There are differences in the autoantibodies distribution ofSLE patients with different organ damage, suggesting a certain clinical value for prediction of organ damage in SLE.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:Objectives: This study aims to investigate the positive detection rate and predictive value of autoantibodies, including anti-double strandeddeoxyribonucleic acid (anti-dsDNA) antibodies, anti-histone antibodies (AHAs), anti-ribosomal (anti-Rib) P antibodies, anti-Smith (anti-Sm)antibodies, anti-U1 ribonucleoprotein (anti-U1RNP) antibodies, anti-Sjögren’s syndrome type A antibodies and anti-Sjögren’s syndrome type Bantibodies, on organ damage in patients with systemic lupus erythematous (SLE).Patients and methods: A total of 225 patients with SLE (37 males, 188 females; mean age 37.4±15.9 years; range, 7 to 80 years) were evaluatedretrospectively.
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Temel Bulgular & Veri:Statistical analysis was performed to obtain the positive detection rate of autoantibodies and to investigate the predictive value.Results: There were statistically significant differences of positive anti-dsDNA antibodies in renal damage, photosensitization, hematologicalabnormalities and serositis (p 0.05).Conclusion: Autoantibody spectrum is an important serological basis for SLE diagnosis.
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Sonuç & Katkı:There are differences in the autoantibodies distribution ofSLE patients with different organ damage, suggesting a certain clinical value for prediction of organ damage in SLE.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Özet
Objectives: This study aims to investigate the positive detection rate and predictive value of autoantibodies, including anti-double strandeddeoxyribonucleic acid (anti-dsDNA) antibodies, anti-histone antibodies (AHAs), anti-ribosomal (anti-Rib) P antibodies, anti-Smith (anti-Sm)antibodies, anti-U1 ribonucleoprotein (anti-U1RNP) antibodies, anti-Sjögren’s syndrome type A antibodies and anti-Sjögren’s syndrome type Bantibodies, on organ damage in patients with systemic lupus erythematous (SLE).Patients and methods: A total of 225 patients with SLE (37 males, 188 females; mean age 37.4±15.9 years; range, 7 to 80 years) were evaluatedretrospectively. Statistical analysis was performed to obtain the positive detection rate of autoantibodies and to investigate the predictive value.Results: There were statistically significant differences of positive anti-dsDNA antibodies in renal damage, photosensitization, hematologicalabnormalities and serositis (p 0.05).Conclusion: Autoantibody spectrum is an important serological basis for SLE diagnosis. There are differences in the autoantibodies distribution ofSLE patients with different organ damage, suggesting a certain clinical value for prediction of organ damage in SLE.
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Bu Makaleye Atıf Yap
YUAN, F., WEI, F., HUANG, H., XUE, Y., GUO, P., YOU, Y. (2019). The Predictive Value of Autoantibody Spectrum on Organ Damage in Patients With Systemic Lupus Erythematosus. art, Cilt: 34 - Sayı: 2, 157–165. https://ajindex.com/articles/351668
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