,ketogenic diet and epilepsy surgery, can be applied to this group of the patients. We think that clinicians can guide the planningof treatment of the MR findings.

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Bu Makaleye Atıf Yap

ÇAT, F. Ç., OKAN, M. S. (2020). Evaluation of Magnetic Resonance (MR) Findings in Patients with Refractory Epilepsy. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 54 - Sayı: 3, 371–374. https://ajindex.com/articles/363387

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Kaynakça (20)

  1. Banerjee PN, Filippi D, Allen Hauser W. The descriptive epidemiology of epilepsy-a review. Epilepsy Res 2009;85:31–45
  2. Berg AT. Defining intractable epilepsy. Adv Neurol 2006;97:5–10
  3. Berg AT, Kelly MM. Defining intractability: comparisons among published definitions. Epilepsia 2006;47:431–6
  4. French JA. Refractory epilepsy: one size does not fit all. Epilepsy Curr 2006;6:177–80
  5. Berg AT, Shinnar S, Levy SR, Testa FM, Smith-Rapaport S, Beckerman B. Early development of intractable epilepsy in children: a prospective study. Neurology 2001;56:1445–52
  6. Berg AT, Levy SR, Novotny EJ, Shinnar S. Predictors of intractable epilepsy in childhood: a case-control study. Epilepsia 1996;37:24– 30
  7. Aneja S, Jain P. Refractory epilepsy in children. Indian J Pediatr 2014;81:1063–72
  8. Eriksson KJ, Koivikko MJ. Prevalence, classification, and severity of epilepsy and epileptic syndromes in children. Epilepsia 1997;38:1275–82
  9. Brodie MJ, Leach JP. Success or failure with antiepileptic drug therapy: Beyond empiricism?. Neurology 2003;60:162–3
  10. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342:314–9
  11. Harrison RM, Taylor DC. Childhood seizures: a 25-year follow up. Social and medical prognosis. Lancet 1976;1:948–51
  12. Reynolds EH, Elwes RD, Shorvon SD. Why does epilepsy become intractable? Prevention of chronic epilepsy. Lancet 1983;2:952–4
  13. Mattson RA. Selection of drugs for treatment of epilepsy. Semin Neurol 1990;10: 406–13
  14. National Institutes of Health Consensus Development Conference Statement: Surgery for Epilepsy, March 19-21, 1990. Epilepsia 1990;31:806–12
  15. Chawla S, Aneja S, Kashyap R, Mallika V. Etiology and clinical predictors of intractable epilepsy. Pediatr Neurol 2002;27:186–91
  16. Ko TS, Holmes GL. EEG and clinical predictors of medically intractable childhood epilepsy. Clin Neurophysiol 1999;110:1245–51
  17. Gururaj A, Sztriha L, Hertecant J, Eapen V. Clinical predictors of intractable childhood epilepsy. J Psychosom Res 2006;61:343–7
  18. Hutter D, Kingdom J, Jaeggi E. Causes and mechanisms of intrauterine hypoxia and its impact on the fetal cardiovascular system: a review. Int J Pediatr 2010;2010:401323
  19. Golubnitschaja O, Yeghiazaryan K, Cebioglu M, Morelli M, Herrera- Marschitz M. Birth asphyxia as the major complication in newborns: moving towards improved individual outcomes by prediction, targeted prevention and tailored medical care. EPMA J 2011;2:197–210
  20. Ferrier