Dergiler / Ağrı / 2021 / Cilt: 33 - Sayı: 3

The effect of circadian rhytm in patients undergoing spinal anesthesia

Spinal anestezi uygulanan hastalarda sirkadiyen ritmin etkisi

Dergi
Ağrı
Sayfa
168–175
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

There were no statistically significant differences between thegroups in terms of side effects and the most common side effect was detected to be nausea-vomiting.Conclusion: We found out that the time to first analgesic request after spinal anesthesia was significantly longer in Group 1than in Group 2.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objectives: The circadian rhythm is the most important of the main rhythms that affect our daily lives and has a significantrole in the efficiency of a lot of drugs used in anesthesia.
📊
Temel Bulgular & Veri:The aim of this study is to prove whether circadian rhythm has aneffect on spinal anesthesia and, if any, its effect on post-operative analgesic request by retrospectively studying the patientsoperated under spinal anesthesia.Methods: We conducted the study on patients operated on inguinal hernia and anorectal surgery under spinal anesthesia ingeneral surgery room.
💡
Sonuç & Katkı:There were no statistically significant differences between thegroups in terms of side effects and the most common side effect was detected to be nausea-vomiting.Conclusion: We found out that the time to first analgesic request after spinal anesthesia was significantly longer in Group 1than in Group 2.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objectives: The circadian rhythm is the most important of the main rhythms that affect our daily lives and has a significantrole in the efficiency of a lot of drugs used in anesthesia. The aim of this study is to prove whether circadian rhythm has aneffect on spinal anesthesia and, if any, its effect on post-operative analgesic request by retrospectively studying the patientsoperated under spinal anesthesia.Methods: We conducted the study on patients operated on inguinal hernia and anorectal surgery under spinal anesthesia ingeneral surgery room. The patients were divided into two groups according to the time when they were taken into surgery:Between 06.00–12.00 (Group 1) and 12.00–18.00 (Group 2). Time to first analgesic request, time to start walking, time to firsturination, intraoperative and post-operative side effects, intraoperative hemodynamic data, and patient satisfaction were detectedand recorded.Results: The time to first analgesic request in Group 1 was longer than in Group 2, and this difference was statistically significant.The mean heart rate of the groups was found significantly lower in Group 2 than in Group 1 during measurements at the25 and 30 min when compared with their changes overtime. There were no statistically significant differences between thegroups in terms of side effects and the most common side effect was detected to be nausea-vomiting.Conclusion: We found out that the time to first analgesic request after spinal anesthesia was significantly longer in Group 1than in Group 2.

Abstract

Amaç: Sirkadiyen ritim günlük yaşamımızda etkisi altında kaldığımız başlıca ritimlerden en önemlisidir ve anestezide kullandığımız birçok ilacın etkinliğinde önemli rol oynamaktadır Bu çalışmanın amacı spinal anestezi altında opere olan hastaları retrospektif olarak inceleyerek sirkadiyen ritmin spinal anestezi uygulanan hastalarda postoperatif analjezi gereksinimi üzerine olan etkisini ortaya koymaktır. Gereç ve Yöntem: Çalışmamız spinal anestezi altında genel cerrahi ameliyathanesinde ingüinal herni ve anorektal cerrahi operasyonu geçiren hastalarda gerçekleştirildi. Hastalar cerrahiye alındıkları saate göre iki gruba ayrıldı: Saat 06.00–12.00 (Grup 1) ve 12.00–18.00 (Grup 2). Postoperatif ilk analjezik gereksinim süreleri, ilk yürüme zamanları, ilk idrar yapma zamanları, intraoperatif hemodinamik veriler, intraoperatif ve postoperatif yan etkiler ve hasta memnuniyetleri belirlenerek kaydedildi. Bulgular: Postoperatif ilk analjezik ihtiyacı zamanı Grup 1’de Grup 2’ye göre daha uzun saptanmış olup, bu fark istatistiksel olarak anlamlı bulundu. Gruplara ait kalp atım hızı ortalamaları, zaman içerisindeki değişimleri açısından karşılaştırıldığında 25. ve 30. dakika ölçümlerinde Grup 2’de Grup 1’e göre anlamlı olarak düşük bulundu. Yan etkilere bakıldığında gruplar arası istatistiksel olarak anlamlı bir fark olmadığı, iki grupta da en sık görülen yan etkinin bulantı-kusma olduğu tespit edildi. Sonuç: Spinal anestezi sonrası ilk analjezi gereksinim zamanının Grup 1’de Grup 2’ye göre anlamlı derecede uzun olduğunu saptadık.

🔖

Bu Makaleye Atıf Yap

KILIÇARSLAN, G., ALKAN, M., KURTİPEK, Ö., ÜNAL, Y., ŞIVGIN, V., DİKMEN, K., TURHAN, S., ARSLAN, M. (2021). The effect of circadian rhytm in patients undergoing spinal anesthesia. Ağrı, Cilt: 33 - Sayı: 3, 168–175. https://ajindex.com/articles/353294

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (16)

  1. Lee HS, Billings HJ, Lehman MN. The suprachiasmatic nucleus: A clock of multiple components. J Biol Rhythms 2003
  2. 18(6):435–49. [CrossRef ] 2. Zee PC, Manthena P. The brain’s master circadian clock: İmplications and opportunities for therapy of sleep disorders. Sleep Med Rev 2007
  3. 11(1):59–70. [CrossRef ] 3. Okamura H. Integration of mammalian circadian clock signals: From molecule to behavior. J Endocrinol 2003
  4. 177(1):3–6. [CrossRef ] 4. Gery S, Komatsu N, Baldjyan L, Yu A, Koo D, Koeffler HP. The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol Cell 2006
  5. 22(3):375–82. [CrossRef ] 5. Arendt J. Melatonin and human rhythms. Chronob Int 2006
  6. 23(1–2):21–37. [CrossRef ] 6. Reinberg A, Reinberg MA. Circadian changes of the duration of action of local anaesthetic agents. Naunyn Schmiedebergs Arch Pharmacol 1977
  7. 297(2):149–52. [CrossRef ] 7. Challet E, Gourmelen S, Pevet P, Oberling P, Pain L. Reciprocal relationships between general (propofol) anesthesia and circadian time in rats. Neuropsychopharmacology 2007
  8. 32(3):728–35. [CrossRef ] 8. Debon R, Chassard D, Duflo F, Boselli E, Bryssine B, Allaouchiche B. Chronobiology of epidural ropivacaine variations in the duration of action related to the hour of administration. Anesthesiology 2002
  9. 96(3):542–45. [CrossRef ] 9. Simmons D. Lesker PA, Sherman N. Induction of sodium pentobarbital anesthesia. A circadian rhythm. J Interdiscip Cycle Res 1974
  10. 5(1):71–5.[CrossRef ] 10. Koopmans R, Dingemanse J, Danhof M, Horsten GP, Boxtel CJ. The influence of dosage time of midazolam on its pharmacokinetics and effects in humans. Clin Pharmacol Ther 1991
  11. 50(1):16–24. [CrossRef ] 11. Munson ES, Martucci RW, Smith RE. Circadian variations in anesthetic requirement and toxicity in rats. Anesthesiology 1970
  12. 32(6):507–14. [CrossRef ] 12. Kerdelhue, B, Palkovits M, Karteszi M, Reinberg A. Circadian parathion in substance P, luliberin (LH-RH) and thyroliberin (TRH) contents in hypothalamic and extrahypothalamic brain nuclei of adult male rats. Brain Res 1981
  13. 405–13. 13. Aya AG, Vialles N, Mangin R, Robert C, Ferrer JM, Ripart J, et al. Chronobiology of labour pain perception: an observational study. Br J Anaesth 2004
  14. 93(3):451–3. [CrossRef ] 14. Morris RW, Lutsch EF. Susceptibility to morphine-induced analgesia in mice. Nature 1967
  15. 216(5114):494–5. [CrossRef ] 15. Liu X, Song J. Chronopharmacology of tramadol in mice. Yao Xue Xue Bao 2001
  16. 36(8):561–4. 16. Auvil-Novak SE, N